SUT13_ARATH
ID SUT13_ARATH Reviewed; 656 AA.
AC Q9FEP7; Q9LM44;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=Sulfate transporter 1.3;
GN Name=SULTR1;3; OrderedLocusNames=At1g22150; ORFNames=F2E2.22;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION, AND
RP NULL MUTANT.
RC STRAIN=cv. Columbia;
RX PubMed=12692311; DOI=10.1104/pp.014712;
RA Yoshimoto N., Inoue E., Saito K., Yamaya T., Takahashi H.;
RT "Phloem-localizing sulfate transporter, sultr1;3, mediates re-distribution
RT of sulfur from source to sink organs in Arabidopsis.";
RL Plant Physiol. 131:1511-1517(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: High-affinity H(+)/sulfate cotransporter that mediates the
CC loading of sulfate into the sieve tube. Plays a central role in the
CC regulation of sulfate assimilation. {ECO:0000269|PubMed:12692311}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the phloem of cotyledons, hypocotyls
CC and roots. {ECO:0000269|PubMed:12692311}.
CC -!- INDUCTION: In roots and leaves by sulfate starvation.
CC {ECO:0000269|PubMed:12692311}.
CC -!- MISCELLANEOUS: Loss-of-function mutation of the gene result in an
CC attenuation of the source-to-sink transport of sulfate.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF86552.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB049624; BAB16410.1; -; mRNA.
DR EMBL; AC069252; AAF86552.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30203.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM58633.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM58634.1; -; Genomic_DNA.
DR PIR; B86354; B86354.
DR RefSeq; NP_001319061.1; NM_001332538.1.
DR RefSeq; NP_001321055.1; NM_001332540.1.
DR RefSeq; NP_564159.1; NM_102065.2.
DR AlphaFoldDB; Q9FEP7; -.
DR SMR; Q9FEP7; -.
DR BioGRID; 24059; 19.
DR IntAct; Q9FEP7; 17.
DR STRING; 3702.AT1G22150.1; -.
DR iPTMnet; Q9FEP7; -.
DR PaxDb; Q9FEP7; -.
DR PRIDE; Q9FEP7; -.
DR ProteomicsDB; 226754; -.
DR EnsemblPlants; AT1G22150.1; AT1G22150.1; AT1G22150.
DR EnsemblPlants; AT1G22150.3; AT1G22150.3; AT1G22150.
DR EnsemblPlants; AT1G22150.4; AT1G22150.4; AT1G22150.
DR GeneID; 838820; -.
DR Gramene; AT1G22150.1; AT1G22150.1; AT1G22150.
DR Gramene; AT1G22150.3; AT1G22150.3; AT1G22150.
DR Gramene; AT1G22150.4; AT1G22150.4; AT1G22150.
DR KEGG; ath:AT1G22150; -.
DR Araport; AT1G22150; -.
DR TAIR; locus:2030606; AT1G22150.
DR eggNOG; KOG0236; Eukaryota.
DR HOGENOM; CLU_003182_13_2_1; -.
DR InParanoid; Q9FEP7; -.
DR OMA; CKDCTIG; -.
DR OrthoDB; 690428at2759; -.
DR PhylomeDB; Q9FEP7; -.
DR PRO; PR:Q9FEP7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FEP7; baseline and differential.
DR Genevisible; Q9FEP7; AT.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR030314; High_sul_transp.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR PANTHER; PTHR11814:SF207; PTHR11814:SF207; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR TIGRFAMs; TIGR00815; sulP; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Sulfate transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..656
FT /note="Sulfate transporter 1.3"
FT /id="PRO_0000080174"
FT TOPO_DOM 1..94
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..119
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..176
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..256
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..283
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..342
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 364..375
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 397..412
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 434..441
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 463..473
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 474..494
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 495..656
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 525..648
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 656 AA; 72227 MW; 462D022C91082A89 CRC64;
MSARAHPVDD DGEISPVERS SPRQANTPYV HKVEVPPKQN LFNEFMYTFK ETFFHDDPLR
HFKDQSKSKK LMLGIQSVFP VIEWGRKYNL KLFRGDLIAG LTIASLCIPQ DIGYAKLASL
DPKYGLYSSF VPPLVYACMG SSKDIAIGPV AVVSLLLGTL LRAEIDPNTN PNEYLRLAFT
STFFAGVTQA ALGFFRLGFL IDFLSHAAVV GFMGGAAITI ALQQLKGFLG INKFTKKTDI
IAVLSSVISS AHHGWNWQTI LISASFLIFL LISKFIGKRN KKLFWIPAIA PLVSVIISTF
FVYITRADKK GVQIVKHLDK GLNPSSLRLI YFSGDYLLKG FRIGVVSGMV ALTEAVAIGR
TFAAMKDYQI DGNKEMVALG AMNVIGSMTS CYVSTGSFSR SAVNFMAGCQ TAVSNIIMSI
VVLLTLLFLT PLFKYTPNAI LAAIIINAVI PLVDVNATIL IFKIDKLDFV ACMGAFFGVI
FVSVEIGLLI AVGISFAKIL LQVTRPRTAI LGKIPGTSVY RNINQYPEAT RIPGVLTIRV
DSAIYFSNSN YVRERIQRWL TDEEEMVEAA RLPRIQFLII EMSPVTDIDT SGIHALEDLY
KSLQKRDIQL VLANPGPPVI NKLHVSHFAD LIGHDKIFLT VAEAVDSCSP KLSDEV
