SUTA_PSEAB
ID SUTA_PSEAB Reviewed; 105 AA.
AC A0A0H2ZJC1;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 16-SEP-2015, sequence version 1.
DT 03-AUG-2022, entry version 18.
DE RecName: Full=Transcriptional regulator SutA {ECO:0000305};
DE AltName: Full=Survival under transitions A {ECO:0000303|PubMed:26787849};
GN Name=sutA {ECO:0000303|PubMed:26787849};
GN OrderedLocusNames=PA14_69770 {ECO:0000312|EMBL:ABJ14670.1};
OS Pseudomonas aeruginosa (strain UCBPP-PA14).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCBPP-PA14;
RX PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G.,
RA Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT combinatorial.";
RL Genome Biol. 7:R90.1-R90.14(2006).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH RNAP,
RP INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=UCBPP-PA14;
RX PubMed=26787849; DOI=10.1073/pnas.1514412113;
RA Babin B.M., Bergkessel M., Sweredoski M.J., Moradian A., Hess S.,
RA Newman D.K., Tirrell D.A.;
RT "SutA is a bacterial transcription factor expressed during slow growth in
RT Pseudomonas aeruginosa.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:E597-E605(2016).
CC -!- FUNCTION: Causes widespread changes in gene expression, and plays a
CC direct role in the regulation of genes encoding ribosomal components.
CC Associates with chromosomal DNA through interaction with RNA
CC polymerase. Contributes to biofilm formation and secondary metabolite
CC production. Important during transitions to and from the survival
CC state. {ECO:0000269|PubMed:26787849}.
CC -!- SUBUNIT: Interacts with RNA polymerase. {ECO:0000269|PubMed:26787849}.
CC -!- INDUCTION: Up-regulated at post-transcriptional level during survival
CC and slow-growth conditions. {ECO:0000269|PubMed:26787849}.
CC -!- DISRUPTION PHENOTYPE: Deletion mutant forms smaller biofilms, and
CC produces more pyocyanine and less phenazine-1-carboxylic acid (PCA)
CC than the wild-type. Affects expression of many genes and impacts
CC fitness in fluctuating conditions. {ECO:0000269|PubMed:26787849}.
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DR EMBL; CP000438; ABJ14670.1; -; Genomic_DNA.
DR RefSeq; WP_003096440.1; NZ_CP034244.1.
DR AlphaFoldDB; A0A0H2ZJC1; -.
DR EnsemblBacteria; ABJ14670; ABJ14670; PA14_69770.
DR KEGG; pau:PA14_69770; -.
DR HOGENOM; CLU_169698_0_0_6; -.
DR OMA; KKPTSDY; -.
DR BioCyc; PAER208963:G1G74-5879-MON; -.
DR Proteomes; UP000000653; Chromosome.
PE 1: Evidence at protein level;
KW Stress response; Transcription; Transcription regulation.
FT CHAIN 1..105
FT /note="Transcriptional regulator SutA"
FT /id="PRO_0000438366"
FT REGION 1..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..34
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 105 AA; 11198 MW; 0E081425214F2088 CRC64;
MSEEELEQDE LDGADEDDGE ELAAADDGEA DSSDGDEAPA PGKKAKAAVV EEELPSVEAK
QKERDALAKA MEEFLSRGGK VQEIEPNVVA DPPKKPDSKY GSRPI