SWAHB_HUMAN
ID SWAHB_HUMAN Reviewed; 793 AA.
AC A6NEL2; B2RP29;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Ankyrin repeat domain-containing protein SOWAHB;
DE AltName: Full=Ankyrin repeat domain-containing protein 56;
DE AltName: Full=Protein sosondowah homolog B;
GN Name=SOWAHB; Synonyms=ANKRD56;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106 AND SER-271, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC A6NEL2; P50402: EMD; NbExp=3; IntAct=EBI-23696033, EBI-489887;
CC -!- SIMILARITY: Belongs to the SOWAH family. {ECO:0000305}.
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DR EMBL; AC104687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137241; AAI37242.1; -; mRNA.
DR EMBL; BC137255; AAI37256.1; -; mRNA.
DR CCDS; CCDS34017.1; -.
DR RefSeq; NP_001025041.1; NM_001029870.1.
DR AlphaFoldDB; A6NEL2; -.
DR SMR; A6NEL2; -.
DR BioGRID; 131341; 39.
DR IntAct; A6NEL2; 1.
DR STRING; 9606.ENSP00000334879; -.
DR GlyGen; A6NEL2; 3 sites, 1 O-linked glycan (3 sites).
DR iPTMnet; A6NEL2; -.
DR PhosphoSitePlus; A6NEL2; -.
DR BioMuta; SOWAHB; -.
DR EPD; A6NEL2; -.
DR jPOST; A6NEL2; -.
DR MassIVE; A6NEL2; -.
DR PaxDb; A6NEL2; -.
DR PeptideAtlas; A6NEL2; -.
DR PRIDE; A6NEL2; -.
DR ProteomicsDB; 989; -.
DR Antibodypedia; 50696; 78 antibodies from 16 providers.
DR DNASU; 345079; -.
DR Ensembl; ENST00000334306.4; ENSP00000334879.2; ENSG00000186212.4.
DR GeneID; 345079; -.
DR KEGG; hsa:345079; -.
DR MANE-Select; ENST00000334306.4; ENSP00000334879.2; NM_001029870.3; NP_001025041.1.
DR UCSC; uc003hki.4; human.
DR CTD; 345079; -.
DR DisGeNET; 345079; -.
DR GeneCards; SOWAHB; -.
DR HGNC; HGNC:32958; SOWAHB.
DR HPA; ENSG00000186212; Tissue enhanced (liver).
DR neXtProt; NX_A6NEL2; -.
DR OpenTargets; ENSG00000186212; -.
DR PharmGKB; PA145149864; -.
DR VEuPathDB; HostDB:ENSG00000186212; -.
DR eggNOG; ENOG502QRSJ; Eukaryota.
DR GeneTree; ENSGT00950000183003; -.
DR HOGENOM; CLU_020213_0_0_1; -.
DR InParanoid; A6NEL2; -.
DR OMA; WECLQNG; -.
DR OrthoDB; 1531345at2759; -.
DR PhylomeDB; A6NEL2; -.
DR TreeFam; TF331362; -.
DR PathwayCommons; A6NEL2; -.
DR SignaLink; A6NEL2; -.
DR BioGRID-ORCS; 345079; 14 hits in 1070 CRISPR screens.
DR GenomeRNAi; 345079; -.
DR Pharos; A6NEL2; Tdark.
DR PRO; PR:A6NEL2; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; A6NEL2; protein.
DR Bgee; ENSG00000186212; Expressed in mucosa of transverse colon and 83 other tissues.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..793
FT /note="Ankyrin repeat domain-containing protein SOWAHB"
FT /id="PRO_0000317240"
FT REPEAT 630..659
FT /note="ANK 1"
FT REPEAT 669..699
FT /note="ANK 2"
FT REGION 83..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..523
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 106
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 271
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 761
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BZW2"
FT VARIANT 152
FT /note="D -> G (in dbSNP:rs2703129)"
FT /id="VAR_059126"
FT VARIANT 377
FT /note="P -> T (in dbSNP:rs2703130)"
FT /id="VAR_048280"
SQ SEQUENCE 793 AA; 85742 MW; 8072B1D09C52F32F CRC64;
MARELSQEAL LDFLCQAGGR VTNAALLSHF KSFLRDPDAS PSQHQHRREL FKGFVNSVAA
VRQDPDGTKY VVLKRRYRDL LGEEGLQRPR EPPAAAPSAG GAAPCSPRGA RRGEPPQQQP
RRRRREKEPE EEPAGAAARA ADAACNGLPG SDSRRAPGKG GGSKGSPGQR PPVPAAAAAG
AQARASCAAA KTQGRCCWEC LQNNLAVLPG ELGALPHSAT AEEKPARALP AQDDRGASRE
REEGALAEPA PVPAVAHSPP ATVEAATSRA SPPALLPGPA PRGDRPELLT PSSLHYSTLQ
QQQQRTREWV ARHPQVPEAR DQGPIRAWSV LPDNFLQLPL EPGSTEPNSE PPDPCLSSHS
LFPVVPDESW ESWAGNPSLT VFRSIRCQLS LQDLDDFVDQ ESDGSEESSS GPKDSPGASE
EGLQVVLGTP DRGKLRNPAG GLSVSRKEGS PSRSPQGLRN RGDGHISQQV PAGANGLAGH
PLKPLPWPVP KLRRSLRRSS LAGRAKLSSS DEEYLDEGLL KRSRRPPRSR KPSKAGTAPS
PRVDAGLSLK LAEVKAVVAE RGWRHSLWVP SGEGSAALAP HRTSEHKSSL VPLDAREHEW
IVKLASGSWI QVWTLFWEDP QLALHKDFLT GYTALHWIAK HGDLRALQDL VSGAKKAGIV
LDVNVRSSCG YTPLHLAAIH GHQGVIKLLV QRLASRVNVR DSSGKKPWQY LTSNTSGEIW
QLLGAPRGKP IFPVYPLVGS SSPTRKAKSK EISRSVTRKT SFAALLKSQH NKWKLANQYE
KFHSPREREE YSD
