SVH11_CAEEL
ID SVH11_CAEEL Reviewed; 364 AA.
AC Q966A0; A0A0M7RER3;
DT 17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Putative galactoside 2-alpha-L-fucosyltransferase svh-11 {ECO:0000303|PubMed:31371405};
DE EC=2.4.1.- {ECO:0000305|PubMed:31371405};
DE AltName: Full=Suppressor of vhp-1 deletion lethality protein svh-11 {ECO:0000312|WormBase:Y5H2B.1a};
GN Name=svh-11 {ECO:0000312|WormBase:Y5H2B.1a};
GN ORFNames=Y5H2B.1 {ECO:0000312|WormBase:Y5H2B.1a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION.
RX PubMed=31371405; DOI=10.1534/genetics.119.302492;
RA Shimizu T., Kato Y., Sakai Y., Hisamoto N., Matsumoto K.;
RT "N-Glycosylation of the Discoidin Domain Receptor Is Required for Axon
RT Regeneration in Caenorhabditis elegans.";
RL Genetics 213:491-500(2019).
CC -!- FUNCTION: Mediates the transfer of fucose to the terminal galactose on
CC glycan chains of cell surface glycoproteins and glycolipids (By
CC similarity). Required for axon regeneration after injury
CC (PubMed:31371405). {ECO:0000250|UniProtKB:Q10981,
CC ECO:0000269|PubMed:31371405}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane
CC {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:Y5H2B.1a};
CC IsoId=Q966A0-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:Y5H2B.1b};
CC IsoId=Q966A0-2; Sequence=VSP_060577;
CC -!- SIMILARITY: Belongs to the glycosyltransferase 11 family.
CC {ECO:0000305}.
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DR EMBL; BX284605; CCD67431.1; -; Genomic_DNA.
DR EMBL; BX284605; CUR30074.1; -; Genomic_DNA.
DR RefSeq; NP_001303775.1; NM_001316846.1. [Q966A0-2]
DR RefSeq; NP_503601.1; NM_071200.1. [Q966A0-1]
DR AlphaFoldDB; Q966A0; -.
DR STRING; 6239.Y5H2B.1; -.
DR CAZy; GT11; Glycosyltransferase Family 11.
DR PaxDb; Q966A0; -.
DR EnsemblMetazoa; Y5H2B.1a.1; Y5H2B.1a.1; WBGene00021164. [Q966A0-1]
DR EnsemblMetazoa; Y5H2B.1b.1; Y5H2B.1b.1; WBGene00021164. [Q966A0-2]
DR GeneID; 189361; -.
DR KEGG; cel:CELE_Y5H2B.1; -.
DR UCSC; Y5H2B.1; c. elegans. [Q966A0-1]
DR CTD; 189361; -.
DR WormBase; Y5H2B.1a; CE26220; WBGene00021164; svh-11. [Q966A0-1]
DR WormBase; Y5H2B.1b; CE51117; WBGene00021164; svh-11.
DR eggNOG; ENOG502SVMQ; Eukaryota.
DR GeneTree; ENSGT00530000064380; -.
DR HOGENOM; CLU_038305_0_0_1; -.
DR InParanoid; Q966A0; -.
DR OMA; MTHENEQ; -.
DR OrthoDB; 1006406at2759; -.
DR PhylomeDB; Q966A0; -.
DR PRO; PR:Q966A0; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00021164; Expressed in anatomical system and 2 other tissues.
DR ExpressionAtlas; Q966A0; baseline.
DR GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008107; F:galactoside 2-alpha-L-fucosyltransferase activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0043413; P:macromolecule glycosylation; IBA:GO_Central.
DR GO; GO:0048680; P:positive regulation of axon regeneration; IMP:UniProtKB.
DR InterPro; IPR002516; Glyco_trans_11.
DR Pfam; PF01531; Glyco_transf_11; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Glycoprotein; Glycosyltransferase; Golgi apparatus;
KW Membrane; Reference proteome; Signal-anchor; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..364
FT /note="Putative galactoside 2-alpha-L-fucosyltransferase
FT svh-11"
FT /id="PRO_0000449893"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 20..42
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..364
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT VAR_SEQ 302..364
FT /note="APRSTFGWWIGYFSKGNKVYYLDIKYTGDHIFESGGLIASDFYPSHWTPLKF
FT ASANSFTVVRS -> ETPKFQLPAQHSAGGLGIFRKETKFTIWILNTLGIIFLNLEVLL
FT QVTSTHHTGRL (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_060577"
SQ SEQUENCE 364 AA; 42570 MW; B46823DE00E48440 CRC64;
MRLFHFLKFL TINNFSRYCL KIVKVHIIWI TIICIIYFNW RFKKLDFMAI PYPPAVIKFN
TSAKYLSSNL ASSSQLGNNI FEIASLYGLS KHLNRTPLFF IENGYHKKML DNLRKTMPRL
MEKFRILNGS VPRSISETKF QRACCLHKSP WSLEKNRDEY LHLSGKYYQS WKYFPNMRNE
LIEFLNPTSI QIFGNLPISD DQNHVTCVHS RRGDFVEYLF YASDPKFMKN AVTFLNENEK
VGSRNRKIVL FGDDLNFLET YFSDAVLSTD VGKNAEYYIS QNPPIDDFLY SKNNCDVVLI
TAPRSTFGWW IGYFSKGNKV YYLDIKYTGD HIFESGGLIA SDFYPSHWTP LKFASANSFT
VVRS
