SVOPL_HUMAN
ID SVOPL_HUMAN Reviewed; 492 AA.
AC Q8N434;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Putative transporter SVOPL;
DE AltName: Full=SV2-related protein-like;
DE AltName: Full=SVOP-like protein;
GN Name=SVOPL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=17714910; DOI=10.1016/j.ygeno.2007.03.017;
RA Jacobsson J.A., Haitina T., Lindblom J., Fredriksson R.;
RT "Identification of six putative human transporters with structural
RT similarity to the drug transporter SLC22 family.";
RL Genomics 90:595-609(2007).
CC -!- INTERACTION:
CC Q8N434-2; Q69YG0: TMEM42; NbExp=3; IntAct=EBI-23750686, EBI-12038591;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N434-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N434-2; Sequence=VSP_026651, VSP_026652;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; AC013429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC020983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC036796; AAH36796.1; -; mRNA.
DR CCDS; CCDS47721.1; -. [Q8N434-1]
DR CCDS; CCDS5848.1; -. [Q8N434-2]
DR RefSeq; NP_001132928.1; NM_001139456.1. [Q8N434-1]
DR RefSeq; NP_777619.1; NM_174959.3. [Q8N434-2]
DR RefSeq; XP_005250200.1; XM_005250143.3.
DR RefSeq; XP_011514099.1; XM_011515797.2. [Q8N434-2]
DR RefSeq; XP_016867236.1; XM_017011747.1. [Q8N434-2]
DR RefSeq; XP_016867237.1; XM_017011748.1. [Q8N434-2]
DR AlphaFoldDB; Q8N434; -.
DR SMR; Q8N434; -.
DR BioGRID; 126453; 10.
DR IntAct; Q8N434; 2.
DR STRING; 9606.ENSP00000405482; -.
DR TCDB; 2.A.1.82.6; the major facilitator superfamily (mfs).
DR iPTMnet; Q8N434; -.
DR PhosphoSitePlus; Q8N434; -.
DR BioMuta; SVOPL; -.
DR DMDM; 152112307; -.
DR MassIVE; Q8N434; -.
DR PaxDb; Q8N434; -.
DR PeptideAtlas; Q8N434; -.
DR PRIDE; Q8N434; -.
DR Antibodypedia; 18208; 95 antibodies from 16 providers.
DR DNASU; 136306; -.
DR Ensembl; ENST00000288513.9; ENSP00000288513.5; ENSG00000157703.16. [Q8N434-2]
DR Ensembl; ENST00000419765.4; ENSP00000405482.2; ENSG00000157703.16. [Q8N434-1]
DR Ensembl; ENST00000436657.5; ENSP00000417018.1; ENSG00000157703.16. [Q8N434-2]
DR Ensembl; ENST00000674285.1; ENSP00000501457.1; ENSG00000157703.16. [Q8N434-1]
DR GeneID; 136306; -.
DR KEGG; hsa:136306; -.
DR MANE-Select; ENST00000674285.1; ENSP00000501457.1; NM_001139456.2; NP_001132928.1.
DR UCSC; uc003vue.4; human. [Q8N434-1]
DR CTD; 136306; -.
DR GeneCards; SVOPL; -.
DR HGNC; HGNC:27034; SVOPL.
DR HPA; ENSG00000157703; Tissue enhanced (parathyroid gland, salivary gland).
DR MIM; 611700; gene.
DR neXtProt; NX_Q8N434; -.
DR OpenTargets; ENSG00000157703; -.
DR PharmGKB; PA162405089; -.
DR VEuPathDB; HostDB:ENSG00000157703; -.
DR eggNOG; KOG0253; Eukaryota.
DR GeneTree; ENSGT00940000158632; -.
DR HOGENOM; CLU_001265_46_0_1; -.
DR InParanoid; Q8N434; -.
DR OMA; QIWIIWL; -.
DR OrthoDB; 1430447at2759; -.
DR PhylomeDB; Q8N434; -.
DR TreeFam; TF313465; -.
DR PathwayCommons; Q8N434; -.
DR SignaLink; Q8N434; -.
DR BioGRID-ORCS; 136306; 9 hits in 1072 CRISPR screens.
DR ChiTaRS; SVOPL; human.
DR GenomeRNAi; 136306; -.
DR Pharos; Q8N434; Tdark.
DR PRO; PR:Q8N434; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8N434; protein.
DR Bgee; ENSG00000157703; Expressed in secondary oocyte and 94 other tissues.
DR ExpressionAtlas; Q8N434; baseline and differential.
DR Genevisible; Q8N434; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..492
FT /note="Putative transporter SVOPL"
FT /id="PRO_0000294461"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..478
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..152
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026651"
FT VAR_SEQ 153..157
FT /note="GHSQG -> MAAGR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026652"
FT VARIANT 385
FT /note="F -> C (in dbSNP:rs2305816)"
FT /id="VAR_033188"
SQ SEQUENCE 492 AA; 53991 MW; AB0460AAEEEC5F04 CRC64;
MATKPTEPVT ILSLRKLSLG TAEPQVKEPK TFTVEDAVET IGFGRFHIAL FLIMGSTGVV
EAMEIMLIAV VSPVIRCEWQ LENWQVALVT TMVFFGYMVF SILFGLLADR YGRWKILLIS
FLWGAYFSLL TSFAPSYIWF VFLRTMVGCG VSGHSQGLII KTEFLPTKYR GYMLPLSQVF
WLAGSLLIIG LASVIIPTIG WRWLIRVASI PGIILIVAFK FIPESARFNV STGNTRAALA
TLERVAKMNR SVMPEGKLVE PVLEKRGRFA DLLDAKYLRT TLQIWVIWLG ISFAYYGVIL
ASAELLERDL VCGSKSDSAV VVTGGDSGES QSPCYCHMFA PSDYRTMIIS TIGEIALNPL
NILGINFLGR RLSLSITMGC TALFFLLLNI CTSSAGLIGF LFMLRALVAA NFNTVYIYTA
EVYPTTMRAL GMGTSGSLCR IGAMVAPFIS QVLMSASILG ALCLFSSVCV VCAISAFTLP
IETKGRALQQ IK
