SUV37_DROME
ID SUV37_DROME Reviewed; 1250 AA.
AC P20193; Q9VFX7;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 4.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Protein suppressor of variegation 3-7;
GN Name=Su(var)3-7; Synonyms=Suvar(3)7; ORFNames=CG8599;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7708496; DOI=10.1093/nar/23.5.796;
RA Cleard F., Matsarskaia M., Spierer P.;
RT "The modifier of position-effect variegation Suvar(3)7 of Drosophila: there
RT are two alternative transcripts and seven scattered zinc fingers, each
RT preceded by a tryptophan box.";
RL Nucleic Acids Res. 23:796-802(1995).
RN [2]
RP ERRATUM OF PUBMED:7708496.
RA Cleard F., Matsarskaia M., Spierer P.;
RL Nucleic Acids Res. 23:3804-3804(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE OF 336-1250.
RX PubMed=2107402; DOI=10.1038/344219a0;
RA Reuter G., Giarre M., Farah J., Gausz J., Spierer A., Spierer P.;
RT "Dependence of position-effect variegation in Drosophila on dose of a gene
RT encoding an unusual zinc-finger protein.";
RL Nature 344:219-223(1990).
RN [6]
RP INTERACTION WITH SU(VAR)39.
RX PubMed=11867540; DOI=10.1093/emboj/21.5.1121;
RA Schotta G., Ebert A., Krauss V., Fischer A., Hoffmann J., Rea S.,
RA Jenuwein T., Dorn R., Reuter G.;
RT "Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and
RT heterochromatic gene silencing.";
RL EMBO J. 21:1121-1131(2002).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165; SER-175; SER-176;
RP SER-871; SER-873 AND SER-975, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Dose-limiting factor in position-effect variegation, the
CC inactivation in some cells of a gene translocated next to
CC heterochromatin. It could play a role in chromosome condensation.
CC -!- SUBUNIT: Interacts with Su(var)39 through the BESS domain.
CC {ECO:0000269|PubMed:11867540}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA36434.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X52187; CAA36434.1; ALT_FRAME; mRNA.
DR EMBL; AE014297; AAF54918.2; -; Genomic_DNA.
DR PIR; S09151; S09151.
DR RefSeq; NP_524342.3; NM_079618.4.
DR AlphaFoldDB; P20193; -.
DR BioGRID; 66711; 10.
DR ELM; P20193; -.
DR IntAct; P20193; 4.
DR STRING; 7227.FBpp0082204; -.
DR iPTMnet; P20193; -.
DR PaxDb; P20193; -.
DR PRIDE; P20193; -.
DR EnsemblMetazoa; FBtr0082736; FBpp0082204; FBgn0003598.
DR GeneID; 41627; -.
DR KEGG; dme:Dmel_CG8599; -.
DR CTD; 41627; -.
DR FlyBase; FBgn0003598; Su(var)3-7.
DR VEuPathDB; VectorBase:FBgn0003598; -.
DR eggNOG; ENOG502T8X0; Eukaryota.
DR InParanoid; P20193; -.
DR OrthoDB; 187004at2759; -.
DR PhylomeDB; P20193; -.
DR SignaLink; P20193; -.
DR BioGRID-ORCS; 41627; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Su(var)3-7; fly.
DR GenomeRNAi; 41627; -.
DR PRO; PR:P20193; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0003598; Expressed in eye disc (Drosophila) and 41 other tissues.
DR ExpressionAtlas; P20193; baseline and differential.
DR Genevisible; P20193; DM.
DR GO; GO:0000792; C:heterochromatin; IDA:FlyBase.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0005721; C:pericentric heterochromatin; IDA:FlyBase.
DR GO; GO:0003682; F:chromatin binding; IDA:FlyBase.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009047; P:dosage compensation by hyperactivation of X chromosome; IMP:FlyBase.
DR GO; GO:0006116; P:NADH oxidation; IBA:GO_Central.
DR GO; GO:0031453; P:positive regulation of heterochromatin assembly; IGI:FlyBase.
DR GO; GO:0090053; P:positive regulation of pericentric heterochromatin assembly; IMP:FlyBase.
DR InterPro; IPR004210; BESS_motif.
DR Pfam; PF02944; BESS; 1.
DR PROSITE; PS51031; BESS; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Zinc; Zinc-finger.
FT CHAIN 1..1250
FT /note="Protein suppressor of variegation 3-7"
FT /id="PRO_0000047060"
FT DOMAIN 987..1026
FT /note="BESS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00371"
FT ZN_FING 217..236
FT /note="C2H2-type 1"
FT ZN_FING 319..343
FT /note="C2H2-type 2"
FT ZN_FING 425..446
FT /note="C2H2-type 3"
FT ZN_FING 487..512
FT /note="C2H2-type 4"
FT ZN_FING 605..629
FT /note="C2H2-type 5"
FT ZN_FING 737..761
FT /note="C2H2-type 6"
FT ZN_FING 829..852
FT /note="C2H2-type 7"
FT REGION 107..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1154..1180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1205..1236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..680
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..896
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1057
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 165
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 175
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 176
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 871
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 873
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 975
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CONFLICT 53..54
FT /note="IE -> MQ (in Ref. 1; CAA36434)"
FT /evidence="ECO:0000305"
FT CONFLICT 265
FT /note="D -> S (in Ref. 1; CAA36434)"
FT /evidence="ECO:0000305"
FT CONFLICT 385
FT /note="V -> A (in Ref. 1; CAA36434)"
FT /evidence="ECO:0000305"
FT CONFLICT 943
FT /note="D -> N (in Ref. 1; CAA36434)"
FT /evidence="ECO:0000305"
FT CONFLICT 1148
FT /note="L -> V (in Ref. 1; CAA36434)"
FT /evidence="ECO:0000305"
FT CONFLICT 1159
FT /note="V -> A (in Ref. 1; CAA36434)"
FT /evidence="ECO:0000305"
FT CONFLICT 1193
FT /note="V -> A (in Ref. 1; CAA36434)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1250 AA; 139990 MW; 90D0338C894D074C CRC64;
MDRDSSMQAK NLDAQCNPDL KMASANSETL ASATHELKIM DVEGGALVDP DHIEEVETSM
VIVVDDDDGD VAMVVEEDKH PMRDDPCIED IMDDEHAPLV AELQSALNNP DDKQASEDPL
LEDQEREPDA MSTKTEPSSD AESSHSYHDP MGLLERIEIH DPGDSQDDDD EDDESSNGGG
VDGGMRRKMP RAQRWLLWMK RWPWILHEDS DGTLAFCLYC NISINVNNRS RHIQQHNVSL
SHQERECNYL AFKKSEEETR GAISDNEIKH EFGTKSYVAA MKQKRISETE AFNNFNWLRW
LRWHPWLERS MPTGTIGTCR ICSVRMNVEF VYLRKRHETT KGHMEALRNL DSDKRSRKRK
RSKSNSVTNS GGDEAEREKE SEPEVGPEDA QDTPVVMMNG DVDSGDDPGK WCALIPDTNP
QQCRCTLCNC TMAITSFLRH CKTRAHCHML STPAEKGSSD IRGIWAVFAD MHPWLIADPE
DPSIGYCSVC RKRFMYGNSE IKRKNHEKSE KHTLALASAK AGIEVGSADG RGGDNMDEEE
AAASDQAQSS QTDDSEDNDD DNWSEIQKLG KGFAHKSSSE PRKATVRAGV RFYPWLCYSK
DRKTQICKFC RVRFHNEAAK ARHELSARHV KLVKQFKMRQ AKLHQGTNTQ TKHNAQDDEE
SQEQDEEYGE EEEDAEEDSQ SNFDLGTVQA RKTARADNKL FVKPIPATMK GKVMVWKGRF
PWLSYKKNEQ RGNYAWCKLC EVSLYLPSSK WASKHQRTSR HIRLRIDRKR NGGNPLKTSN
KNSGEISTVV ATASALASAE ARQKAAMAEL QAKYDWLDPD ANDENHCHCR VCDSRLPIKV
FYLRQHDASR KHVENKERQR ANAAAAANAP SVSPTSTVDA ERQESGMDKE SENDMSVRSD
GSTAEPLAKR SRRSMEVRRI IRALRDSMGK RQEERSQMDM ARDMICSSFD IVTRLRTLER
ESVAHNESMA QAPPSVTVSP IKPPEPRHVM DLFFDSISPT MKSLPPDLAA EGKSKIMQLV
CSLELRAMQR NATTPTPATV SASSKWPSST TVTPVKTPPA PISAPLASVD ADLHSSVVTT
PHEYNNGQNN NNDKETVPKE PVTGASSAQV TINGSAKDLP ENIRRILTSN QTQVTNRLET
DSVRCVPLDK LTTQSRTNVN GRLSQGGTSE APSTPQADLS NGNTLAMIRQ IRVNNNNSSK
ITVTNTPQMQ QPQQAQASIT SSTPIMRGGP SSNGCQITTF RTMVNHNRRP
