SWAHA_HUMAN
ID SWAHA_HUMAN Reviewed; 549 AA.
AC Q2M3V2; Q8NAE7;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 4.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Ankyrin repeat domain-containing protein SOWAHA;
DE AltName: Full=Ankyrin repeat domain-containing protein 43;
DE AltName: Full=Protein sosondowah homolog A;
DE Flags: Precursor;
GN Name=SOWAHA; Synonyms=ANKRD43;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 192-549.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-549.
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
CC -!- SIMILARITY: Belongs to the SOWAH family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI04772.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI04776.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC03975.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC004775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC104771; AAI04772.1; ALT_INIT; mRNA.
DR EMBL; BC104775; AAI04776.1; ALT_INIT; mRNA.
DR EMBL; AK092782; BAC03975.1; ALT_INIT; mRNA.
DR CCDS; CCDS43361.1; -.
DR AlphaFoldDB; Q2M3V2; -.
DR IntAct; Q2M3V2; 1.
DR STRING; 9606.ENSP00000367965; -.
DR iPTMnet; Q2M3V2; -.
DR PhosphoSitePlus; Q2M3V2; -.
DR BioMuta; SOWAHA; -.
DR DMDM; 296439442; -.
DR jPOST; Q2M3V2; -.
DR MassIVE; Q2M3V2; -.
DR PaxDb; Q2M3V2; -.
DR PeptideAtlas; Q2M3V2; -.
DR PRIDE; Q2M3V2; -.
DR ProteomicsDB; 61383; -.
DR Antibodypedia; 74825; 4 antibodies from 4 providers.
DR Ensembl; ENST00000378693.4; ENSP00000367965.2; ENSG00000198944.6.
DR MANE-Select; ENST00000378693.4; ENSP00000367965.2; NM_175873.6; NP_787069.4.
DR UCSC; uc003kxw.4; human.
DR GeneCards; SOWAHA; -.
DR HGNC; HGNC:27033; SOWAHA.
DR HPA; ENSG00000198944; Group enriched (brain, intestine).
DR neXtProt; NX_Q2M3V2; -.
DR OpenTargets; ENSG00000198944; -.
DR PharmGKB; PA142672610; -.
DR VEuPathDB; HostDB:ENSG00000198944; -.
DR eggNOG; ENOG502RXAT; Eukaryota.
DR GeneTree; ENSGT00950000183003; -.
DR HOGENOM; CLU_041239_1_0_1; -.
DR InParanoid; Q2M3V2; -.
DR PhylomeDB; Q2M3V2; -.
DR TreeFam; TF331362; -.
DR PathwayCommons; Q2M3V2; -.
DR SignaLink; Q2M3V2; -.
DR Pharos; Q2M3V2; Tdark.
DR PRO; PR:Q2M3V2; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q2M3V2; protein.
DR Bgee; ENSG00000198944; Expressed in endothelial cell and 132 other tissues.
DR Genevisible; Q2M3V2; HS.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 1: Evidence at protein level;
KW ANK repeat; Phosphoprotein; Reference proteome; Repeat; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..549
FT /note="Ankyrin repeat domain-containing protein SOWAHA"
FT /id="PRO_0000244373"
FT REPEAT 345..374
FT /note="ANK 1"
FT REPEAT 384..414
FT /note="ANK 2"
FT REGION 82..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..135
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..162
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..210
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 260
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BLS7"
FT VARIANT 124
FT /note="R -> P (in dbSNP:rs40274)"
FT /id="VAR_059125"
FT VARIANT 545
FT /note="L -> F (in dbSNP:rs40470)"
FT /id="VAR_060465"
SQ SEQUENCE 549 AA; 57409 MW; 07401B2E21F34F6C CRC64;
MALAAAAAAA AAGVSQAAVL GFLQEHGGKV RNSELLSRFK PLLDAGDPRG RAARRDRFKQ
FVNNVAVVKE LDGVKFVVLR KKPRPPEPEP APFGPPGAAA QPSKPTSTVL PRSASAPGAP
PLVRVPRPVE PPGDLGLPTE PQDTPGGPAS EPAQPPGERS ADPPLPALEL AQATERPSAD
AAPPPRAPSE AASPCSDPPD AEPGPGAAKG PPQQKPCMLP VRCVPAPATL RLRAEEPGLR
RQLSEEPSPR SSPLLLRRLS VEESGLGLGL GPGRSPHLRR LSRAGPRLLS PDAEELPAAP
PPSAVPLEPS EHEWLVRTAG GRWTHQLHGL LLRDRGLAAK RDFMSGFTAL HWAAKSGDGE
MALQLVEVAR RSGAPVDVNA RSHGGYTPLH LAALHGHEDA AVLLVVRLGA QVHVRDHSGR
RAYQYLRPGS SYALRRLLGD PGLRGTTEPD ATGGGSGSLA ARRPVQVAAT ILSSTTSAFL
GVLADDLMLQ DLARGLKKSS SFSKFLSASP MAPRKKTKIR GGLPAFSEIS RRPTPGPLAG
LVPSLPPTT
