SVS4_MOUSE
ID SVS4_MOUSE Reviewed; 113 AA.
AC P18419; A2A4C3; Q14BU4; Q9D257;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Seminal vesicle secretory protein 4;
DE AltName: Full=Seminal vesicle protein 2;
DE AltName: Full=Seminal vesicle secretory protein IV;
DE Short=SVS IV;
DE Flags: Precursor;
GN Name=Svs4; Synonyms=Svp2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Epididymis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 6-113, AND PROTEIN SEQUENCE OF 56-108.
RC TISSUE=Seminal vesicle;
RX PubMed=2484712; DOI=10.1210/mend-1-10-707;
RA Chen Y.H., Pentecostt B.T., McLachlan J.A., Teng C.T.;
RT "The androgen-dependent mouse seminal vesicle secretory protein IV:
RT characterization and complementary deoxyribonucleic acid cloning.";
RL Mol. Endocrinol. 1:707-716(1987).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC -!- TISSUE SPECIFICITY: Testis.
CC -!- INDUCTION: By testosterone.
CC -!- SIMILARITY: Belongs to the SVP2/SVP5/SVP6 family. {ECO:0000305}.
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DR EMBL; AK020349; BAB32080.1; -; mRNA.
DR EMBL; AL590429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC115604; AAI15605.1; -; mRNA.
DR EMBL; BC115605; AAI15606.1; -; mRNA.
DR EMBL; M35732; AAA40158.1; -; mRNA.
DR CCDS; CCDS17029.1; -.
DR PIR; A40059; A40059.
DR RefSeq; NP_033326.1; NM_009300.3.
DR AlphaFoldDB; P18419; -.
DR STRING; 10090.ENSMUSP00000017142; -.
DR iPTMnet; P18419; -.
DR PhosphoSitePlus; P18419; -.
DR CPTAC; non-CPTAC-3501; -.
DR MaxQB; P18419; -.
DR PaxDb; P18419; -.
DR PeptideAtlas; P18419; -.
DR PRIDE; P18419; -.
DR ProteomicsDB; 258782; -.
DR DNASU; 20941; -.
DR Ensembl; ENSMUST00000017142; ENSMUSP00000017142; ENSMUSG00000016998.
DR GeneID; 20941; -.
DR KEGG; mmu:20941; -.
DR UCSC; uc008nue.1; mouse.
DR CTD; 20941; -.
DR MGI; MGI:98450; Svs4.
DR VEuPathDB; HostDB:ENSMUSG00000016998; -.
DR GeneTree; ENSGT00520000057703; -.
DR HOGENOM; CLU_2157587_0_0_1; -.
DR InParanoid; P18419; -.
DR OMA; DGSNMEG; -.
DR TreeFam; TF353660; -.
DR BioGRID-ORCS; 20941; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Svs4; mouse.
DR PRO; PR:P18419; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P18419; protein.
DR Bgee; ENSMUSG00000016998; Expressed in seminal vesicle and 26 other tissues.
DR Genevisible; P18419; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR InterPro; IPR035409; Svs4/5/6.
DR PANTHER; PTHR17498; PTHR17498; 1.
DR Pfam; PF17381; Svs_4_5_6; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000305"
FT CHAIN 22..113
FT /note="Seminal vesicle secretory protein 4"
FT /id="PRO_0000022452"
FT REGION 31..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 41
FT /note="M -> T (in Ref. 3; AAI15605/AAI15606 and 4;
FT AAA40158)"
FT /evidence="ECO:0000305"
FT CONFLICT 63
FT /note="I -> K (in Ref. 4; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 113 AA; 12515 MW; FCF4C7D2C553AFB8 CRC64;
MNSTSLFLFS LLLLLVTGAI GKKTKEKFLQ SEETVRESFS MGSRGHMSRS SEPEVFVRPQ
DSIGDEASEE MSSSSSSRRR SKIISSSSDG SNMEGESSYS KRKKSRFSQD ALE
