SWAHA_MOUSE
ID SWAHA_MOUSE Reviewed; 548 AA.
AC Q8BLS7; Q149C7;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Ankyrin repeat domain-containing protein SOWAHA;
DE AltName: Full=Ankyrin repeat domain-containing protein 43;
DE AltName: Full=Protein sosondowah homolog A;
DE Flags: Precursor;
GN Name=Sowaha; Synonyms=Ankrd43;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 126-548.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the SOWAH family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI17864.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC31573.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK043538; BAC31573.1; ALT_FRAME; mRNA.
DR EMBL; AL596095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC117863; AAI17864.1; ALT_INIT; mRNA.
DR CCDS; CCDS24681.2; -.
DR RefSeq; NP_898996.2; NM_183173.2.
DR AlphaFoldDB; Q8BLS7; -.
DR SMR; Q8BLS7; -.
DR STRING; 10090.ENSMUSP00000100561; -.
DR iPTMnet; Q8BLS7; -.
DR PhosphoSitePlus; Q8BLS7; -.
DR PaxDb; Q8BLS7; -.
DR PRIDE; Q8BLS7; -.
DR ProteomicsDB; 254613; -.
DR Antibodypedia; 74825; 4 antibodies from 4 providers.
DR Ensembl; ENSMUST00000104955; ENSMUSP00000100561; ENSMUSG00000044352.
DR GeneID; 237761; -.
DR KEGG; mmu:237761; -.
DR UCSC; uc007iwf.1; mouse.
DR CTD; 134548; -.
DR MGI; MGI:2687280; Sowaha.
DR VEuPathDB; HostDB:ENSMUSG00000044352; -.
DR eggNOG; ENOG502RXAT; Eukaryota.
DR GeneTree; ENSGT00950000183003; -.
DR HOGENOM; CLU_041239_1_0_1; -.
DR InParanoid; Q8BLS7; -.
DR OMA; KPYHYLR; -.
DR OrthoDB; 1531345at2759; -.
DR PhylomeDB; Q8BLS7; -.
DR TreeFam; TF331362; -.
DR BioGRID-ORCS; 237761; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8BLS7; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8BLS7; protein.
DR Bgee; ENSMUSG00000044352; Expressed in CA3 field of hippocampus and 112 other tissues.
DR Genevisible; Q8BLS7; MM.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 1: Evidence at protein level;
KW ANK repeat; Phosphoprotein; Reference proteome; Repeat; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..548
FT /note="Ankyrin repeat domain-containing protein SOWAHA"
FT /id="PRO_0000244374"
FT REPEAT 344..373
FT /note="ANK 1"
FT REPEAT 383..413
FT /note="ANK 2"
FT REGION 114..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..211
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 258
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 173
FT /note="L -> V (in Ref. 1; BAC31573)"
FT /evidence="ECO:0000305"
FT CONFLICT 244
FT /note="E -> K (in Ref. 3; AAI17864)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 548 AA; 57749 MW; BBE9044230D01D15 CRC64;
MALAAAAAAA AAAAGVSQAA VLGFLREHGG QVRNSELLSR FKPLLDAGDP RGRAARRDRF
KQFVNNVAVV KELDGVKFVV LRKKPRPPEG PEAPLPSSPG VPAALAQCAA VPAEDNCAPG
APHSPQRSGE PPEDSSAPSE LQHTPETLPS EVTQVEAPSG SAPQPGGPED PALPRSSELA
RPASVPSGLA LTSTESPGPE PAPPTAQVPP QKPCMLPVRC VVPGPAALRI RAEEQGLRRQ
RSEEPSPRGS PMLLRRLSVE ESGLGLHLGP GRSPHLRRLS RAGPRLLSPD TEEMPVAPLP
SPAVPLEPTE HEWLVRTASG RWSHQLHGLL LRDRGLAAKR DFMSGFTALH WAAKNGDREM
ALQLVEVARR GGAPVDVNAR SHGGYTPLHL AALHGHEDAA VLLVVRLGAQ VHVRDYSGRR
AYQYLRPGSS YALRRLLGDP GLRSMMEPDA ASGGSGSLVS RHPVQVAATI LSSTTSAFLG
VLADDLMLQD LARGLKKSSS FSKFLGASPM APRKKTKIRG GLPSFTEISH RSTPGPLAGL
VPSLPPPT
