ID   SVBP_RAT                Reviewed;          66 AA.
AC   Q4KLG3;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Small vasohibin-binding protein {ECO:0000250|UniProtKB:Q8N300};
DE   AltName: Full=Coiled coil domain-containing protein 23 {ECO:0000312|RGD:1311232};
GN   Name=Svbp {ECO:0000250|UniProtKB:Q8N300};
GN   Synonyms=Ccdc23 {ECO:0000312|RGD:1311232};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   FUNCTION.
RX   PubMed=30607023; DOI=10.1038/s41436-018-0415-8;
RA   Iqbal Z., Tawamie H., Ba W., Reis A., Halak B.A., Sticht H., Uebe S.,
RA   Kasri N.N., Riazuddin S., van Bokhoven H., Abou Jamra R.;
RT   "Loss of function of SVBP leads to autosomal recessive intellectual
RT   disability, microcephaly, ataxia, and hypotonia.";
RL   Genet. Med. 21:1790-1796(2019).
CC   -!- FUNCTION: Enhances the tyrosine carboxypeptidase activity of VASH1 and
CC       VASH2, thereby promoting the removal of the C-terminal tyrosine residue
CC       of alpha-tubulin. Also required to enhance the solubility and secretion
CC       of VASH1 and VASH2. Plays a role in axon and excitatory synapse
CC       formation (PubMed:30607023). {ECO:0000250|UniProtKB:Q8N300,
CC       ECO:0000269|PubMed:30607023}.
CC   -!- SUBUNIT: Interacts with VASH1 and VASH2.
CC       {ECO:0000250|UniProtKB:Q8N300}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99LQ4}.
CC       Secreted {ECO:0000250|UniProtKB:Q99LQ4}. Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q8N300}. Note=Detected both intracellularly and
CC       extracellularly. Within cells, localizes mainly to the apical part of
CC       the cell. {ECO:0000250|UniProtKB:Q99LQ4}.
CC   -!- SIMILARITY: Belongs to the SVBP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC099226; AAH99226.1; -; mRNA.
DR   RefSeq; NP_001034081.1; NM_001038992.1.
DR   RefSeq; NP_001034083.1; NM_001038994.2.
DR   AlphaFoldDB; Q4KLG3; -.
DR   SMR; Q4KLG3; -.
DR   STRING; 10116.ENSRNOP00000009879; -.
DR   PaxDb; Q4KLG3; -.
DR   GeneID; 362578; -.
DR   KEGG; rno:362578; -.
DR   CTD; 374969; -.
DR   RGD; 1311232; Svbp.
DR   eggNOG; ENOG502S99I; Eukaryota.
DR   HOGENOM; CLU_2830589_0_0_1; -.
DR   InParanoid; Q4KLG3; -.
DR   OrthoDB; 1531949at2759; -.
DR   PRO; PR:Q4KLG3; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000007404; Expressed in testis and 20 other tissues.
DR   ExpressionAtlas; Q4KLG3; baseline and differential.
DR   Genevisible; Q4KLG3; RN.
DR   GO; GO:0045177; C:apical part of cell; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   GO; GO:0061564; P:axon development; ISS:UniProtKB.
DR   GO; GO:0010596; P:negative regulation of endothelial cell migration; ISO:RGD.
DR   GO; GO:0031397; P:negative regulation of protein ubiquitination; ISO:RGD.
DR   GO; GO:0009306; P:protein secretion; ISO:RGD.
DR   GO; GO:0006508; P:proteolysis; ISS:UniProtKB.
DR   GO; GO:1905048; P:regulation of metallopeptidase activity; ISS:UniProtKB.
DR   InterPro; IPR031378; SVBP.
DR   PANTHER; PTHR34762; PTHR34762; 1.
DR   Pfam; PF15674; CCDC23; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome; Secreted.
FT   CHAIN           1..66
FT                   /note="Small vasohibin-binding protein"
FT                   /id="PRO_0000233665"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          5..52
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   66 AA;  7836 MW;  9C0F238316F33CC8 CRC64;
     MDPPARKEKS KVKEPAFRVE KAKQKSAQQE LKQRQRAEIY ALNRVMTELE QQQFDEFCKQ
     MQPPGE