ID   SUT2_YEAST              Reviewed;         268 AA.
AC   Q12286; D6W420;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Sterol uptake protein 2;
GN   Name=SUT2; OrderedLocusNames=YPR009W; ORFNames=LPZ9w;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169875;
RA   Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA   Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA   Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA   Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA   DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA   Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA   Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA   Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA   Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA   Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA   Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA   Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA   Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA   Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA   Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA   Vo D.H., Hani J.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL   Nature 387:103-105(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   FUNCTION.
RX   PubMed=11248676; DOI=10.1046/j.1432-1033.2001.02029.x;
RA   Ness F., Bourot S., Regnacq M., Spagnoli R., Berges T., Karst F.;
RT   "SUT1 is a putative Zn[II]2Cys6-transcription factor whose upregulation
RT   enhances both sterol uptake and synthesis in aerobically growing
RT   Saccharomyces cerevisiae cells.";
RL   Eur. J. Biochem. 268:1585-1595(2001).
RN   [4]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=15030478; DOI=10.1111/j.1432-1033.2004.04034.x;
RA   Ruetzler M., Reissaus A., Budzowska M., Bandlow W.;
RT   "SUT2 is a novel multicopy suppressor of low activity of the cAMP/protein
RT   kinase A pathway in yeast.";
RL   Eur. J. Biochem. 271:1284-1291(2004).
CC   -!- FUNCTION: Putative transcription factor involved in the regulation of
CC       the activity of the cAMP/protein kinase A pathway. Involved in sterol
CC       uptake. {ECO:0000269|PubMed:11248676, ECO:0000269|PubMed:15030478}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15030478}.
CC   -!- SIMILARITY: Belongs to the SUT1 family. {ECO:0000305}.
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DR   EMBL; U31900; AAA97588.1; -; Genomic_DNA.
DR   EMBL; Z49919; CAA90153.1; -; Genomic_DNA.
DR   EMBL; Z71255; CAA95049.1; -; Genomic_DNA.
DR   EMBL; BK006949; DAA11436.1; -; Genomic_DNA.
DR   PIR; S57542; S57542.
DR   RefSeq; NP_015334.1; NM_001184106.1.
DR   AlphaFoldDB; Q12286; -.
DR   BioGRID; 36187; 100.
DR   iPTMnet; Q12286; -.
DR   PaxDb; Q12286; -.
DR   PRIDE; Q12286; -.
DR   EnsemblFungi; YPR009W_mRNA; YPR009W; YPR009W.
DR   GeneID; 856118; -.
DR   KEGG; sce:YPR009W; -.
DR   SGD; S000006213; SUT2.
DR   VEuPathDB; FungiDB:YPR009W; -.
DR   eggNOG; ENOG502S235; Eukaryota.
DR   GeneTree; ENSGT00940000176592; -.
DR   HOGENOM; CLU_051216_0_0_1; -.
DR   InParanoid; Q12286; -.
DR   OMA; XKINSKL; -.
DR   BioCyc; YEAST:G3O-34171-MON; -.
DR   PRO; PR:Q12286; -.
DR   Proteomes; UP000002311; Chromosome XVI.
DR   RNAct; Q12286; protein.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; HDA:SGD.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:SGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:SGD.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..268
FT                   /note="Sterol uptake protein 2"
FT                   /id="PRO_0000115015"
SQ   SEQUENCE   268 AA;  30258 MW;  69B89766F75FDBAE CRC64;
     MKPNNRTCDV ITNKDESLPA LLLPALNSYT CDDSLLKGQI SSNGRYQPFG FSDCSLLPKR
     LNIQAGQGSM PVSSIQCADH SYSNWQKESE KTKLPKLGCP TEYTEYYKTV SSGETTDSAV
     VSSIATNRLK RKRQRDGPSC DSCRIKKIKC NATIIIFLQD RNLISSISSN LHYTLSQDDI
     NQFRMKFFRK LPDVMGTYEV IKHLDKIVLF KACTSCSRRN QKNGKCLFSR GFTKSDMNVF
     PKINSKLKDK SIFEMTVDDY VAAGFQTL