ID   SVMI_BOTFO              Reviewed;          18 AA.
AC   P0DL08;
DT   03-APR-2013, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2013, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Poly-His-poly-Gly peptide 1;
DE            Short=pHpG-1;
OS   Bothrops fonsecai (Fonseca's lancehead) (Rhinocerophis fonsecai).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
OX   NCBI_TaxID=157549;
RN   [1]
RP   PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=22869554; DOI=10.1074/mcp.m112.019331;
RA   Tashima A.K., Zelanis A., Kitano E.S., Ianzer D., Melo R.L., Rioli V.,
RA   Sant'anna S.S., Schenberg A.C., Camargo A.C., Serrano S.M.T.;
RT   "Peptidomics of three Bothrops snake venoms: insights into the molecular
RT   diversification of proteomes and peptidomes.";
RL   Mol. Cell. Proteomics 11:1245-1262(2012).
CC   -!- FUNCTION: May serve as a metalloproteinase inhibitor during glandular
CC       storage. Their inhibition may be instantly disengaged, by dilution or
CC       physiochemical change, when venom is injected into tissue of the
CC       victim. {ECO:0000250|UniProtKB:A8YPR6}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MASS SPECTROMETRY: Mass=1506.6; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:22869554};
CC   -!- MISCELLANEOUS: Poly-His-poly-Gly peptide are encoded by two gene
CC       families: snake venom metalloprotease inhibitors and bradykinin-
CC       potentiating-C-type natriuretic peptides (BPP-CNP).
CC   -!- SIMILARITY: Belongs to the pHpG family. {ECO:0000305}.
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DR   AlphaFoldDB; P0DL08; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..18
FT                   /note="Poly-His-poly-Gly peptide 1"
FT                   /id="PRO_0000421922"
SQ   SEQUENCE   18 AA;  1508 MW;  28AB26262D264B44 CRC64;
     HHDHHAAVGG GGGGGGGA