SUT42_ARATH
ID SUT42_ARATH Reviewed; 677 AA.
AC Q8GYH8; Q9LHF7;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 26-SEP-2003, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Probable sulfate transporter 4.2;
GN Name=SULTR4;2; OrderedLocusNames=At3g12520; ORFNames=MQC3.34, T2E22.36;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Takahashi H., Watanabe-Takahashi A., Saito K., Yamaya T.;
RT "cDNA for sulfate transporter Sultr4;2.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
CC -!- FUNCTION: H(+)/sulfate cotransporter that may play a role in the
CC regulation of sulfate assimilation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8GYH8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8GYH8-2; Sequence=VSP_041589;
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000305}.
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DR EMBL; AB052775; BAB19761.1; -; mRNA.
DR EMBL; AP002047; BAB03159.1; -; Genomic_DNA.
DR EMBL; AC069474; AAG51021.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75205.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75206.1; -; Genomic_DNA.
DR EMBL; AK117615; BAC42271.1; -; mRNA.
DR RefSeq; NP_001189871.1; NM_001202942.1. [Q8GYH8-2]
DR RefSeq; NP_187858.1; NM_112087.3. [Q8GYH8-1]
DR AlphaFoldDB; Q8GYH8; -.
DR SMR; Q8GYH8; -.
DR STRING; 3702.AT3G12520.1; -.
DR PaxDb; Q8GYH8; -.
DR PRIDE; Q8GYH8; -.
DR ProteomicsDB; 226833; -. [Q8GYH8-1]
DR EnsemblPlants; AT3G12520.1; AT3G12520.1; AT3G12520. [Q8GYH8-1]
DR EnsemblPlants; AT3G12520.2; AT3G12520.2; AT3G12520. [Q8GYH8-2]
DR GeneID; 820431; -.
DR Gramene; AT3G12520.1; AT3G12520.1; AT3G12520. [Q8GYH8-1]
DR Gramene; AT3G12520.2; AT3G12520.2; AT3G12520. [Q8GYH8-2]
DR KEGG; ath:AT3G12520; -.
DR Araport; AT3G12520; -.
DR TAIR; locus:2092517; AT3G12520.
DR eggNOG; KOG0236; Eukaryota.
DR InParanoid; Q8GYH8; -.
DR OMA; SKHNALG; -.
DR OrthoDB; 690428at2759; -.
DR PhylomeDB; Q8GYH8; -.
DR PRO; PR:Q8GYH8; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8GYH8; baseline and differential.
DR Genevisible; Q8GYH8; AT.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR TIGRFAMs; TIGR00815; sulP; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Sulfate transport;
KW Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..677
FT /note="Probable sulfate transporter 4.2"
FT /id="PRO_0000080182"
FT TOPO_DOM 1..83
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..108
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..161
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..189
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..241
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..269
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..318
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 340..355
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 377..392
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 414..420
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 442..459
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 481..677
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 505..629
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT VAR_SEQ 7..22
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11910074"
FT /id="VSP_041589"
SQ SEQUENCE 677 AA; 74662 MW; 11C87626A781DB71 CRC64;
MSLAVKDLST ASSSSSKAIP VKIIPLQYPD STSSDPHCHS IPFNDFFSRW TAKIKRMTFF
DWIDAIFPCF LWIRTYRWHQ YFKLDLMAGI TVGIMLVPQA MSYARLAGLQ PIYGLYSSFV
PVFVYAVFGS SRQLAVGPVA LVSLLVSNAL SGIVDPSEEL YTELAILLAL MVGIFESIMG
FLRLGWLIRF ISHSVISGFT TASAVVIGLS QLKYFLGYSV SRSSKIMPVI DSIIAGADQF
KWPPFLLGCT ILVILLVMKH VGKAKKELRF IRAAGPLTGL ALGTIIAKVF HPPSITLVGD
IPQGLPKFSF PKSFDHAKLL LPTSALITGV AILESVGIAK ALAAKNRYEL DSNSELFGLG
VANIFGSLFS AYPTTGSFSR SAVNSESEAK TGLSGLVTGI IIGCSLLFLT PMFKFIPQCA
LAAIVISAVS GLVDYEGAIF LWRVDKRDFT LWTITSTTTL FFGIEIGVLI GVGFSLAFVI
HESANPHIAV LGRLPGTTVY RNMKQYPEAY TYNGIVIVRI DAPIYFANIS YIKDRLREYE
VAIDKHTSKG PDMERIYFVI LEMSPVTYID SSAVEALKDL YEEYKTRGIQ LAISNPNKEV
LLTLARAGIV ELIGKEWFFV RVHDAVQVCV HYVNRPTDVE ESSKPSLWRR SGLKNSSTYT
EVESNIVLEE PLLSREK
