ID   SUZ12_XENTR             Reviewed;         700 AA.
AC   Q0VA03;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Polycomb protein suz12;
DE   AltName: Full=Suppressor of zeste 12 protein homolog;
GN   Name=suz12;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Polycomb group (PcG) protein. Component of the prc2/eed-ezh2
CC       complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of
CC       histone H3, leading to transcriptional repression of the affected
CC       target gene (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the prc2/eed-ezh2 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
CC       {ECO:0000305}.
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DR   EMBL; BC121323; AAI21324.1; -; mRNA.
DR   RefSeq; NP_001072292.1; NM_001078824.1.
DR   AlphaFoldDB; Q0VA03; -.
DR   SMR; Q0VA03; -.
DR   STRING; 8364.ENSXETP00000061138; -.
DR   PaxDb; Q0VA03; -.
DR   PRIDE; Q0VA03; -.
DR   GeneID; 779745; -.
DR   KEGG; xtr:779745; -.
DR   CTD; 23512; -.
DR   Xenbase; XB-GENE-997462; suz12.
DR   eggNOG; KOG2350; Eukaryota.
DR   InParanoid; Q0VA03; -.
DR   OrthoDB; 516359at2759; -.
DR   Reactome; R-XTR-212300; PRC2 methylates histones and DNA.
DR   Reactome; R-XTR-2559580; Oxidative Stress Induced Senescence.
DR   Reactome; R-XTR-3214841; PKMTs methylate histone lysines.
DR   Reactome; R-XTR-4551638; SUMOylation of chromatin organization proteins.
DR   Reactome; R-XTR-8943724; Regulation of PTEN gene transcription.
DR   Proteomes; UP000008143; Chromosome 10.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   InterPro; IPR019135; Polycomb_protein_VEFS-Box.
DR   Pfam; PF09733; VEFS-Box; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Metal-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..700
FT                   /note="Polycomb protein suz12"
FT                   /id="PRO_0000343753"
FT   ZN_FING         405..428
FT                   /note="C2H2-type"
FT   REGION          215..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          319..376
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          520..596
FT                   /note="VEFS-box"
FT   REGION          651..700
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..247
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..363
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        660..677
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   700 AA;  80365 MW;  BF7B4812425172F6 CRC64;
     MAPQKHGGSS APSGKPSAAA SLLPVRKPKM EQIQADHELF LQAFEKPTQI YRFLRTRNLI
     APIFLHRTLT YMSHRNSRSN AKRKTFKVND LLLKVEKMKG DQESHSVSAH LQLTFTGFFH
     KIDKPSQNSE NEQSSVTLEV LLVKVCHKKR KDVSCPIRQV PTGKKQVPLN PELNPAKPST
     FPSLAVSSNE FEPSNSHMVK SYSLLFRVTR QGRRDFNGLT NGETNENIDV SEEPPARRKR
     NSSNRDEGDK TFVAQMTVFD KNRRLQLLDG EYEVAMQEME DCPVNKKRAT WETILDGKRL
     PPFETFSQGP TLQFTLRWTN DTPDKSTAPI AKPLATRNSE SLPQEHKPSS VKPAQTVAVK
     ESLSSDLQAR KERDVSSEPR QKLRIFYQFL YNNNTRQQTE ARDDLHCPWC TLNCRKLYSL
     LKHLKLCHSR FIFNYVYHPK GARIDVSINE CYDGSYAGNP QDIHRQPGFA FSRNGPVKRT
     PITHILVCRP KRTKASMSEF LESEDGEVEQ QRTYSSGHNR LYFHSDTCLP LRPQEMDVDS
     EDEKDPEWLR EKTITQIEEF SDVNEGEKEV MKMWNLHVMK HGFIADNQMN HGCMLFVDNY
     GPQIIQKNLC RNFMLHLVSM HDFNLISITT IDKAVSRLRE IQQKVERDEC LAPPSDEAFE
     EPNRTTSSSS SFMETNGKDR VVENDCVSGQ PPKHSKKQKP