SVF1_YEAST
ID SVF1_YEAST Reviewed; 481 AA.
AC Q05515; D6VSX6;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Survival factor 1;
GN Name=SVF1; Synonyms=SGI1; OrderedLocusNames=YDR346C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION.
RX PubMed=12244097; DOI=10.1074/jbc.m204888200;
RA Vander Heiden M.G., Choy J.S., VanderWeele D.J., Brace J.L., Harris M.H.,
RA Bauer D.E., Prange B., Kron S.J., Thompson C.B., Rudin C.M.;
RT "Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the
RT switch from glycolytic to oxidative metabolism.";
RL J. Biol. Chem. 277:44870-44876(2002).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP FUNCTION.
RX PubMed=16034825; DOI=10.1002/yea.1235;
RA Brace J.L., Vanderweele D.J., Rudin C.M.;
RT "Svf1 inhibits reactive oxygen species generation and promotes survival
RT under conditions of oxidative stress in Saccharomyces cerevisiae.";
RL Yeast 22:641-652(2005).
CC -!- FUNCTION: Required for survival in response to oxidative stress.
CC Involved in the diauxic shift. {ECO:0000269|PubMed:12244097,
CC ECO:0000269|PubMed:16034825}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 45200 molecules/cell in log phase SD
CC medium. {ECO:0000269|PubMed:14562106}.
CC -!- MISCELLANEOUS: Expression in mammalian cells increases survival under
CC conditions inducing apoptosis.
CC -!- SIMILARITY: Belongs to the SVF1 family. {ECO:0000305}.
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DR EMBL; U51032; AAB64782.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA12186.1; -; Genomic_DNA.
DR PIR; S70111; S70111.
DR RefSeq; NP_010633.3; NM_001180654.3.
DR AlphaFoldDB; Q05515; -.
DR BioGRID; 32402; 97.
DR DIP; DIP-5243N; -.
DR IntAct; Q05515; 14.
DR MINT; Q05515; -.
DR STRING; 4932.YDR346C; -.
DR iPTMnet; Q05515; -.
DR MaxQB; Q05515; -.
DR PaxDb; Q05515; -.
DR PRIDE; Q05515; -.
DR EnsemblFungi; YDR346C_mRNA; YDR346C; YDR346C.
DR GeneID; 851947; -.
DR KEGG; sce:YDR346C; -.
DR SGD; S000002754; SVF1.
DR VEuPathDB; FungiDB:YDR346C; -.
DR eggNOG; ENOG502QQY3; Eukaryota.
DR GeneTree; ENSGT00990000203553; -.
DR HOGENOM; CLU_030205_3_1_1; -.
DR InParanoid; Q05515; -.
DR OMA; AFWPRCV; -.
DR BioCyc; YEAST:G3O-29900-MON; -.
DR PRO; PR:Q05515; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q05515; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0034599; P:cellular response to oxidative stress; IMP:SGD.
DR InterPro; IPR033394; Svf1-like_C.
DR InterPro; IPR013931; Svf1-like_N.
DR Pfam; PF08622; Svf1; 1.
DR Pfam; PF17187; Svf1_C; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..481
FT /note="Survival factor 1"
FT /id="PRO_0000072336"
FT REGION 197..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..243
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..389
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 481 AA; 54368 MW; 926A28FE140F87A5 CRC64;
MLKWIKGGIS AVTGMAEPEY GKDYIHSVAD RVKNKQPYRE TSREDFFWQA PDHTNVESVI
FYFSDLKTGI FGFAQVIHSN IIGLHTASQF TFRIFDSKNP EDLNIWTSTK LENFYIEGPN
FYADNLSVEL SEDGESYHIQ SSVCDLSVVD LHIRRLTPGA KIGDDPATYY GNNINEPWGS
MRHVFWPRNA CHGTIKVKKE VIPESDEEES SADEDDNEDE DEESGDSEEE SGSEEESDSE
EVEITYEDRT ITFKEEDPAI STFIMAFQGM KPHHAAKAWN FMFFHSEKYS AVLMEFTTPK
SYANTKISAG IITDDKEVLA MTTNNLVEHL NSEIDSVGWK VPKDIKITFK GINTKVKDEQ
LESENGTEQA LQGEDEKEDE KEDEEEEEYK NVAEENKICA VVEGPLNNLV ERIDVMGEIP
SFVKNIVSGV AGTKPFIYQY ADPKSSTLQI NGGEKIHGVA WTEVTFISES DVISEESYNE
A
