ID   SVOP_XENLA              Reviewed;         548 AA.
AC   Q2XWK0;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Synaptic vesicle 2-related protein;
DE            Short=SV2-related protein;
GN   Name=svop;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC   TISSUE=Embryo;
RX   PubMed=16217738; DOI=10.1002/dvdy.20618;
RA   Logan M.A., Steele M.R., Vetter M.L.;
RT   "Expression of synaptic vesicle two-related protein SVOP in the developing
RT   nervous system of Xenopus laevis.";
RL   Dev. Dyn. 234:802-807(2005).
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC       vesicle membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Detected in embryonic trigeminal ganglion and
CC       spinal cord. {ECO:0000269|PubMed:16217738}.
CC   -!- DEVELOPMENTAL STAGE: Expression increases continuously throughout
CC       embryonic development. First detected in embryos at day 12.
CC       {ECO:0000269|PubMed:16217738}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; DQ167576; ABA54609.1; -; mRNA.
DR   RefSeq; NP_001089190.1; NM_001095721.1.
DR   AlphaFoldDB; Q2XWK0; -.
DR   SMR; Q2XWK0; -.
DR   GeneID; 734235; -.
DR   KEGG; xla:734235; -.
DR   CTD; 734235; -.
DR   Xenbase; XB-GENE-939909; svop.L.
DR   OMA; EIFPTKD; -.
DR   OrthoDB; 1430447at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 734235; Expressed in brain and 8 other tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Membrane; Reference proteome; Synapse; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..548
FT                   /note="Synaptic vesicle 2-related protein"
FT                   /id="PRO_0000279456"
FT   TOPO_DOM        1..87
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        109..119
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        141..156
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        178..180
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        202..209
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        231..238
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..316
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        338..373
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        395..401
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        423..424
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        425..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        446..457
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        479..486
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        487..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        508..548
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          519..548
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   548 AA;  60995 MW;  89B6F9EAFF5F4D48 CRC64;
     MEDDLFQLRH LPVVKFRRTG ESSKSEDDNI SGEHEIQIGP VQTELEAVEL EDGTTVPKEF
     ANPTDDTFMV EDAVEAIGFG KFQWKLSMLT GLAWMADAME MMILSILAPQ LHCEWRLPSW
     QVALLTSVVF IGMMASSSLW GNVSDQYGRR TGLKISVIWT LYYGILSAFA PVYSWILVLR
     GLVGFGIGGV PQSVTLYAEF LPMKSRAKCI LLIEIFWALG TVFEVLLAIF VMPTLGWRWL
     LILSALPLML FAILCFWLPE SARYEVLSGN QEKALATLKR IATENGAPMP LGKLIVSRQE
     DRGKIRDLFS PQFRCTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCSI SNQRKAVKPK
     CSLACEYLTV EDYTDLLWTT LSEFPGLLVT LWIIDRVGRK KTMAICFIIF SFSALLLFLC
     VGRNVLTVFL FIARAFISGG FQAAYVYTPE VYPTATRALG LGTCSGMARV GALITPFIAQ
     VMLESSIYLT VLVYSGCCVL AAVASCFLPI ETKGRGLQES SHREWGQEMV GRGTHNVGAT
     PSHSGSQE