SVOPL_MOUSE
ID SVOPL_MOUSE Reviewed; 494 AA.
AC Q6PDF3; Q8BM44;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Putative transporter SVOPL;
DE AltName: Full=SVOP-like protein;
GN Name=Svopl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Embryoid bodies;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PDF3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PDF3-2; Sequence=VSP_026653, VSP_026654;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; AK034997; BAC28908.1; -; mRNA.
DR EMBL; AK137043; BAE23214.1; -; mRNA.
DR EMBL; BC058741; AAH58741.1; -; mRNA.
DR CCDS; CCDS20009.2; -. [Q6PDF3-1]
DR RefSeq; NP_796174.2; NM_177200.4. [Q6PDF3-1]
DR AlphaFoldDB; Q6PDF3; -.
DR STRING; 10090.ENSMUSP00000093743; -.
DR iPTMnet; Q6PDF3; -.
DR PhosphoSitePlus; Q6PDF3; -.
DR PaxDb; Q6PDF3; -.
DR PRIDE; Q6PDF3; -.
DR ProteomicsDB; 254725; -. [Q6PDF3-1]
DR ProteomicsDB; 254726; -. [Q6PDF3-2]
DR Antibodypedia; 18208; 95 antibodies from 16 providers.
DR DNASU; 320590; -.
DR Ensembl; ENSMUST00000096040; ENSMUSP00000093743; ENSMUSG00000029830. [Q6PDF3-1]
DR GeneID; 320590; -.
DR KEGG; mmu:320590; -.
DR UCSC; uc009bjm.1; mouse. [Q6PDF3-1]
DR UCSC; uc009bjn.1; mouse. [Q6PDF3-2]
DR CTD; 136306; -.
DR MGI; MGI:2444335; Svopl.
DR VEuPathDB; HostDB:ENSMUSG00000029830; -.
DR eggNOG; KOG0253; Eukaryota.
DR GeneTree; ENSGT00940000158632; -.
DR HOGENOM; CLU_001265_46_0_1; -.
DR InParanoid; Q6PDF3; -.
DR OMA; QIWIIWL; -.
DR OrthoDB; 1430447at2759; -.
DR PhylomeDB; Q6PDF3; -.
DR TreeFam; TF313465; -.
DR BioGRID-ORCS; 320590; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Svopl; mouse.
DR PRO; PR:Q6PDF3; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q6PDF3; protein.
DR Bgee; ENSMUSG00000029830; Expressed in olfactory epithelium and 100 other tissues.
DR ExpressionAtlas; Q6PDF3; baseline and differential.
DR Genevisible; Q6PDF3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..494
FT /note="Putative transporter SVOPL"
FT /id="PRO_0000294462"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 359..377
FT /note="LNPLNILGINFLGRRLSLS -> CKIAHVPALFQAGFLQLRD (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026653"
FT VAR_SEQ 378..494
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026654"
SQ SEQUENCE 494 AA; 54461 MW; 14E54B9FA4CFE361 CRC64;
MAAKQTEPVT IISLRKLSQA APEPQQKETK TFTVEDAVET IGFGRFHIAL FLIMGSTGVV
EAMEIMLIAV VSPVIRCEWQ LENWQVAFVT TMVFFGYMVS SILFGLLADR YGRWKILLLS
FLWGAYFSLL TSFSPSYIWF VFLRTMVGCG VSGHAQGLII KTEFLPTKYR GYMLPLSQVF
WLAGSLLIIS MASVVIPTIG WRWLIRIASI PGIILIMAFK FIPESARFNV STGNTQAALN
TLESIAKMNR SVMPEGQLVE PILEKRGRFA DLLDSKYLRT TLQIWIIWLG ISFAYYGVIL
ASAELLERDL VCGSKSESEP EVVETTGDSG EGLSPCYCHI FAPSDYRTMI ISTLGEIALN
PLNILGINFL GRRLSLSITM GCTALFFLLL NICTSSAGLI GFLFMLRALV AANFNTIYIY
TAEVYPTPMR AIGMGTSGSL CRIGAMVAPF ISQVLMSASF LGALCLFSSV CVVCAISAFT
LPIETKGRAL QQIK
