SVOP_HUMAN
ID SVOP_HUMAN Reviewed; 548 AA.
AC Q8N4V2; Q9NPW5;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Synaptic vesicle 2-related protein;
DE Short=SV2-related protein;
GN Name=SVOP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 405-548.
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP IDENTIFICATION.
RX PubMed=17714910; DOI=10.1016/j.ygeno.2007.03.017;
RA Jacobsson J.A., Haitina T., Lindblom J., Fredriksson R.;
RT "Identification of six putative human transporters with structural
RT similarity to the drug transporter SLC22 family.";
RL Genomics 90:595-609(2007).
CC -!- INTERACTION:
CC Q8N4V2; Q9H0Q3: FXYD6; NbExp=4; IntAct=EBI-12883142, EBI-713304;
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; BC033587; AAH33587.1; -; mRNA.
DR EMBL; BC094722; AAH94722.1; -; mRNA.
DR EMBL; AL359592; CAB94878.3; -; mRNA.
DR CCDS; CCDS73520.1; -.
DR PIR; T50622; T50622.
DR RefSeq; NP_061181.1; NM_018711.4.
DR AlphaFoldDB; Q8N4V2; -.
DR SMR; Q8N4V2; -.
DR BioGRID; 120701; 9.
DR IntAct; Q8N4V2; 5.
DR MINT; Q8N4V2; -.
DR STRING; 9606.ENSP00000479104; -.
DR iPTMnet; Q8N4V2; -.
DR PhosphoSitePlus; Q8N4V2; -.
DR BioMuta; SVOP; -.
DR DMDM; 74751007; -.
DR MassIVE; Q8N4V2; -.
DR PaxDb; Q8N4V2; -.
DR PeptideAtlas; Q8N4V2; -.
DR PRIDE; Q8N4V2; -.
DR ProteomicsDB; 71980; -.
DR Antibodypedia; 9307; 126 antibodies from 26 providers.
DR DNASU; 55530; -.
DR Ensembl; ENST00000610966.5; ENSP00000479104.1; ENSG00000166111.10.
DR GeneID; 55530; -.
DR KEGG; hsa:55530; -.
DR MANE-Select; ENST00000610966.5; ENSP00000479104.1; NM_018711.5; NP_061181.1.
DR UCSC; uc031zmo.2; human.
DR CTD; 55530; -.
DR GeneCards; SVOP; -.
DR HGNC; HGNC:25417; SVOP.
DR HPA; ENSG00000166111; Group enriched (brain, pituitary gland, retina).
DR MIM; 611699; gene.
DR neXtProt; NX_Q8N4V2; -.
DR OpenTargets; ENSG00000166111; -.
DR PharmGKB; PA142670848; -.
DR VEuPathDB; HostDB:ENSG00000166111; -.
DR eggNOG; KOG0253; Eukaryota.
DR eggNOG; KOG0255; Eukaryota.
DR GeneTree; ENSGT00940000155403; -.
DR HOGENOM; CLU_001265_46_0_1; -.
DR InParanoid; Q8N4V2; -.
DR OMA; EIFPTKD; -.
DR OrthoDB; 1430447at2759; -.
DR PhylomeDB; Q8N4V2; -.
DR TreeFam; TF313465; -.
DR PathwayCommons; Q8N4V2; -.
DR SignaLink; Q8N4V2; -.
DR BioGRID-ORCS; 55530; 7 hits in 244 CRISPR screens.
DR ChiTaRS; SVOP; human.
DR GenomeRNAi; 55530; -.
DR Pharos; Q8N4V2; Tbio.
DR PRO; PR:Q8N4V2; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8N4V2; protein.
DR Bgee; ENSG00000166111; Expressed in endothelial cell and 107 other tissues.
DR ExpressionAtlas; Q8N4V2; baseline and differential.
DR Genevisible; Q8N4V2; HS.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0008021; C:synaptic vesicle; ISS:HGNC-UCL.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004749; Orgcat_transp/SVOP.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00898; 2A0119; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Membrane; Phosphoprotein; Reference proteome; Synapse;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..548
FT /note="Synaptic vesicle 2-related protein"
FT /id="PRO_0000279452"
FT TOPO_DOM 1..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..122
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..180
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..209
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..238
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 338..373
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 395..401
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 402..422
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 423..424
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 446..457
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..478
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 479..489
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT TRANSMEM 490..510
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 511..548
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 25
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BFT9"
FT MOD_RES 31
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BFT9"
FT MOD_RES 542
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BFT9"
SQ SEQUENCE 548 AA; 60769 MW; 666116BD99516567 CRC64;
MEEDLFQLRQ LPVVKFRRTG ESARSEDDTA SGEHEVQIEG VHVGLEAVEL DDGAAVPKEF
ANPTDDTFMV EDAVEAIGFG KFQWKLSVLT GLAWMADAME MMILSILAPQ LHCEWRLPSW
QVALLTSVVF VGMMSSSTLW GNISDQYGRK TGLKISVLWT LYYGILSAFA PVYSWILVLR
GLVGFGIGGV PQSVTLYAEF LPMKARAKCI LLIEVFWAIG TVFEVVLAVF VMPSLGWRWL
LILSAVPLLL FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE
DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCGI SSRKKAVEAK
CSLACEYLSE EDYMDLLWTT LSEFPGVLVT LWIIDRLGRK KTMALCFVIF SFCSLLLFIC
VGRNVLTLLL FIARAFISGG FQAAYVYTPE VYPTATRALG LGTCSGMARV GALITPFIAQ
VMLESSVYLT LAVYSGCCLL AALASCFLPI ETKGRGLQES SHREWGQEMV GRGMHGAGVT
RSNSGSQE
