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SUTR_ECOLI
ID   SUTR_ECOLI              Reviewed;         178 AA.
AC   P77626;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=HTH-type transcriptional regulator SutR {ECO:0000305};
DE   AltName: Full=Sulfur utilization regulator {ECO:0000303|PubMed:25406449};
GN   Name=sutR {ECO:0000303|PubMed:25406449}; Synonyms=ydcN;
GN   OrderedLocusNames=b1434, JW1430;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA   Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA   Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA   Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA   Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA   Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA   Wada C., Yamamoto Y., Horiuchi T.;
RT   "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 28.0-40.1 min region on the linkage map.";
RL   DNA Res. 3:363-377(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   FUNCTION, DNA-BINDING, AND INDUCTION.
RC   STRAIN=K12;
RX   PubMed=25406449; DOI=10.1099/mic.0.083550-0;
RA   Yamamoto K., Nakano M., Ishihama A.;
RT   "Regulatory role of transcription factor SutR (YdcN) in sulfur utilization
RT   in Escherichia coli.";
RL   Microbiology 161:99-111(2015).
CC   -!- FUNCTION: Regulates the expression of 12-16 transcription units
CC       involved in various steps of sulfur utilization. Represses expression
CC       of pfkB, fliZ, cysE, ydcO and its own expression. Activates expression
CC       of ypfN. Acts by binding to SutR boxes. {ECO:0000269|PubMed:25406449}.
CC   -!- INDUCTION: Negatively autoregulated. {ECO:0000269|PubMed:25406449}.
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DR   EMBL; U00096; AAC74516.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA15062.1; -; Genomic_DNA.
DR   PIR; E64895; E64895.
DR   RefSeq; NP_415951.1; NC_000913.3.
DR   RefSeq; WP_000429155.1; NZ_SSZK01000021.1.
DR   AlphaFoldDB; P77626; -.
DR   SMR; P77626; -.
DR   BioGRID; 4260184; 6.
DR   DIP; DIP-11649N; -.
DR   STRING; 511145.b1434; -.
DR   PaxDb; P77626; -.
DR   PRIDE; P77626; -.
DR   EnsemblBacteria; AAC74516; AAC74516; b1434.
DR   EnsemblBacteria; BAA15062; BAA15062; BAA15062.
DR   GeneID; 946000; -.
DR   KEGG; ecj:JW1430; -.
DR   KEGG; eco:b1434; -.
DR   PATRIC; fig|1411691.4.peg.835; -.
DR   eggNOG; COG1396; Bacteria.
DR   HOGENOM; CLU_085376_5_0_6; -.
DR   InParanoid; P77626; -.
DR   OMA; GMLIQIE; -.
DR   PhylomeDB; P77626; -.
DR   BioCyc; EcoCyc:G6745-MON; -.
DR   PRO; PR:P77626; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IDA:EcoCyc.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:EcoCyc.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:EcoCyc.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:EcoCyc.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:EcoCyc.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR013096; Cupin_2.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   Pfam; PF07883; Cupin_2; 1.
DR   Pfam; PF01381; HTH_3; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..178
FT                   /note="HTH-type transcriptional regulator SutR"
FT                   /id="PRO_0000149756"
FT   DOMAIN          12..66
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
SQ   SEQUENCE   178 AA;  19731 MW;  64AD5A4B42325855 CRC64;
     MENLARFLST TLKQLRQQRG WSLSRLAEAT GVSKAMLGQI ERNESSPTVA TLWKIATGLN
     VPFSTFISPP QSATPSVYDP QQQAMVITSL FPYDPQLCFE HFSIQMASGA ISESTPHEKG
     VIEHVVVIDG QLDLCVDGEW QTLNCGEGVR FAADVTHIYR NGGEQTVHFH SLIHYPRS
 
 
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