SVIP_MOUSE
ID SVIP_MOUSE Reviewed; 77 AA.
AC Q3UZP4;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Small VCP/p97-interacting protein;
GN Name=Svip;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBUNIT: Interacts with VCP. {ECO:0000250|UniProtKB:Q8NHG7}.
CC -!- SUBCELLULAR LOCATION: Smooth endoplasmic reticulum membrane; Peripheral
CC membrane protein. Golgi apparatus membrane; Peripheral membrane
CC protein. Cell membrane {ECO:0000250}; Peripheral membrane protein
CC {ECO:0000250}. Membrane {ECO:0000250|UniProtKB:Q8NHG7}; Lipid-anchor
CC {ECO:0000250|UniProtKB:Q8NHG7}.
CC -!- SIMILARITY: Belongs to the SVIP family. {ECO:0000305}.
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DR EMBL; AK133737; BAE21812.1; -; mRNA.
DR CCDS; CCDS57551.1; -.
DR RefSeq; NP_001153817.1; NM_001160345.1.
DR AlphaFoldDB; Q3UZP4; -.
DR SMR; Q3UZP4; -.
DR BioGRID; 217708; 1.
DR STRING; 10090.ENSMUSP00000096014; -.
DR iPTMnet; Q3UZP4; -.
DR PhosphoSitePlus; Q3UZP4; -.
DR MaxQB; Q3UZP4; -.
DR PaxDb; Q3UZP4; -.
DR PeptideAtlas; Q3UZP4; -.
DR PRIDE; Q3UZP4; -.
DR ProteomicsDB; 254724; -.
DR Antibodypedia; 48732; 8 antibodies from 7 providers.
DR Ensembl; ENSMUST00000098414; ENSMUSP00000096014; ENSMUSG00000074093.
DR GeneID; 75744; -.
DR KEGG; mmu:75744; -.
DR UCSC; uc009hcn.2; mouse.
DR CTD; 258010; -.
DR MGI; MGI:1922994; Svip.
DR VEuPathDB; HostDB:ENSMUSG00000074093; -.
DR eggNOG; ENOG502S5MU; Eukaryota.
DR GeneTree; ENSGT00390000007067; -.
DR HOGENOM; CLU_174267_1_0_1; -.
DR InParanoid; Q3UZP4; -.
DR OMA; CCGQSAE; -.
DR OrthoDB; 1513733at2759; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 75744; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Svip; mouse.
DR PRO; PR:Q3UZP4; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3UZP4; protein.
DR Bgee; ENSMUSG00000074093; Expressed in seminiferous tubule of testis and 215 other tissues.
DR ExpressionAtlas; Q3UZP4; baseline and differential.
DR Genevisible; Q3UZP4; MM.
DR GO; GO:0031225; C:anchored component of membrane; ISO:MGI.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030868; C:smooth endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051117; F:ATPase binding; ISO:MGI.
DR GO; GO:0043621; F:protein self-association; ISO:MGI.
DR GO; GO:1903070; P:negative regulation of ER-associated ubiquitin-dependent protein catabolic process; ISO:MGI.
DR GO; GO:0031333; P:negative regulation of protein-containing complex assembly; ISO:MGI.
DR GO; GO:1904153; P:negative regulation of retrograde protein transport, ER to cytosol; ISO:MGI.
DR GO; GO:1904240; P:negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly; ISO:MGI.
DR GO; GO:0010508; P:positive regulation of autophagy; ISO:MGI.
DR GO; GO:1903061; P:positive regulation of protein lipidation; ISO:MGI.
DR InterPro; IPR031632; SVIP.
DR PANTHER; PTHR35269; PTHR35269; 1.
DR Pfam; PF15811; SVIP; 1.
PE 3: Inferred from homology;
KW Cell membrane; Endoplasmic reticulum; Golgi apparatus; Lipoprotein;
KW Membrane; Myristate; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q8NHG7"
FT CHAIN 2..77
FT /note="Small VCP/p97-interacting protein"
FT /id="PRO_0000280799"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 21..33
FT /note="VCP/p97-interacting motif (VIM)"
FT /evidence="ECO:0000250|UniProtKB:Q8NHG7"
FT COMPBIAS 16..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 46
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8NHG7"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000250|UniProtKB:Q8NHG7"
SQ SEQUENCE 77 AA; 8364 MW; DB4E4416563E979E CRC64;
MGLCFPCPAE SAPPSPSPEE KREKLAEAAE RRQKEAATRG ILDIQSVEAK KKKKEQLEKQ
MATSGPPTAG GLRWTVS
