SUVHA_ARATH
ID SUVHA_ARATH Reviewed; 312 AA.
AC Q3EC60; V9H0G5;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Putative inactive histone-lysine N-methyltransferase family member SUVH10;
DE AltName: Full=Histone H3-K9 methyltransferase 10;
DE Short=H3-K9-HMTase 10;
DE AltName: Full=Protein SET DOMAIN GROUP 11;
DE AltName: Full=Suppressor of variegation 3-9 homolog protein 10;
DE Short=Su(var)3-9 homolog protein 10;
GN Name=SUVH10; Synonyms=SDG11, SET11; OrderedLocusNames=At2g05900;
GN ORFNames=T6P5.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NOMENCLATURE.
RX PubMed=11691919; DOI=10.1093/nar/29.21.4319;
RA Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K.,
RA Assalkhou R., Schulz I., Reuter G., Aalen R.B.;
RT "The Arabidopsis thaliana genome contains at least 29 active genes encoding
RT SET domain proteins that can be assigned to four evolutionarily conserved
RT classes.";
RL Nucleic Acids Res. 29:4319-4333(2001).
RN [4]
RP GENE FAMILY.
RX PubMed=16384625; DOI=10.1016/j.jplph.2005.10.015;
RA Fischer A., Hofmann I., Naumann K., Reuter G.;
RT "Heterochromatin proteins and the control of heterochromatic gene silencing
RT in Arabidopsis.";
RL J. Plant Physiol. 163:358-368(2006).
CC -!- FUNCTION: Histone methyltransferase family member that may lack
CC methyltransferase activity. May methylate 'Lys-9' of histone H3. H3
CC 'Lys-9' methylation represents a specific tag for epigenetic
CC transcriptional repression (Potential). {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00358}.
CC Chromosome, centromere {ECO:0000250}. Note=Associates with centromeric
CC constitutive heterochromatin. {ECO:0000250}.
CC -!- DOMAIN: Although both SET and pre-SET domains are present, the absence
CC of the post-SET domain may alter the methyltransferase activity.
CC -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC superfamily. Histone-lysine methyltransferase family. Suvar3-9
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
CC -!- CAUTION: The S-adenosyl-L-methionine binding sites are not conserved,
CC suggesting that this protein lacks methyltransferase activity.
CC Likewise, the zinc-binding Cys residues in the pre-SET domain are only
CC partially conserved. {ECO:0000305}.
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DR EMBL; AC005970; AAC95167.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC05982.1; -; Genomic_DNA.
DR PIR; G84472; G84472.
DR RefSeq; NP_178647.1; NM_126603.1.
DR AlphaFoldDB; Q3EC60; -.
DR SMR; Q3EC60; -.
DR BioGRID; 541; 6.
DR IntAct; Q3EC60; 3.
DR STRING; 3702.AT2G05900.1; -.
DR PaxDb; Q3EC60; -.
DR PRIDE; Q3EC60; -.
DR EnsemblPlants; AT2G05900.1; AT2G05900.1; AT2G05900.
DR GeneID; 815142; -.
DR Gramene; AT2G05900.1; AT2G05900.1; AT2G05900.
DR KEGG; ath:AT2G05900; -.
DR Araport; AT2G05900; -.
DR TAIR; locus:2064676; AT2G05900.
DR eggNOG; KOG1082; Eukaryota.
DR HOGENOM; CLU_892394_0_0_1; -.
DR InParanoid; Q3EC60; -.
DR OMA; DMEFIGV; -.
DR OrthoDB; 1183452at2759; -.
DR PhylomeDB; Q3EC60; -.
DR PRO; PR:Q3EC60; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q3EC60; differential.
DR Genevisible; Q3EC60; AT.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR Gene3D; 2.170.270.10; -; 2.
DR Gene3D; 2.30.280.10; -; 1.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036987; SRA-YDG_sf.
DR InterPro; IPR003105; SRA_YDG.
DR Pfam; PF02182; SAD_SRA; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SMART; SM00466; SRA; 1.
DR SUPFAM; SSF82199; SSF82199; 1.
DR SUPFAM; SSF88697; SSF88697; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS51015; YDG; 1.
PE 3: Inferred from homology;
KW Centromere; Chromatin regulator; Chromosome; Metal-binding; Nucleus;
KW Reference proteome; Zinc.
FT CHAIN 1..312
FT /note="Putative inactive histone-lysine N-methyltransferase
FT family member SUVH10"
FT /id="PRO_0000233364"
FT DOMAIN 1..132
FT /note="YDG"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00358"
FT DOMAIN 126..290
FT /note="SET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT DOMAIN 163..219
FT /note="Pre-SET"
FT DOMAIN 296..312
FT /note="Post-SET"
FT BINDING 250
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT BINDING 300
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT BINDING 302
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT BINDING 307
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
SQ SEQUENCE 312 AA; 35023 MW; 9349BB5A6D07CCB6 CRC64;
MGLVGLHSGT IDMEFIGVED HGDEEGKQIA VSVISSGKNA DKTEDPDSLI FTGFGGTDMY
HGQPCNQKLE RLNIPLEAAF RKKSIVRVVR CMKDEKRTNG NIYIYDGTYM ITNRWEEEGQ
NGFIVFKFKL VREPDQKPAF GIWKSIQNWR NGLSIRPGLI LEDLSNGAEN LKVCLVNEVD
KENGPALFRY VTSLIHEVIN NIPSMVDRCA CGRRSCGSKH VFREKLSVSS SLVISAKKSG
NVARFMNHSC SPNVFWQSIA REQNGLWCLY IGFFAMKHIP PLTELRYDYG KSRGGGKKMC
LCRTKKCCGS FG
