SVIP_HUMAN
ID SVIP_HUMAN Reviewed; 77 AA.
AC Q8NHG7;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Small VCP/p97-interacting protein;
GN Name=SVIP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RA Guo J.H., Yu L.;
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP INTERACTION WITH VCP, AND VIM MOTIF.
RX PubMed=21896481; DOI=10.1074/jbc.m111.274472;
RA Stapf C., Cartwright E., Bycroft M., Hofmann K., Buchberger A.;
RT "The general definition of the p97/valosin-containing protein (VCP)-
RT interacting motif (VIM) delineates a new family of p97 cofactors.";
RL J. Biol. Chem. 286:38670-38678(2011).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [4]
RP MYRISTOYLATION AT GLY-2, CLEAVAGE OF INITIATOR METHIONINE, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=25255805; DOI=10.1038/ncomms5919;
RA Thinon E., Serwa R.A., Broncel M., Brannigan J.A., Brassat U., Wright M.H.,
RA Heal W.P., Wilkinson A.J., Mann D.J., Tate E.W.;
RT "Global profiling of co- and post-translationally N-myristoylated proteomes
RT in human cells.";
RL Nat. Commun. 5:4919-4919(2014).
CC -!- SUBUNIT: Interacts (via VIM motif) with VCP.
CC {ECO:0000269|PubMed:21896481}.
CC -!- INTERACTION:
CC Q8NHG7; Q9BZV1: UBXN6; NbExp=3; IntAct=EBI-2513231, EBI-1993899;
CC -!- SUBCELLULAR LOCATION: Smooth endoplasmic reticulum membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi
CC apparatus membrane {ECO:0000250}; Peripheral membrane protein
CC {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein
CC {ECO:0000250}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SVIP family. {ECO:0000305}.
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DR EMBL; AF527534; AAM88869.1; -; mRNA.
DR CCDS; CCDS41627.1; -.
DR RefSeq; NP_001307269.1; NM_001320340.1.
DR RefSeq; NP_001307271.1; NM_001320342.1.
DR RefSeq; NP_683691.1; NM_148893.2.
DR AlphaFoldDB; Q8NHG7; -.
DR BMRB; Q8NHG7; -.
DR SMR; Q8NHG7; -.
DR BioGRID; 129222; 24.
DR CORUM; Q8NHG7; -.
DR IntAct; Q8NHG7; 12.
DR MINT; Q8NHG7; -.
DR STRING; 9606.ENSP00000346130; -.
DR GlyGen; Q8NHG7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8NHG7; -.
DR PhosphoSitePlus; Q8NHG7; -.
DR SwissPalm; Q8NHG7; -.
DR BioMuta; SVIP; -.
DR EPD; Q8NHG7; -.
DR jPOST; Q8NHG7; -.
DR MassIVE; Q8NHG7; -.
DR MaxQB; Q8NHG7; -.
DR PaxDb; Q8NHG7; -.
DR PeptideAtlas; Q8NHG7; -.
DR PRIDE; Q8NHG7; -.
DR ProteomicsDB; 73706; -.
DR Antibodypedia; 48732; 8 antibodies from 7 providers.
DR DNASU; 258010; -.
DR Ensembl; ENST00000354193.5; ENSP00000346130.4; ENSG00000198168.9.
DR GeneID; 258010; -.
DR KEGG; hsa:258010; -.
DR MANE-Select; ENST00000354193.5; ENSP00000346130.4; NM_148893.3; NP_683691.1.
DR UCSC; uc001mqp.5; human.
DR CTD; 258010; -.
DR DisGeNET; 258010; -.
DR GeneCards; SVIP; -.
DR HGNC; HGNC:25238; SVIP.
DR HPA; ENSG00000198168; Low tissue specificity.
DR neXtProt; NX_Q8NHG7; -.
DR OpenTargets; ENSG00000198168; -.
DR PharmGKB; PA164726394; -.
DR VEuPathDB; HostDB:ENSG00000198168; -.
DR eggNOG; ENOG502S5MU; Eukaryota.
DR GeneTree; ENSGT00390000007067; -.
DR HOGENOM; CLU_174267_1_0_1; -.
DR InParanoid; Q8NHG7; -.
DR OMA; CCGQSAE; -.
DR PhylomeDB; Q8NHG7; -.
DR PathwayCommons; Q8NHG7; -.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR SignaLink; Q8NHG7; -.
DR SIGNOR; Q8NHG7; -.
DR BioGRID-ORCS; 258010; 18 hits in 1062 CRISPR screens.
DR ChiTaRS; SVIP; human.
DR GenomeRNAi; 258010; -.
DR Pharos; Q8NHG7; Tbio.
DR PRO; PR:Q8NHG7; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NHG7; protein.
DR Bgee; ENSG00000198168; Expressed in C1 segment of cervical spinal cord and 184 other tissues.
DR Genevisible; Q8NHG7; HS.
DR GO; GO:0031225; C:anchored component of membrane; IDA:ParkinsonsUK-UCL.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0030667; C:secretory granule membrane; TAS:Reactome.
DR GO; GO:0030868; C:smooth endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070821; C:tertiary granule membrane; TAS:Reactome.
DR GO; GO:0051117; F:ATPase binding; IPI:ParkinsonsUK-UCL.
DR GO; GO:0043621; F:protein self-association; IMP:UniProtKB.
DR GO; GO:1903070; P:negative regulation of ER-associated ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
DR GO; GO:0031333; P:negative regulation of protein-containing complex assembly; IMP:UniProtKB.
DR GO; GO:1904153; P:negative regulation of retrograde protein transport, ER to cytosol; IMP:ParkinsonsUK-UCL.
DR GO; GO:1904240; P:negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly; IBA:GO_Central.
DR GO; GO:0010508; P:positive regulation of autophagy; IMP:UniProtKB.
DR GO; GO:1903061; P:positive regulation of protein lipidation; IMP:UniProtKB.
DR InterPro; IPR031632; SVIP.
DR PANTHER; PTHR35269; PTHR35269; 1.
DR Pfam; PF15811; SVIP; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Endoplasmic reticulum; Golgi apparatus; Lipoprotein;
KW Membrane; Myristate; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:25255805"
FT CHAIN 2..77
FT /note="Small VCP/p97-interacting protein"
FT /id="PRO_0000072337"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 21..33
FT /note="VCP/p97-interacting motif (VIM)"
FT /evidence="ECO:0000269|PubMed:21896481"
FT REGION 25..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 46
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000269|PubMed:25255805"
SQ SEQUENCE 77 AA; 8443 MW; 09744BB0437F44BC CRC64;
MGLCFPCPGE SAPPTPDLEE KRAKLAEAAE RRQKEAASRG ILDVQSVQEK RKKKEKIEKQ
IATSGPPPEG GLRWTVS
