ID   SVMI2_ATHNI             Reviewed;          30 AA.
AC   P0C7K6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Poly-His-poly-Gly peptide 2;
DE            Short=pHpG 2;
OS   Atheris nitschei (Great lakes bush viper).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Viperinae; Atheris.
OX   NCBI_TaxID=110224;
RN   [1]
RP   PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=17206746; DOI=10.1002/rcm.2853;
RA   Favreau P., Cheneval O., Menin L., Michalet S., Gaertner H., Principaud F.,
RA   Thai R., Menez A., Bulet P., Stoecklin R.;
RT   "The venom of the snake genus Atheris contains a new class of peptides with
RT   clusters of histidine and glycine residues.";
RL   Rapid Commun. Mass Spectrom. 21:406-412(2007).
CC   -!- FUNCTION: May serve as a metalloproteinase inhibitor during glandular
CC       storage. Their inhibition may be instantly disengaged, by dilution or
CC       physiochemical change, when venom is injected into tissue of the
CC       victim. {ECO:0000250|UniProtKB:A8YPR6}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MASS SPECTROMETRY: Mass=3071.39; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:17206746};
CC   -!- SIMILARITY: Belongs to the pHpG family. {ECO:0000305}.
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DR   AlphaFoldDB; P0C7K6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Metalloenzyme inhibitor;
KW   Metalloprotease inhibitor; Protease inhibitor; Secreted.
FT   PEPTIDE         1..30
FT                   /note="Poly-His-poly-Gly peptide 2"
FT                   /id="PRO_0000335994"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   30 AA;  3073 MW;  9EE78B9E9246E4A1 CRC64;
     EDDHDHHHHH HHHHHHHGVG GGGGGGGGGA