SVEP1_RAT
ID SVEP1_RAT Reviewed; 3564 AA.
AC P0C6B8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1;
DE Flags: Precursor;
GN Name=Svep1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP INDUCTION.
RX PubMed=17139625; DOI=10.1002/jcp.20895;
RA Shur I., Zemer-Tov E., Socher R., Benayahu D.;
RT "SVEP1 expression is regulated in estrogen-dependent manner.";
RL J. Cell. Physiol. 210:732-739(2007).
CC -!- FUNCTION: May play a role in the cell attachment process.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Cytoplasm {ECO:0000250}.
CC Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- INDUCTION: Estrogen-dependent; induced upon 17betaE2 treatment in
CC cultured osteoblasts (at protein level). {ECO:0000269|PubMed:17139625}.
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DR EMBL; AABR03040659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03041327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03041522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03042206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03044351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03044745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03045322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10116.ENSRNOP00000050549; -.
DR CarbonylDB; P0C6B8; -.
DR GlyGen; P0C6B8; 2 sites.
DR PaxDb; P0C6B8; -.
DR UCSC; RGD:1588987; rat.
DR RGD; 1588987; Svep1.
DR eggNOG; KOG1217; Eukaryota.
DR eggNOG; KOG4297; Eukaryota.
DR InParanoid; P0C6B8; -.
DR PhylomeDB; P0C6B8; -.
DR PRO; PR:P0C6B8; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0031012; C:extracellular matrix; IEA:UniProt.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; ISO:RGD.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0008544; P:epidermis development; ISO:RGD.
DR GO; GO:0010467; P:gene expression; ISO:RGD.
DR GO; GO:0003017; P:lymph circulation; ISO:RGD.
DR GO; GO:0001945; P:lymph vessel development; ISO:RGD.
DR GO; GO:0036303; P:lymph vessel morphogenesis; ISO:RGD.
DR GO; GO:0048014; P:Tie signaling pathway; ISO:RGD.
DR GO; GO:0120193; P:tight junction organization; ISO:RGD.
DR CDD; cd00033; CCP; 32.
DR CDD; cd00152; PTX; 1.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR003410; HYR_dom.
DR InterPro; IPR001759; Pentraxin-related.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF00008; EGF; 6.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 4.
DR Pfam; PF02494; HYR; 2.
DR Pfam; PF00354; Pentaxin; 1.
DR Pfam; PF00084; Sushi; 32.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR00895; PENTAXIN.
DR SMART; SM00032; CCP; 34.
DR SMART; SM00181; EGF; 11.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00159; PTX; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR SUPFAM; SSF57184; SSF57184; 3.
DR SUPFAM; SSF57535; SSF57535; 33.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS00022; EGF_1; 9.
DR PROSITE; PS01186; EGF_2; 11.
DR PROSITE; PS50026; EGF_3; 9.
DR PROSITE; PS01187; EGF_CA; 6.
DR PROSITE; PS50825; HYR; 2.
DR PROSITE; PS51828; PTX_2; 1.
DR PROSITE; PS50923; SUSHI; 34.
DR PROSITE; PS50234; VWFA; 1.
PE 1: Evidence at protein level;
KW Calcium; Cell adhesion; Cytoplasm; Disulfide bond; EGF-like domain;
KW Glycoprotein; Membrane; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..3564
FT /note="Sushi, von Willebrand factor type A, EGF and
FT pentraxin domain-containing protein 1"
FT /id="PRO_0000320180"
FT DOMAIN 84..265
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT DOMAIN 377..436
FT /note="Sushi 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 437..496
FT /note="Sushi 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 497..561
FT /note="Sushi 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 560..644
FT /note="HYR 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT DOMAIN 645..724
FT /note="HYR 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT DOMAIN 725..789
FT /note="Sushi 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1188..1224
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1226..1262
FT /note="EGF-like 2; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1264..1300
FT /note="EGF-like 3; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1302..1338
FT /note="EGF-like 4; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1340..1376
FT /note="EGF-like 5; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1378..1414
FT /note="EGF-like 6; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1419..1623
FT /note="Pentraxin (PTX)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT DOMAIN 1624..1682
FT /note="Sushi 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1683..1740
FT /note="Sushi 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1740..1779
FT /note="EGF-like 7; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1776..1839
FT /note="Sushi 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1840..1897
FT /note="Sushi 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1898..1955
FT /note="Sushi 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1956..2013
FT /note="Sushi 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2014..2075
FT /note="Sushi 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2076..2138
FT /note="Sushi 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2139..2196
FT /note="Sushi 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2197..2256
FT /note="Sushi 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2257..2315
FT /note="Sushi 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2316..2373
FT /note="Sushi 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2374..2432
FT /note="Sushi 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2433..2490
FT /note="Sushi 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2491..2548
FT /note="Sushi 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2549..2605
FT /note="Sushi 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2659..2708
FT /note="Sushi 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2709..2766
FT /note="Sushi 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2767..2824
FT /note="Sushi 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2825..2882
FT /note="Sushi 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2883..2940
FT /note="Sushi 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2941..2998
FT /note="Sushi 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2999..3054
FT /note="Sushi 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3055..3112
FT /note="Sushi 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3113..3171
FT /note="Sushi 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3172..3231
FT /note="Sushi 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3232..3289
FT /note="Sushi 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3290..3347
FT /note="Sushi 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3348..3406
FT /note="Sushi 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3407..3463
FT /note="Sushi 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3493..3525
FT /note="EGF-like 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 3526..3557
FT /note="EGF-like 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1760
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 379..421
FT /evidence="ECO:0000250"
FT DISULFID 407..434
FT /evidence="ECO:0000250"
FT DISULFID 439..481
FT /evidence="ECO:0000250"
FT DISULFID 467..494
FT /evidence="ECO:0000250"
FT DISULFID 499..544
FT /evidence="ECO:0000250"
FT DISULFID 530..559
FT /evidence="ECO:0000250"
FT DISULFID 727..769
FT /evidence="ECO:0000250"
FT DISULFID 753..787
FT /evidence="ECO:0000250"
FT DISULFID 1192..1203
FT /evidence="ECO:0000250"
FT DISULFID 1197..1212
FT /evidence="ECO:0000250"
FT DISULFID 1214..1223
FT /evidence="ECO:0000250"
FT DISULFID 1230..1241
FT /evidence="ECO:0000250"
FT DISULFID 1235..1250
FT /evidence="ECO:0000250"
FT DISULFID 1252..1261
FT /evidence="ECO:0000250"
FT DISULFID 1268..1279
FT /evidence="ECO:0000250"
FT DISULFID 1273..1288
FT /evidence="ECO:0000250"
FT DISULFID 1290..1299
FT /evidence="ECO:0000250"
FT DISULFID 1306..1317
FT /evidence="ECO:0000250"
FT DISULFID 1311..1326
FT /evidence="ECO:0000250"
FT DISULFID 1328..1337
FT /evidence="ECO:0000250"
FT DISULFID 1344..1355
FT /evidence="ECO:0000250"
FT DISULFID 1349..1364
FT /evidence="ECO:0000250"
FT DISULFID 1366..1375
FT /evidence="ECO:0000250"
FT DISULFID 1382..1393
FT /evidence="ECO:0000250"
FT DISULFID 1387..1402
FT /evidence="ECO:0000250"
FT DISULFID 1404..1413
FT /evidence="ECO:0000250"
FT DISULFID 1626..1667
FT /evidence="ECO:0000250"
FT DISULFID 1653..1680
FT /evidence="ECO:0000250"
FT DISULFID 1685..1725
FT /evidence="ECO:0000250"
FT DISULFID 1711..1738
FT /evidence="ECO:0000250"
FT DISULFID 1744..1756
FT /evidence="ECO:0000250"
FT DISULFID 1750..1765
FT /evidence="ECO:0000250"
FT DISULFID 1767..1778
FT /evidence="ECO:0000250"
FT DISULFID 1784..1824
FT /evidence="ECO:0000250"
FT DISULFID 1810..1837
FT /evidence="ECO:0000250"
FT DISULFID 1842..1882
FT /evidence="ECO:0000250"
FT DISULFID 1868..1895
FT /evidence="ECO:0000250"
FT DISULFID 1900..1940
FT /evidence="ECO:0000250"
FT DISULFID 1926..1953
FT /evidence="ECO:0000250"
FT DISULFID 1958..1998
FT /evidence="ECO:0000250"
FT DISULFID 1984..2011
FT /evidence="ECO:0000250"
FT DISULFID 2016..2056
FT /evidence="ECO:0000250"
FT DISULFID 2042..2073
FT /evidence="ECO:0000250"
FT DISULFID 2078..2121
FT /evidence="ECO:0000250"
FT DISULFID 2107..2136
FT /evidence="ECO:0000250"
FT DISULFID 2141..2181
FT /evidence="ECO:0000250"
FT DISULFID 2167..2194
FT /evidence="ECO:0000250"
FT DISULFID 2199..2240
FT /evidence="ECO:0000250"
FT DISULFID 2226..2254
FT /evidence="ECO:0000250"
FT DISULFID 2259..2299
FT /evidence="ECO:0000250"
FT DISULFID 2285..2313
FT /evidence="ECO:0000250"
FT DISULFID 2318..2358
FT /evidence="ECO:0000250"
FT DISULFID 2344..2371
FT /evidence="ECO:0000250"
FT DISULFID 2376..2417
FT /evidence="ECO:0000250"
FT DISULFID 2403..2430
FT /evidence="ECO:0000250"
FT DISULFID 2435..2475
FT /evidence="ECO:0000250"
FT DISULFID 2461..2488
FT /evidence="ECO:0000250"
FT DISULFID 2493..2533
FT /evidence="ECO:0000250"
FT DISULFID 2519..2546
FT /evidence="ECO:0000250"
FT DISULFID 2551..2591
FT /evidence="ECO:0000250"
FT DISULFID 2577..2603
FT /evidence="ECO:0000250"
FT DISULFID 2679..2706
FT /evidence="ECO:0000250"
FT DISULFID 2711..2751
FT /evidence="ECO:0000250"
FT DISULFID 2737..2764
FT /evidence="ECO:0000250"
FT DISULFID 2769..2809
FT /evidence="ECO:0000250"
FT DISULFID 2795..2822
FT /evidence="ECO:0000250"
FT DISULFID 2827..2867
FT /evidence="ECO:0000250"
FT DISULFID 2853..2880
FT /evidence="ECO:0000250"
FT DISULFID 2885..2925
FT /evidence="ECO:0000250"
FT DISULFID 2911..2938
FT /evidence="ECO:0000250"
FT DISULFID 2943..2983
FT /evidence="ECO:0000250"
FT DISULFID 2969..2996
FT /evidence="ECO:0000250"
FT DISULFID 3001..3040
FT /evidence="ECO:0000250"
FT DISULFID 3026..3052
FT /evidence="ECO:0000250"
FT DISULFID 3057..3097
FT /evidence="ECO:0000250"
FT DISULFID 3083..3110
FT /evidence="ECO:0000250"
FT DISULFID 3115..3156
FT /evidence="ECO:0000250"
FT DISULFID 3141..3169
FT /evidence="ECO:0000250"
FT DISULFID 3174..3214
FT /evidence="ECO:0000250"
FT DISULFID 3200..3229
FT /evidence="ECO:0000250"
FT DISULFID 3234..3274
FT /evidence="ECO:0000250"
FT DISULFID 3260..3287
FT /evidence="ECO:0000250"
FT DISULFID 3292..3332
FT /evidence="ECO:0000250"
FT DISULFID 3318..3345
FT /evidence="ECO:0000250"
FT DISULFID 3350..3391
FT /evidence="ECO:0000250"
FT DISULFID 3377..3404
FT /evidence="ECO:0000250"
FT DISULFID 3409..3449
FT /evidence="ECO:0000250"
FT DISULFID 3435..3461
FT /evidence="ECO:0000250"
FT DISULFID 3497..3507
FT /evidence="ECO:0000250"
FT DISULFID 3501..3513
FT /evidence="ECO:0000250"
FT DISULFID 3515..3524
FT /evidence="ECO:0000250"
FT DISULFID 3529..3539
FT /evidence="ECO:0000250"
FT DISULFID 3533..3545
FT /evidence="ECO:0000250"
FT DISULFID 3547..3556
FT /evidence="ECO:0000250"
SQ SEQUENCE 3564 AA; 387355 MW; BA1A3F013BEE2A31 CRC64;
MWTRLAFCCW ALALVSGWTN FQPMAPSLNF SFRLFPEASP GALGRLAVPP RSGEEEAVGS
KVERLGRTFR SRVRRLRELS DRLELVFLVD ESSSVGQTNF LNELKFVRKL LSDFPVVSTA
TRVAIVTFSS KNNVVARVDY ISTSRAHQHK CALLSREIPA ITYRGGGTYT MGAFQQAAQI
LRHSRENSTK VIFLITDGYS NGGDPRPIAA SLRDFGVEIF TFGIWQGNIR ELNDMASTPK
EEHCYLLHSF EEFEALARRA LHEDLPSGSF IQEDMAHCSY LCEAGRDCCD RMASCKCGTH
TGQFECICEK GYYGKGLQYE CTACPPGTYK PEASPGGIST CIPCPDENHT SPPGSTAPED
CVCREGYQRS GQTCEVVHCP ALKPPENGFF IQNTCKNHFN AACGVRCRPG FDLVGSSIHL
CQPNGLWSGT ESFCRVRTCP HLRQPKHGHI SCSTVEMSYN TVCLVTCNEG YRLEGHAKLT
CQGNAQWDGT EPRCVERHCA TFQKPKGVII SPPSCGKQPA KPGMICQLGC RQGYILSGIR
EVRCATSGKW SARVQTAVCK DVEAPQISCP NDIKAKTEGQ QDSANVTWQV PTAKDNSGEK
VSVHVHPAFS PPYLFPIGEV AITYTATDSS GNQASCTFYI KVIDVEPPVI DWCRSPPPIQ
VVEKEHPASW DEPQFSDNSG AELVITSSHT QGDLFPHGET VVWYTATDPS GNNRTCDIHI
VIKGSPCEVP FTPVNGDFIC AQDSAGVNCS LTCREGYDFT EGSTEKYYCA FEDGIWRPPY
STEWPDCAIK RFANHGFKSF EMLYKTTRCD DMDLFKKFSA AFETTLGKMV PSFCSDADDI
DCRLEDLTKK YCIEYNYNYE NGFAIGPGGW GAGNRLDYSY DHFLDVVQET PADVGKTRSS
RIKRTVPLSD PQIQLIFNIT ASVPLPEERN DTVELENQQR LIRTLETITN RLKSTLNKGP
MYSFQLASET VVADSNSLET EKAFLFCRPG SVLRGRMCVN CPLGTSYSLE HSTCESCLMG
SYQDEEGQLE CKLCPPRTHT EYLHSRSISE CKAQCKQGTY SSSGLETCES CPLGTYQPDF
GSRSCLPCPE TTTTVKRGAV DISACGVPCP VGEFSRSGLT PCYPCPRDYY QPNAGKSFCL
ACPFYGTTTI TGATSITDCS SFSSTFSAAE ESIVPLAAPG PTQNKYEVFH ECFLNPCHNS
GTCQQLGRGY VCLCPPGYTG LKCETDIDEC SSLPCLNGGI CRDKVGGFTC ECSSGYTGQI
CEENINECSS SPCLNKGTCT DGLASYRCTC VSGYVGVHCE TDVNECQSSP CLNNAVCKDQ
VGGFSCKCPP GFLGTRCEKN VDECLSQPCQ NGATCKDGAN SFRCQCPAGF TGPHCELNIN
ECQSNPCRNQ ATCVDELNSY SCKCRPGFSG RRCETEQPSG FNLDFEVSGI YGYVLLDGVL
PTLHAITCAF WMKSSDVINY GTPISYALEG NKDNTFLLTD YNGWVLYVNG KEKITNCPSV
NDGIWHHIAI TWTSTGGAWR VYIDGELSDS GTGLSVGKAI PGGGALVLGQ EQDKKGEGFN
PAESFVGSIS QLNLWDYVLS PQQVKSLASS CPEELSRGNV LAWPDFVSGI TGKVKVDSSS
IFCSDCPSLE GSVPHLRPAS GDRKPGSKVS LFCDPGFQMV GNPVQYCLNQ GQWSQPLPHC
ERIRCGLPPT LENGFYSAED LHAGSTVTYQ CTSGYYLLGD SRMFCTDNGS WNGISPSCLD
VDECAVGSDC SEHASCLNTN GSYICSCKPP YTGDGKNCAE PVKCKAPENP ENGHSLGKIY
SVGAEVTFSC EEGHQLVGVR KITCLESGEW DHLRPSCEAI SCGAPPVPEN GGVDGSAFTY
GSKVRYRCDK GYTLAGDEES ACLASGSWSH SSPVCELVKC SQPENINNGK YILSGLTYLS
IASYSCEDGY SLQGPSLIEC TASGSWDRAP PSCQLVSCGE PPMVKDALTT GSNFTFGNMV
TYTCKEGYTL AGPDTIICQA NGKWNSSNHQ CLAVSCDEPP NVDHASPETA HRLFGDTAFY
YCADGYSLAD NSQLICNAQG NWVPPEGQAV PRCIAHFCEK PPSVSYSILE SVSKAKFAAG
SVVSFKCMEG FVLNTSAKIE CLRGGQWSPS PLSVQCIPVR CGEPPSITNG YPSGTNYSFG
AVVAYSCHKG FYIKGEKKST CEATGQWSRP LPTCHPVSCN EPPKVENGFL EHTTGRTFES
EARFQCNPGY KAVGSPVFVC QANRHWHSDA PLSCTPLNCG KPPPIQNGFL RGESFEVGSK
VQFVCNEGYE LVGDNSWTCQ KSGKWSKKPS PKCVPTKCAE PPLLENQLVL KELTSEVGVM
TISCKEGHAL QGPSVLKCLP SGQWNGSFPV CKLVLCQSPP LIPFGVPASS GALHFGSTVK
YLCVDGFFLR GNPIILCQVD GTWSSPLPEC VPVECPQPEE ILNGIIHVQG LAYLSTTLYT
CKPGFELVGN TTTLCGENGQ WLGGKPMCRP IECPEPKEIL NGQFSSVSFQ YGQTITYSCD
RGFRLEGPKS LTCLETGNWD MDAPSCNAIH CSDPQPIENG FVEGADYRYG AMIIYSCFPG
FQVVGHAMQT CEETGWSSSS PTCVPIDCGL PPHIDFGDCT RVSDGQGYFV QEDDMMEVPY
LTPHPQHLEA TAKASEITEE SLVPHASQFL YGTTVSYRCE PGYELLGIPV LVCQEDGTWN
GTAPSCISIE CDLPVAPENG FLHFTQTTMG SAAQYSCKPG HVLEGSHLRL CLQNKQWSGT
VPRCEVISCS EPNPLGNGSI KGNDYSYLGV LHYECDSGYV LNGTEKRTCQ ENKQWDGHEP
VCLPVDCGSP PVPTNGQVTG EEYTFQKEIA YSCGEGFILE GARSRVCLTN GSWSGTTPSC
VPVRCPAPPQ VANGVTDGLD YGFKKEVTFH CLEGYVLQGT PKLTCQSNGT WDAEVPICKP
ATCGPPADLP QGFPNGFSFF HGGHIQYQCF TGYKLHGNPS RRCLPDGSWS GSTPSCLPCT
CSTPIIQQGT VNATDLGCGK TVQIECFKGF KLLGLPEITC DANGQWSDFP LCEHADCGPL
PTVPNGIVIK GSPSEDNVVT YSCRPGYIIQ GSSDLICTEK GIWSEPYPTC EPVSCGPPPT
VANAVATGEA HTYESKVKLR CLEGYVVDTD TDTFTCQQDG RWFPERINCS PKTCPVPSNR
TRIRVHGDDF QVNRQVSVSC TEGFTYDGAD RSTCQPDGTW EPPLSEESCI PVVCGQPESP
EHGFVVGSEY SFGSTVVYQC DPGYELEGNR ERVCQENRQW SGRVAVCRES RCEAPAEFPN
GKAVLENTTS GPSLLFSCHR GYTLEGPPEA HCTANGTWSH LAPLCKPNPC PVPFVIPENA
LLSEREFYVN QNVSIKCREG FLLKGNGIIT CNPDETWTQT NARCEKISCG PPTHVENAIA
RGVHYQYGDM VTFSCYSGYM LEGSLRSVCL ENGTWTPPPI CRAVCRFPCQ NGGVCQRPNA
CSCPDGWMGR LCEEPICILP CLNGGRCVAP YRCDCPAGWT GSRCHTATCQ SPCLNGGKCV
RPNRCHCLSS WTGHDCSRKR RSGL
