ID   SVOP_RAT                Reviewed;         548 AA.
AC   Q9Z2I7;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Synaptic vesicle 2-related protein;
DE            Short=SV2-related protein;
GN   Name=Svop;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Brain;
RX   PubMed=9801366; DOI=10.1523/jneurosci.18-22-09269.1998;
RA   Janz R., Hofmann K., Suedhof T.C.;
RT   "SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel
RT   transport functions of synaptic vesicles.";
RL   J. Neurosci. 18:9269-9281(1998).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25 AND SER-31, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC       vesicle membrane {ECO:0000269|PubMed:9801366}; Multi-pass membrane
CC       protein {ECO:0000269|PubMed:9801366}.
CC   -!- TISSUE SPECIFICITY: Detected in brain (at protein level). Detected in
CC       brain, in synaptic layers of the cerebellum, hippocampus and cerebral
CC       cortex. {ECO:0000269|PubMed:9801366}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF060173; AAC78627.1; -; mRNA.
DR   RefSeq; NP_599231.2; NM_134404.2.
DR   RefSeq; XP_008767537.1; XM_008769315.2.
DR   AlphaFoldDB; Q9Z2I7; -.
DR   SMR; Q9Z2I7; -.
DR   STRING; 10116.ENSRNOP00000000874; -.
DR   iPTMnet; Q9Z2I7; -.
DR   PhosphoSitePlus; Q9Z2I7; -.
DR   PRIDE; Q9Z2I7; -.
DR   ABCD; Q9Z2I7; 2 sequenced antibodies.
DR   GeneID; 171442; -.
DR   KEGG; rno:171442; -.
DR   UCSC; RGD:620277; rat.
DR   CTD; 55530; -.
DR   RGD; 620277; Svop.
DR   VEuPathDB; HostDB:ENSRNOG00000000693; -.
DR   eggNOG; KOG0253; Eukaryota.
DR   eggNOG; KOG0255; Eukaryota.
DR   HOGENOM; CLU_001265_46_0_1; -.
DR   InParanoid; Q9Z2I7; -.
DR   OMA; EIFPTKD; -.
DR   OrthoDB; 1430447at2759; -.
DR   PRO; PR:Q9Z2I7; -.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000000693; Expressed in frontal cortex and 9 other tissues.
DR   ExpressionAtlas; Q9Z2I7; baseline and differential.
DR   Genevisible; Q9Z2I7; RN.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008021; C:synaptic vesicle; IDA:HGNC-UCL.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR004749; Orgcat_transp/SVOP.
DR   Pfam; PF07690; MFS_1; 1.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00898; 2A0119; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   1: Evidence at protein level;
KW   Cytoplasmic vesicle; Membrane; Phosphoprotein; Reference proteome; Synapse;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..548
FT                   /note="Synaptic vesicle 2-related protein"
FT                   /id="PRO_0000279455"
FT   TOPO_DOM        1..87
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        109..122
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..156
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        178..180
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        202..209
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        231..238
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..316
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        338..373
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        395..401
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        423..424
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        425..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        446..457
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        479..489
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        490..510
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        511..548
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          523..548
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        530..548
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         25
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         31
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         542
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BFT9"
SQ   SEQUENCE   548 AA;  60804 MW;  19AD8475B7579496 CRC64;
     MEEDLFQLRQ LPVVKFRRTG ESARSEDDAA SGEHDVQIEG VRVGLEAVEL DDGAAVPKEF
     ANPTDDTFMV EDAVEAIGFG RFQWKLSVLT GLAWMADAME MMILSILAPQ LHCEWRLPSW
     QVALLTSVVF IGMMSSSTLW GNISDQYGRK TGLKISVFWT LYYGILSAFA PVYSWILVLR
     GLVGFGIGGV PQSVTLYAEF LPMKARAKCI LLIEVFWAIG TVFEVLLAVF VMPSLGWRWL
     LLLSAAPLLV FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE
     DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCSI SSRKKAVEAK
     CSLACEYLSK EDYMDLLWTT LSEFPGVLVT LWVIDRLGRK KTMALCFVIF SLCSLLLFIC
     IGRNVLTLLL FIARAFISGG FQAAYVYTPE VYPTATRALG LGTCSGMARV GALITPFIAQ
     VMLESSVYLT LAVYSGCCLL AALASCFLPI ETKGRALQES SHREWGQEMV GRGTNSTGVP
     RSNSGSQE