ID   SUV3_SACPA              Reviewed;         737 AA.
AC   O74727;
DT   09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=ATP-dependent RNA helicase SUV3, mitochondrial;
DE            EC=3.6.4.13;
DE   Flags: Precursor;
GN   Name=SUV3;
OS   Saccharomyces paradoxus (Yeast) (Saccharomyces douglasii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=27291;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=CX1;
RX   PubMed=14734028; DOI=10.1016/s1567-1356(03)00160-0;
RA   Golik P., Zwolinska U., Stepien P.P., Lazowska J.;
RT   "The SUV3 gene from Saccharomyces douglasii is a functional equivalent of
RT   its Saccharomyces cerevisiae orthologue and is essential for respiratory
RT   growth.";
RL   FEMS Yeast Res. 4:477-485(2004).
CC   -!- FUNCTION: Probable ATP-dependent RNA helicase involved in a variety of
CC       mitochondrial post-transcriptional processes and in translation. It is
CC       a key control element in nuclear-mitochondrial interactions.
CC       {ECO:0000269|PubMed:14734028}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the helicase family. {ECO:0000305}.
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DR   EMBL; AJ011586; CAA09716.1; -; Genomic_DNA.
DR   AlphaFoldDB; O74727; -.
DR   SMR; O74727; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   CDD; cd17913; DEXQc_Suv3; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR022192; SUV3_C.
DR   InterPro; IPR044774; Suv3_DEXQc.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF12513; SUV3_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Mitochondrion; Nucleotide-binding;
KW   RNA-binding; Transit peptide.
FT   TRANSIT         1..25
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..737
FT                   /note="ATP-dependent RNA helicase SUV3, mitochondrial"
FT                   /id="PRO_0000013305"
FT   DOMAIN          226..365
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          390..546
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   BINDING         239..246
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   737 AA;  84283 MW;  E24DD4C2097CA961 CRC64;
     MTLVKYSTIA FPLRSFRLFI FVKKALYHNE PHSIDPFHDK NWIVKRPKFL NLPKNEHSKL
     DVFQFNFNKS KSNNVYLRDP LFRDNLDKAM QIIYNEKLSS LDAKQVPIKN LAWLKLRDSI
     YQQLEDPKQQ TKNYVPSISE IIYPSSPGNL ISLLINCNKI GNSVWKSILK NGQSNNISTL
     DKFIHVLQQT FDHMYEQEIL PMMTNTDDTD GAHNVDITNP AEWFSEARKI RRHIIMHIGP
     TNSGKTYRAL QKLKSVDRGY YAGPLRLLAR EVYDRFQSEK VRCNLLTGEE VIRDLDDKGN
     PAGLTSGTVE MVPINQKFDV VVLDEIQMMS DADRGWAWTN ALLGVVSKEV HLVGEKSVLP
     LVKSIVKMTG DKLTINEYER LGKLSVEDKP VKDGIKGLRK GDCVVAFSKK KVLDLKLKIE
     KDTNLKVAVI YGSLPPETRV QQAALFNNGE YDIMVASDAI GMGLNLSIDR VVFTTNMKYN
     GEELMEMTSS QIKQIGGRAG RFKSKSTSGG VPQGFITSFE SKVLKSVRKA IESPIEYLKT
     AVTWPTDEIC AQLMTQFPPG TPTSDLLQTI SDELERSSDN LFTLSDLKSK LKVIGLFEHM
     EDIPFFDKLK LSNAPVKDMP MVTKAFTKFC ETIAKRHTRG LLSYRLPFNL LDYNCIPNES
     YSLEVYESLY NIITLYFWLS NRYPNYFIDM ESAKDLKYFC EMIIFEKLDR LKKNPYAHKP
     FGSTRGQFPS SRGRLRT