SUV3_CAEEL
ID SUV3_CAEEL Reviewed; 719 AA.
AC Q17828; E9P872; Q2XN00;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-DEC-2020, sequence version 3.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=ATP-dependent RNA helicase SUV3 homolog, mitochondrial;
DE EC=3.6.4.13 {ECO:0000250|UniProtKB:Q8IYB8};
DE Flags: Precursor;
GN ORFNames=C08F8.2 {ECO:0000312|WormBase:C08F8.2b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: ATPase and DNA/RNA helicase able to unwind DNA/DNA, DNA/RNA
CC and RNA/RNA duplexes in the 5'-3' direction.
CC {ECO:0000250|UniProtKB:Q8IYB8}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000250|UniProtKB:Q8IYB8};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000250|UniProtKB:Q8IYB8};
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000250|UniProtKB:Q8IYB8};
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000250|UniProtKB:Q8IYB8}. Nucleus {ECO:0000250|UniProtKB:Q8IYB8}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b {ECO:0000312|WormBase:C08F8.2b};
CC IsoId=Q17828-1; Sequence=Displayed;
CC Name=c {ECO:0000312|WormBase:C08F8.2c};
CC IsoId=Q17828-2; Sequence=VSP_060781;
CC -!- SIMILARITY: Belongs to the helicase family. {ECO:0000305}.
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DR EMBL; BX284604; CAJ43433.1; -; Genomic_DNA.
DR EMBL; BX284604; CBZ01775.1; -; Genomic_DNA.
DR PIR; T19103; T19103.
DR RefSeq; NP_001040911.1; NM_001047446.4.
DR RefSeq; NP_001040912.1; NM_001047447.2. [Q17828-1]
DR RefSeq; NP_001255542.1; NM_001268613.1. [Q17828-2]
DR AlphaFoldDB; Q17828; -.
DR SMR; Q17828; -.
DR BioGRID; 43121; 1.
DR IntAct; Q17828; 1.
DR STRING; 6239.C08F8.2a; -.
DR EPD; Q17828; -.
DR PaxDb; Q17828; -.
DR PeptideAtlas; Q17828; -.
DR EnsemblMetazoa; C08F8.2b.1; C08F8.2b.1; WBGene00007444. [Q17828-1]
DR EnsemblMetazoa; C08F8.2c.1; C08F8.2c.1; WBGene00007444. [Q17828-2]
DR GeneID; 178022; -.
DR KEGG; cel:CELE_C08F8.2; -.
DR UCSC; C08F8.2a; c. elegans. [Q17828-1]
DR CTD; 178022; -.
DR WormBase; C08F8.2b; CE05249; WBGene00007444; -. [Q17828-1]
DR WormBase; C08F8.2c; CE45714; WBGene00007444; -. [Q17828-2]
DR eggNOG; KOG0953; Eukaryota.
DR GeneTree; ENSGT00390000003100; -.
DR HOGENOM; CLU_010647_3_2_1; -.
DR InParanoid; Q17828; -.
DR OrthoDB; 1106167at2759; -.
DR PhylomeDB; Q17828; -.
DR PRO; PR:Q17828; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00007444; Expressed in germ line (C elegans) and 4 other tissues.
DR ExpressionAtlas; Q17828; baseline and differential.
DR GO; GO:0045025; C:mitochondrial degradosome; IBA:GO_Central.
DR GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0003678; F:DNA helicase activity; ISS:UniProtKB.
DR GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR GO; GO:0032508; P:DNA duplex unwinding; ISS:UniProtKB.
DR GO; GO:0000965; P:mitochondrial RNA 3'-end processing; IBA:GO_Central.
DR GO; GO:0006401; P:RNA catabolic process; IBA:GO_Central.
DR CDD; cd17913; DEXQc_Suv3; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR022192; SUV3_C.
DR InterPro; IPR041082; Suv3_C_1.
DR InterPro; IPR044774; Suv3_DEXQc.
DR InterPro; IPR041453; Suv3_N.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF12513; SUV3_C; 1.
DR Pfam; PF18147; Suv3_C_1; 1.
DR Pfam; PF18114; Suv3_N; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Alternative splicing; ATP-binding; Coiled coil; Helicase; Hydrolase;
KW Mitochondrion; Nucleotide-binding; Nucleus; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..18
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 19..719
FT /note="ATP-dependent RNA helicase SUV3 homolog,
FT mitochondrial"
FT /id="PRO_0000310551"
FT DOMAIN 181..319
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 343..499
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 16..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 693..717
FT /evidence="ECO:0000255"
FT COMPBIAS 16..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..692
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 194..201
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT VAR_SEQ 1..281
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_060781"
SQ SEQUENCE 719 AA; 81010 MW; 905BB5A4F68BEF87 CRC64;
MRRASGVLRV LGGLTQRCST SSTPSSSRFP AMNSRRKRNS VRKTATIEDI VEPRKVKHVT
QTAAGMGEWI GSLDNTNIHM SLDEFMRRPM VRQLAKENGI NDKLFMRSFK SFREYCTPED
LNSVDPGLLI LLSDISKGTK DCEMLYPFFL DHAKQVFPHL EAMDDLRIIS DLTRPHNWYP
EARSVTRKIF FHAGPTNSGK TYHALKRFGE AKSAVFCGPL KLLAAEVFHR TNELGIPCDL
VTGEERRFAK DNHHPSQHLS STVEMLSTQM RVEVAVIDEI QMLRDEQRGW AWTRALLGAA
ADEIHLCGEP AAIDIVKKLL EPIGETVEVR YYERKSPLAI ADKAIESYSN IEPGDCIVCF
SKRSIFFNSK KLEENGIKPA VIYGDLPPGT KLAQAAKFND PDDECNVLVA TDAIGMGLNL
NIRRVIFNSC TRQTELLPTY AALQIAGRAG RFGTAYANGV ATTMRKEDLG TLKAILSEKI
EPIANVGIAP TYDQIETFSF HLPQASFVRL LDLFVSVCSV SDHFFICTVY DMRELAVLID
QIPLPLKVRY TFCTSPLNTE DKRTSAVFVK MARRFSTGQA LTYEWLIDML EWPPKPATTL
NELSLLEQNY EILDQYMWLS MRFPDMLPDE PRVREASKHL DSMIQEGVES FMSLLSVGAT
ESKAAGSSKS SEGKRENPSK SEREKPNKRS SILEALLKRA DISEDDLEQL REELNKNKK
