SVS4_RAT
ID SVS4_RAT Reviewed; 112 AA.
AC P02783; Q64713;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Seminal vesicle secretory protein 4;
DE AltName: Full=Androgen-dependent protein;
DE Short=ADP;
DE AltName: Full=Seminal vesicle protein 2;
DE AltName: Full=Seminal vesicle secretory protein IV;
DE Short=SVS IV;
DE Short=SVS protein S;
DE Flags: Precursor;
GN Name=Svs4; Synonyms=Svp2, Svp4;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=6164983; DOI=10.1093/nar/9.4.935;
RA Mansson P.E., Sugino A., Harris S.E.;
RT "Use of a cloned double stranded cDNA coding for a major androgen dependent
RT protein in rat seminal vesicle secretion: the effect of testosterone in
RT gene expression.";
RL Nucleic Acids Res. 9:935-946(1981).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=6579532; DOI=10.1073/pnas.80.21.6460;
RA Harris S.E., Mansson P.-E., Tully D.B., Burkhart B.;
RT "Seminal vesicle secretion IV gene: allelic difference due to a series of
RT 20-base-pair direct tandem repeats within an intron.";
RL Proc. Natl. Acad. Sci. U.S.A. 80:6460-6464(1983).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=6548962; DOI=10.1002/j.1460-2075.1984.tb02166.x;
RA McDonald C.J., Eliopoulos E., Higgins S.J.;
RT "Divergent protein coding regions in otherwise closely related androgen-
RT regulated mRNAs.";
RL EMBO J. 3:2517-2521(1984).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.
RX PubMed=6304626; DOI=10.1093/nar/11.10.3169;
RA Kandala J.C., Kistler M.K., Lawther R.P., Kistler W.S.;
RT "Characterization of a genomic clone for rat seminal vesicle secretory
RT protein IV.";
RL Nucleic Acids Res. 11:3169-3186(1983).
RN [5]
RP PROTEIN SEQUENCE OF 22-112.
RX PubMed=7007263; DOI=10.1111/j.1399-3011.1980.tb02947.x;
RA Pan Y.-C.E., Silverberg A.B., Harris S.E., Li S.S.-L.;
RT "Complete amino acid sequence of a major secretory protein from rat seminal
RT vesicle.";
RL Int. J. Pept. Protein Res. 16:143-146(1980).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC -!- TISSUE SPECIFICITY: Testis.
CC -!- INDUCTION: By testosterone.
CC -!- SIMILARITY: Belongs to the SVP2/SVP5/SVP6 family. {ECO:0000305}.
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DR EMBL; M25590; AAA40684.1; ALT_SEQ; mRNA.
DR EMBL; M16069; AAA42193.1; -; Genomic_DNA.
DR EMBL; X01114; CAA25584.1; -; mRNA.
DR EMBL; X01575; CAA25730.1; -; Genomic_DNA.
DR EMBL; M10097; AAA42194.1; -; Genomic_DNA.
DR PIR; A93975; SQRTSV.
DR PIR; I58340; I58340.
DR RefSeq; NP_036794.1; NM_012662.3.
DR RefSeq; XP_008760772.1; XM_008762550.2.
DR RefSeq; XP_008772092.1; XM_008773870.2.
DR RefSeq; XP_017458172.1; XM_017602683.1.
DR AlphaFoldDB; P02783; -.
DR iPTMnet; P02783; -.
DR PhosphoSitePlus; P02783; -.
DR PaxDb; P02783; -.
DR GeneID; 24802; -.
DR KEGG; rno:24802; -.
DR UCSC; RGD:3791; rat.
DR CTD; 20941; -.
DR RGD; 3791; Svs4.
DR InParanoid; P02783; -.
DR TreeFam; TF353660; -.
DR PRO; PR:P02783; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005615; C:extracellular space; IDA:CAFA.
DR GO; GO:0032991; C:protein-containing complex; IDA:CAFA.
DR GO; GO:0042802; F:identical protein binding; IDA:CAFA.
DR GO; GO:0043621; F:protein self-association; IDA:CAFA.
DR DisProt; DP00527; -.
DR InterPro; IPR035409; Svs4/5/6.
DR PANTHER; PTHR17498; PTHR17498; 1.
DR Pfam; PF17381; Svs_4_5_6; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000269|PubMed:7007263"
FT CHAIN 22..112
FT /note="Seminal vesicle secretory protein 4"
FT /id="PRO_0000022453"
FT REGION 26..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 50
FT /note="Missing (in Ref. 2; AAA42193)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 112 AA; 12046 MW; 979DF97633F8C6A0 CRC64;
MKSTSLFLCS LLLLLVTGAI GRKTKEKYSQ SEEVVSESFA SGPSSGSSDD ELVRDKPYGP
KVSGGSFGEE ASEEISSRRS KHISRSSGGS NMEGESSYAK KKRSRFAQDV LN
