ID   SVP2_CAVPO              Reviewed;         132 AA.
AC   P16531;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Seminal vesicle protein SVP-2;
DE   Flags: Precursor; Fragment;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND PROTEIN SEQUENCE OF
RP   15-39.
RX   PubMed=2691882; DOI=10.1210/mend-3-11-1797;
RA   Hagstrom J.E., Harvey S., Madden B., McCormick D., Wieben E.D.;
RT   "Androgens affect the processing of secretory protein precursors in the
RT   guinea pig seminal vesicle. II. Identification of conserved sites for
RT   protein processing.";
RL   Mol. Endocrinol. 3:1797-1806(1989).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P16531-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P16531-2; Sequence=VSP_004437;
CC   -!- MISCELLANEOUS: SVP-2 is one of the 4 major secretory proteins, secreted
CC       by the guinea pig seminal vesicle epithelium (sve).
CC   -!- SIMILARITY: To the SVP-1/-3/-4 precursor, particularly in regions where
CC       protein processing must occur. {ECO:0000305}.
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DR   EMBL; M31653; AAA37055.1; -; mRNA.
DR   PIR; A41405; A41405.
DR   AlphaFoldDB; P16531; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Reference proteome; Secreted; Signal.
FT   SIGNAL          <1..14
FT                   /evidence="ECO:0000269|PubMed:2691882"
FT   CHAIN           15..103
FT                   /note="Seminal vesicle protein SVP-2"
FT                   /id="PRO_0000022446"
FT   PROPEP          104..132
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000022447"
FT   REGION          33..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          113..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         18
FT                   /note="R -> RA (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:2691882"
FT                   /id="VSP_004437"
FT   VARIANT         95
FT                   /note="S -> L"
FT   NON_TER         1
SQ   SEQUENCE   132 AA;  14926 MW;  714EEE7B8EE9CA95 CRC64;
     HLALLLILEN QASGRRLRGS ARAQDPVVSR VWHKEEVEES ESSRGQDFDK RRFWEKDDPT
     GEHVSVRHEH LEKSHIRFKE DSIDDSGSAG GLNPSKGHLR LKRHDAMEEL VSVEDQALAN
     GADPGKSNMQ RV