SVOP_BOVIN
ID SVOP_BOVIN Reviewed; 548 AA.
AC Q1JP63; Q17QM3;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Synaptic vesicle 2-related protein;
DE Short=SV2-related protein;
GN Name=SVOP;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Hereford; TISSUE=Brain cortex;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=9801366; DOI=10.1523/jneurosci.18-22-09269.1998;
RA Janz R., Hofmann K., Suedhof T.C.;
RT "SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel
RT transport functions of synaptic vesicles.";
RL J. Neurosci. 18:9269-9281(1998).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle membrane {ECO:0000269|PubMed:9801366}; Multi-pass membrane
CC protein {ECO:0000269|PubMed:9801366}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q1JP63-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q1JP63-2; Sequence=VSP_023442, VSP_023443;
CC -!- TISSUE SPECIFICITY: Detected in brain and adrenal medulla.
CC {ECO:0000269|PubMed:9801366}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; BT025491; ABF57447.1; -; mRNA.
DR EMBL; BC118274; AAI18275.1; -; mRNA.
DR RefSeq; NP_001068909.1; NM_001075441.1. [Q1JP63-1]
DR AlphaFoldDB; Q1JP63; -.
DR SMR; Q1JP63; -.
DR STRING; 9913.ENSBTAP00000029564; -.
DR PaxDb; Q1JP63; -.
DR Ensembl; ENSBTAT00000029565; ENSBTAP00000029564; ENSBTAG00000018833. [Q1JP63-1]
DR GeneID; 510256; -.
DR KEGG; bta:510256; -.
DR CTD; 55530; -.
DR VEuPathDB; HostDB:ENSBTAG00000018833; -.
DR eggNOG; KOG0253; Eukaryota.
DR eggNOG; KOG0255; Eukaryota.
DR GeneTree; ENSGT00940000155403; -.
DR HOGENOM; CLU_001265_46_0_1; -.
DR InParanoid; Q1JP63; -.
DR OMA; EIFPTKD; -.
DR OrthoDB; 1430447at2759; -.
DR TreeFam; TF313465; -.
DR Proteomes; UP000009136; Chromosome 17.
DR Bgee; ENSBTAG00000018833; Expressed in Ammon's horn and 63 other tissues.
DR ExpressionAtlas; Q1JP63; baseline and differential.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004749; Orgcat_transp/SVOP.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00898; 2A0119; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasmic vesicle; Membrane; Phosphoprotein;
KW Reference proteome; Synapse; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..548
FT /note="Synaptic vesicle 2-related protein"
FT /id="PRO_0000279451"
FT TOPO_DOM 1..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..122
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..180
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..209
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..238
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 338..373
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 395..401
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 402..422
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 423..425
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 426..446
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 447..457
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..478
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 479..489
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 490..510
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 511..548
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 528..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 25
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BFT9"
FT MOD_RES 31
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BFT9"
FT MOD_RES 542
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BFT9"
FT VAR_SEQ 451..468
FT /note="VYPTATRALGLGTCSGMA -> LRSAQLSRALTLSHHPKS (in isoform
FT 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_023442"
FT VAR_SEQ 469..548
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_023443"
SQ SEQUENCE 548 AA; 60748 MW; B9EB7CC19206D813 CRC64;
MEEDLFQLRQ LPVVKFRRTG ESARSEDDTA SGEHEVQIEG VRAGLEAVEL DDGAAVPKEF
ANPTDDTFMV EDAVEAIGFG KFQWKLSVLT GLAWMADAME MMILSILAPQ LHCEWRLPSW
QVALLTSVVF VGMMSSSTLW GNISDQYGRK TGLKISVLWT LYYGILSAFA PVYSWILVLR
GLVGFGIGGV PQSVTLYAEF LPMKARAKCI LLIEVFWAIG TVFEVVLAVF VMPSLGWRWL
LILSAVPLLL FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE
DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCSI SSRKKAVEAK
CSLACEYLSE EDYMDLLWTT LSEFPGVLVT LWIIDRLGRK KTMALCFVVF SFCSLLLFIC
VGRNMLTLLL FIARAFISGG FQAAYVYTPE VYPTATRALG LGTCSGMARV GALITPFIAQ
VMLESSVYLT LAVYSGCCLL AALASCFLPI ETKGRGLQES SHREWGQEMV GRGAHGTGVA
RSNSGSQE
