ID   SUUR_DROER              Reviewed;         962 AA.
AC   P59597;
DT   23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-APR-2003, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Protein suppressor of underreplication;
GN   Name=SuUR;
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Ovary;
RA   Yurlova A.A., Belyakin S.N., Makunin I.V., Zhimulev I.F.;
RT   "Cloning of Drosophila erecta SuUR gene.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for underreplication of DNA, which is found in many
CC       late replicating euchromatic regions of salivary gland polytene
CC       chromosomes. Controls chromatin organization in polytene chromosomes
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC       Note=Binds to polytene chromosomes from salivary glands. Localized at
CC       late-replicating intercalary heterochromatin and pericentric
CC       heterochromatin. Colocalizes with many Polycomb Group proteins binding
CC       sites on polytene chromosomes (By similarity). {ECO:0000250}.
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DR   EMBL; AJ539550; CAD62567.1; -; Genomic_DNA.
DR   AlphaFoldDB; P59597; -.
DR   SMR; P59597; -.
DR   STRING; 7220.FBpp0134019; -.
DR   PRIDE; P59597; -.
DR   eggNOG; ENOG502TBHQ; Eukaryota.
DR   GO; GO:0005725; C:intercalary heterochromatin; IEA:EnsemblMetazoa.
DR   GO; GO:0043596; C:nuclear replication fork; IEA:EnsemblMetazoa.
DR   GO; GO:0005721; C:pericentric heterochromatin; IEA:EnsemblMetazoa.
DR   GO; GO:0005700; C:polytene chromosome; IEA:EnsemblMetazoa.
DR   GO; GO:0003682; F:chromatin binding; IEA:EnsemblMetazoa.
DR   GO; GO:0042023; P:DNA endoreduplication; IEA:EnsemblMetazoa.
DR   GO; GO:0031507; P:heterochromatin assembly; IEA:EnsemblMetazoa.
DR   GO; GO:0045185; P:maintenance of protein location; IEA:EnsemblMetazoa.
DR   GO; GO:2000104; P:negative regulation of DNA-templated DNA replication; IEA:EnsemblMetazoa.
DR   GO; GO:0032877; P:positive regulation of DNA endoreduplication; IEA:EnsemblMetazoa.
DR   GO; GO:0034502; P:protein localization to chromosome; IEA:EnsemblMetazoa.
DR   Gene3D; 3.40.50.10810; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Chromosome; Developmental protein; Nucleus.
FT   CHAIN           1..962
FT                   /note="Protein suppressor of underreplication"
FT                   /id="PRO_0000072322"
FT   REGION          353..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          438..590
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          658..712
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          866..900
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          916..962
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..405
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        438..452
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        488..509
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        522..567
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        658..672
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        866..884
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        916..948
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   962 AA;  107467 MW;  C79A4E2BC52EF9D6 CRC64;
     MYHFVSEQTP ELRLSAEALV TSRVTQYLKS FQLDAVRFVY DRLAKREFCI LNDESGLGKV
     ATVAALLSAL PPAKKTLVVL QNDEQLLTGW RFHLDTLTDL QVYIIQGVHD TTDSPHSVYL
     AKWSQLRSIG DLSRLKFDYI MVDNRGHSLN NSFCTSMLLK QFEGRVNVLI SSVDITSDVK
     LLYNVLRLGD RLEHQYKSFS RFDRKFHLPD PKEVFSKRID LEEYYKQRGF LSEYIKDFRL
     RRFRHQFDKT LPLVAPEQYK HNLNLWLASK NSQSTLSGSE VCSTVASIEN NPPQQNETVL
     VEESDRISEH SVDDVVAMSP LIFESSESDD EPITVDPVAN ENPVLVVSSD DCEIVTPPNT
     PPNRTPLVNK SPRTKSKKKC SKKPSPCKEA DLTDSEKDDE GLTMPPRKST RAATVHFTPK
     TRRLNVRLLR VSLDALSTPT PSGATTAIIT PKTEPSARRK NRTKQPMDVG RPATRGMQRL
     TRSAESKINS KYLKHHVLDD AKRNFPRRIK AEGNQTPKTS KRIVKQESKA KAKPEQKKKI
     KTVDKPAQET PKRKPGRPRK CKTLTETLGK SKTKPNSKPL PPTPQVLSGS SLSSEYMQCA
     QRIPDDLDAI ESPAFRVPFT PQQTPMLLTL PSTHNLLNDS EVVAIPLFKD QVETVVINSS
     HDESSPQDPS QSRRTKALKR KRKPDAPVNS SFGGGLGLPQ AKRSATNKSP DLFSISSDLS
     QIPLAQPRPS SPFEGFKIFG SEVKQFQQQH AKVTIPAPKK KRDRSCLDIL EQMFEPRLQQ
     SSKTSPKVLP TLPLIQKDDA TTTFTQRRGT LLEDDFFEIT NNGQFGSRMR LNASGEVSPV
     QQDQQSVRPT QANKITNYLI GSVITQERTQ PSNGNRNSIV ASLRKSPKSP KHGARTTQAT
     KLTRWFGSVF GGGASQTSSV ESVSAPSTPV NPSTSAAACQ TRTARSGGAT GPTKRKRLEL
     FK