SVP_ARATH
ID SVP_ARATH Reviewed; 240 AA.
AC Q9FVC1; A7XFT9; Q9SJY1;
DT 05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=MADS-box protein SVP {ECO:0000303|PubMed:10758486};
DE AltName: Full=Protein SHORT VEGETATIVE PHASE {ECO:0000303|PubMed:10758486};
GN Name=SVP {ECO:0000303|PubMed:10758486};
GN OrderedLocusNames=At2g22540 {ECO:0000312|Araport:AT2G22540};
GN ORFNames=F14M13.6 {ECO:0000312|EMBL:AAD22365.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, AND MUTANT
RP SVP-43.
RC STRAIN=cv. Columbia;
RX PubMed=10758486; DOI=10.1046/j.1365-313x.2000.00682.x;
RA Hartmann U., Hohmann S., Nettesheim K., Wisman E., Saedler H., Huijser P.;
RT "Molecular cloning of SVP: a negative regulator of the floral transition in
RT Arabidopsis.";
RL Plant J. 21:351-360(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=cv. Columbia;
RA Li X., An Y.;
RT "A new alternative splicing of SVP gene from Arabidopsis inflorescence.";
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP INTERACTION WITH AGL15.
RX PubMed=15805477; DOI=10.1105/tpc.105.031831;
RA de Folter S., Immink R.G.H., Kieffer M., Parenicova L., Henz S.R.,
RA Weigel D., Busscher M., Kooiker M., Colombo L., Kater M.M., Davies B.,
RA Angenent G.C.;
RT "Comprehensive interaction map of the Arabidopsis MADS Box transcription
RT factors.";
RL Plant Cell 17:1424-1433(2005).
RN [6]
RP INDUCTION BY HUA2.
RX PubMed=15659097; DOI=10.1111/j.1365-313x.2004.02300.x;
RA Doyle M.R., Bizzell C.M., Keller M.R., Michaels S.D., Song J., Noh Y.-S.,
RA Amasino R.M.;
RT "HUA2 is required for the expression of floral repressors in Arabidopsis
RT thaliana.";
RL Plant J. 41:376-385(2005).
RN [7]
RP FUNCTION, AND INTERACTION WITH AP1; SEU AND LUG.
RX PubMed=16679456; DOI=10.1105/tpc.106.041798;
RA Gregis V., Sessa A., Colombo L., Kater M.M.;
RT "AGL24, SHORT VEGETATIVE PHASE, and APETALA1 redundantly control AGAMOUS
RT during early stages of flower development in Arabidopsis.";
RL Plant Cell 18:1373-1382(2006).
RN [8]
RP INDUCTION BY AP1.
RX PubMed=17428825; DOI=10.1242/dev.003103;
RA Liu C., Zhou J., Bracha-Drori K., Yalovsky S., Ito T., Yu H.;
RT "Specification of Arabidopsis floral meristem identity by repression of
RT flowering time genes.";
RL Development 134:1901-1910(2007).
RN [9]
RP FUNCTION, AND INDUCTION.
RX PubMed=18694458; DOI=10.1111/j.1365-313x.2008.03648.x;
RA Gregis V., Sessa A., Colombo L., Kater M.M.;
RT "AGAMOUS-LIKE24 and SHORT VEGETATIVE PHASE determine floral meristem
RT identity in Arabidopsis.";
RL Plant J. 56:891-902(2008).
RN [10]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=19656343; DOI=10.1111/j.1365-313x.2009.03985.x;
RA Gregis V., Sessa A., Dorca-Fornell C., Kater M.M.;
RT "The Arabidopsis floral meristem identity genes AP1, AGL24 and SVP directly
RT repress class B and C floral homeotic genes.";
RL Plant J. 60:626-637(2009).
RN [11]
RP FUNCTION.
RX PubMed=25132385; DOI=10.1016/j.devcel.2014.07.004;
RA Yan Y., Shen L., Chen Y., Bao S., Thong Z., Yu H.;
RT "A MYB-domain protein EFM mediates flowering responses to environmental
RT cues in Arabidopsis.";
RL Dev. Cell 30:437-448(2014).
RN [12]
RP INTERACTION WITH AGL16.
RX PubMed=24876250; DOI=10.1105/tpc.114.124685;
RA Hu J.Y., Zhou Y., He F., Dong X., Liu L.Y., Coupland G., Turck F.,
RA de Meaux J.;
RT "miR824-regulated AGAMOUS-LIKE16 contributes to flowering time repression
RT in Arabidopsis.";
RL Plant Cell 26:2024-2037(2014).
CC -!- FUNCTION: Transcription repressor that inhibit floral transition in the
CC autonomous flowering pathway, independent of photoperiod and
CC temperature. Acts in a dosage-dependent manner. Together with AGL24 and
CC AP1, controls the identity of the floral meristem and regulates
CC expression of class B, C and E genes. Promotes EFM expression to
CC suppress flowering (PubMed:25132385). {ECO:0000269|PubMed:16679456,
CC ECO:0000269|PubMed:18694458, ECO:0000269|PubMed:19656343,
CC ECO:0000269|PubMed:25132385}.
CC -!- SUBUNIT: Forms a heterodimer with AP1 and SVP. Interacts with the SEU-
CC LUG corepressor complex when complexed to AP1. Interacts with AGL15
CC (PubMed:15805477, PubMed:16679456). Interacts with AGL16
CC (PubMed:24876250). {ECO:0000269|PubMed:15805477,
CC ECO:0000269|PubMed:16679456, ECO:0000269|PubMed:24876250}.
CC -!- INTERACTION:
CC Q9FVC1; Q38838: AGL14; NbExp=4; IntAct=EBI-592058, EBI-622067;
CC Q9FVC1; Q9SZJ6: AGL21; NbExp=5; IntAct=EBI-592058, EBI-621986;
CC Q9FVC1; Q9AT76-1: AGL27; NbExp=7; IntAct=EBI-592058, EBI-16074648;
CC Q9FVC1; P29385: AGL5; NbExp=4; IntAct=EBI-592058, EBI-621949;
CC Q9FVC1; P35631: AP1; NbExp=5; IntAct=EBI-592058, EBI-592003;
CC Q9FVC1; O82343: At2g46260; NbExp=3; IntAct=EBI-592058, EBI-15192211;
CC Q9FVC1; Q9S7Q7: FLC; NbExp=4; IntAct=EBI-592058, EBI-2127872;
CC Q9FVC1; Q9SQI2: GI; NbExp=2; IntAct=EBI-592058, EBI-446380;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251,
CC ECO:0000269|PubMed:19656343}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=Long;
CC IsoId=Q9FVC1-1; Sequence=Displayed;
CC Name=2; Synonyms=Short;
CC IsoId=Q9FVC1-2; Sequence=VSP_006255, VSP_006256;
CC Name=3;
CC IsoId=Q9FVC1-3; Sequence=VSP_039686;
CC -!- TISSUE SPECIFICITY: Detected in roots and leaves. Expressed at very low
CC levels in flowers and siliques. Present in floral meristems.
CC {ECO:0000269|PubMed:19656343}.
CC -!- DEVELOPMENTAL STAGE: During vegetative phase expressed in young leaves
CC and apical meristem until early stage of bolting. Early in development
CC of the inflorescence present in the coflorescence and flower primordia
CC but not in the main apical meristem. Present throughout the floral
CC meristem during early stages of flower development. Later disappears
CC prior to emergence of sepal primordia. {ECO:0000269|PubMed:19656343}.
CC -!- INDUCTION: Repressed by the floral homeotic genes AP1 and SEP3 in
CC emerging floral meristems. Up-regulated by HUA2.
CC {ECO:0000269|PubMed:15659097, ECO:0000269|PubMed:17428825,
CC ECO:0000269|PubMed:18694458}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD22365.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF211171; AAG24508.1; -; mRNA.
DR EMBL; EU078686; ABU95407.1; -; mRNA.
DR EMBL; AC006592; AAD22365.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC07320.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07321.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM62426.1; -; Genomic_DNA.
DR RefSeq; NP_001154528.1; NM_001161056.1. [Q9FVC1-3]
DR RefSeq; NP_001324584.1; NM_001335800.1. [Q9FVC1-1]
DR RefSeq; NP_179840.2; NM_127820.4. [Q9FVC1-1]
DR AlphaFoldDB; Q9FVC1; -.
DR SMR; Q9FVC1; -.
DR BioGRID; 2140; 30.
DR DIP; DIP-33797N; -.
DR IntAct; Q9FVC1; 26.
DR STRING; 3702.AT2G22540.1; -.
DR PaxDb; Q9FVC1; -.
DR PRIDE; Q9FVC1; -.
DR ProteomicsDB; 226795; -. [Q9FVC1-1]
DR EnsemblPlants; AT2G22540.1; AT2G22540.1; AT2G22540. [Q9FVC1-1]
DR EnsemblPlants; AT2G22540.2; AT2G22540.2; AT2G22540. [Q9FVC1-3]
DR EnsemblPlants; AT2G22540.3; AT2G22540.3; AT2G22540. [Q9FVC1-1]
DR GeneID; 816787; -.
DR Gramene; AT2G22540.1; AT2G22540.1; AT2G22540. [Q9FVC1-1]
DR Gramene; AT2G22540.2; AT2G22540.2; AT2G22540. [Q9FVC1-3]
DR Gramene; AT2G22540.3; AT2G22540.3; AT2G22540. [Q9FVC1-1]
DR KEGG; ath:AT2G22540; -.
DR Araport; AT2G22540; -.
DR TAIR; locus:2041233; AT2G22540.
DR eggNOG; KOG0014; Eukaryota.
DR HOGENOM; CLU_053053_14_1_1; -.
DR InParanoid; Q9FVC1; -.
DR OMA; QIYNNVH; -.
DR PhylomeDB; Q9FVC1; -.
DR PRO; PR:Q9FVC1; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9FVC1; baseline and differential.
DR Genevisible; Q9FVC1; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000900; F:mRNA regulatory element binding translation repressor activity; IDA:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IPI:TAIR.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0009910; P:negative regulation of flower development; IMP:TAIR.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:TAIR.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0009266; P:response to temperature stimulus; IMP:TAIR.
DR CDD; cd00265; MADS_MEF2_like; 1.
DR Gene3D; 3.40.1810.10; -; 1.
DR InterPro; IPR033896; MADS_MEF2-like.
DR InterPro; IPR002487; TF_Kbox.
DR InterPro; IPR002100; TF_MADSbox.
DR InterPro; IPR036879; TF_MADSbox_sf.
DR Pfam; PF01486; K-box; 1.
DR Pfam; PF00319; SRF-TF; 1.
DR PRINTS; PR00404; MADSDOMAIN.
DR SMART; SM00432; MADS; 1.
DR SUPFAM; SSF55455; SSF55455; 1.
DR PROSITE; PS51297; K_BOX; 1.
DR PROSITE; PS00350; MADS_BOX_1; 1.
DR PROSITE; PS50066; MADS_BOX_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; Differentiation; DNA-binding;
KW Flowering; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..240
FT /note="MADS-box protein SVP"
FT /id="PRO_0000199487"
FT DOMAIN 3..57
FT /note="MADS-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT DOMAIN 87..180
FT /note="K-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00629"
FT REGION 202..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 56..61
FT /note="EFCSSS -> D (in isoform 3)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_039686"
FT VAR_SEQ 61..63
FT /note="SMK -> RKS (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_006255"
FT VAR_SEQ 64..240
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_006256"
FT MUTAGEN 65..68
FT /note="VLER->G: In svp-43; early flowering."
SQ SEQUENCE 240 AA; 26896 MW; C14F3B6A259DF26E CRC64;
MAREKIQIRK IDNATARQVT FSKRRRGLFK KAEELSVLCD ADVALIIFSS TGKLFEFCSS
SMKEVLERHN LQSKNLEKLD QPSLELQLVE NSDHARMSKE IADKSHRLRQ MRGEELQGLD
IEELQQLEKA LETGLTRVIE TKSDKIMSEI SELQKKGMQL MDENKRLRQQ GTQLTEENER
LGMQICNNVH AHGGAESENA AVYEEGQSSE SITNAGNSTG APVDSESSDT SLRLGLPYGG
