SUZ2_DROME
ID SUZ2_DROME Reviewed; 1368 AA.
AC P25172; Q9V6J0;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Protein suppressor 2 of zeste;
DE AltName: Full=Protein posterior sex combs;
GN Name=Su(z)2; ORFNames=CG3905;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=Canton-S; TISSUE=Embryo;
RX PubMed=2057369; DOI=10.1093/nar/19.11.3149;
RA Brunk B.P., Adler P.N.;
RT "The sequence of the Drosophila regulatory gene Suppressor two of zeste.";
RL Nucleic Acids Res. 19:3149-3149(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Regulates expression of the homeotic selector genes by
CC influencing higher-order chromatin structure through interaction with
CC other proteins. {ECO:0000269|PubMed:2057369}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; X56798; CAA40134.1; -; Genomic_DNA.
DR EMBL; X56799; CAA40135.1; -; mRNA.
DR EMBL; AE013599; AAF58433.1; -; Genomic_DNA.
DR PIR; S14871; S14871.
DR RefSeq; NP_001163134.1; NM_001169663.3.
DR RefSeq; NP_523726.2; NM_079002.3.
DR AlphaFoldDB; P25172; -.
DR SMR; P25172; -.
DR BioGRID; 62202; 18.
DR IntAct; P25172; 1.
DR STRING; 7227.FBpp0289616; -.
DR PaxDb; P25172; -.
DR PRIDE; P25172; -.
DR EnsemblMetazoa; FBtr0087793; FBpp0086906; FBgn0265623.
DR EnsemblMetazoa; FBtr0300387; FBpp0289616; FBgn0265623.
DR GeneID; 36432; -.
DR KEGG; dme:Dmel_CG3905; -.
DR CTD; 36432; -.
DR FlyBase; FBgn0265623; Su(z)2.
DR VEuPathDB; VectorBase:FBgn0265623; -.
DR eggNOG; KOG2660; Eukaryota.
DR GeneTree; ENSGT00940000173039; -.
DR HOGENOM; CLU_251917_0_0_1; -.
DR InParanoid; P25172; -.
DR OMA; PDCKASG; -.
DR OrthoDB; 1203951at2759; -.
DR PhylomeDB; P25172; -.
DR Reactome; R-DME-2559580; Oxidative Stress Induced Senescence.
DR Reactome; R-DME-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-DME-3899300; SUMOylation of transcription cofactors.
DR Reactome; R-DME-4570464; SUMOylation of RNA binding proteins.
DR Reactome; R-DME-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
DR Reactome; R-DME-8943724; Regulation of PTEN gene transcription.
DR Reactome; R-DME-8953750; Transcriptional Regulation by E2F6.
DR SignaLink; P25172; -.
DR BioGRID-ORCS; 36432; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 36432; -.
DR PRO; PR:P25172; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0265623; Expressed in brain and 23 other tissues.
DR ExpressionAtlas; P25172; baseline and differential.
DR Genevisible; P25172; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0035102; C:PRC1 complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IDA:FlyBase.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; ISM:FlyBase.
DR GO; GO:0031507; P:heterochromatin assembly; IDA:FlyBase.
DR GO; GO:0036353; P:histone H2A-K119 monoubiquitination; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0031062; P:positive regulation of histone methylation; IMP:UniProtKB.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR032443; RAWUL.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF16207; RAWUL; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..1368
FT /note="Protein suppressor 2 of zeste"
FT /id="PRO_0000056389"
FT ZN_FING 35..74
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 245..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1116..1142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1161..1193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1298..1322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..282
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..510
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..983
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 19
FT /note="A -> T (in Ref. 1; CAA40134/CAA40135)"
FT /evidence="ECO:0000305"
FT CONFLICT 425
FT /note="L -> S (in Ref. 1; CAA40134/CAA40135)"
FT /evidence="ECO:0000305"
FT CONFLICT 613..615
FT /note="QPQ -> P (in Ref. 1; CAA40134)"
FT /evidence="ECO:0000305"
FT CONFLICT 615
FT /note="Missing (in Ref. 1; CAA40135)"
FT /evidence="ECO:0000305"
FT CONFLICT 691
FT /note="L -> M (in Ref. 1; CAA40134/CAA40135)"
FT /evidence="ECO:0000305"
FT CONFLICT 786
FT /note="K -> N (in Ref. 1; CAA40134)"
FT /evidence="ECO:0000305"
FT CONFLICT 832
FT /note="A -> R (in Ref. 1; CAA40134)"
FT /evidence="ECO:0000305"
FT CONFLICT 966
FT /note="Missing (in Ref. 1; CAA40134)"
FT /evidence="ECO:0000305"
FT CONFLICT 1066
FT /note="D -> E (in Ref. 1; CAA40134)"
FT /evidence="ECO:0000305"
FT CONFLICT 1078..1079
FT /note="Missing (in Ref. 1; CAA40135)"
FT /evidence="ECO:0000305"
FT CONFLICT 1290
FT /note="A -> P (in Ref. 1; CAA40134)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1368 AA; 146393 MW; 459FB6846FF3EDCD CRC64;
MHLQNTHNTM ESNAAMDAAS PASRDVRQFH DLITCRLCRG YMIDPTTVDY CYHTYCRSCI
LKHLLRAVYC PECKASGGKE INELNLKSDD TLRSLIYKLV PGLYQRECKE LADFKEQHDL
VDEQTTDEPE FFTTTELISL SLEYHPAMLH QCGPGEVPPT IYLQCAAGLP VELLKRFLCS
KYNIETDNGL VEVEVTYKDE VLPTNFTLMD VAYCYNWSRE SPMAFCYRIL LYDNEQTKND
ENNLSRINQD IEPEHSVRRS KSAKSVTFAE DLESEIDSGS PRSKVRCKTP PKVSPSSKNK
RLTSSKREAE PESPVSNFKS LRSNDMRYSD YAVSKVKSEP EQEQFLLPRE REQQPLEANT
NIVVSIPPSQ LRKSYVDAED FELKTANRKG VGHLPKLKIE LNSMKSKLSM PLSAGPRLED
TSCSLSCSAQ QLDLETYAKN IGLKPIEQPL QQSASNPDSK YSPNASPMSS CSSSTNGSSS
SLGTADASTS TSTSSSHRKR KKKHSKEPKD ANGKRKKLHA EISSQTDGKM KVKITAKPNH
KLDFKRSHSL ASGELDLQKL KLDSTSTSEA LNRTLGEEAR SINSLVVGGA PTPPPTPTAE
PEQQQQQQQQ QQQPQQQQQQ QQQQQQQQQF VVLPKIKDLT LPTSPPLPPS LFKAYTPSTT
PTAPHTVAGG KPKQQQQQMP QQPQAVLQQS LAKTNPAKPP LSSNNNRKPN SGHFAVPQAP
THRNMYHMQR YQSTPSSIAS AANKMPKRSM SLDESHPAKQ ARLSQAQAMA SSYAAKLHMQ
TSNQAKSQAA AFLPNPQMRS YGLPDLGSKP TLPMLCPASS SSQVTITPRP RATPSIYSFS
EPNIHVPALE IVRLPVNKQS AGGKGLTMPP LSPPATSSAR LMGPPAALPK HAGHGHGAAK
RSCQMPTMPM PLPLPLPMPM TTIPAIVKSP PLSVALSGQR NNKGNSSNSN AYRTSPPALI
NLRNTAAPQH SFPSKSSPKV EANSKKSPPA AGCQGKTNGT AALDKSKTSL REFRPAVQSA
VTATATTSVT TAAGAGAGAG TGTGTALAKD ADILDLSANP GRSNNDAKLA PNSPPAGNNN
NNNNNNNNNN NNNNNNNNNS TSNSLEAALN KIKQNISANS NGGPSTTSGS NSNGTTNGDD
LQNLHMLSES ATAREKISIK AASSGNGSGS TSSSSAKPKN ANALVRPQNA SVRSIPNPSA
LAFRNQPAAA STAASISKPL TVRAEEKPKV STSNPGSLSP TNTSSSSSSS SSGSSGCSAA
TSPRAMTKKP TTIDQVAANL NIRAEAKAAA LAEEAPPVLS SNAAKSPELA KTTTAVALRP
EPKETPITVS AASTLLTIPS AVSSVSAVPE TMAKPPVQIA NAPVASSA
