SWAHB_MOUSE
ID SWAHB_MOUSE Reviewed; 760 AA.
AC Q8BZW2; Q8BZS7;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Ankyrin repeat domain-containing protein SOWAHB;
DE AltName: Full=Ankyrin repeat domain-containing protein 56;
DE AltName: Full=Protein sosondowah homolog B;
GN Name=Sowahb; Synonyms=Ankrd56;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cecum, Cerebellum, and Colon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132 AND SER-728, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the SOWAH family. {ECO:0000305}.
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DR EMBL; AK033423; BAC28281.1; -; mRNA.
DR EMBL; AK033641; BAC28403.1; -; mRNA.
DR EMBL; AK137429; BAE23349.1; -; mRNA.
DR CCDS; CCDS19435.1; -.
DR RefSeq; NP_780479.1; NM_175270.4.
DR AlphaFoldDB; Q8BZW2; -.
DR SMR; Q8BZW2; -.
DR STRING; 10090.ENSMUSP00000055267; -.
DR iPTMnet; Q8BZW2; -.
DR PhosphoSitePlus; Q8BZW2; -.
DR MaxQB; Q8BZW2; -.
DR PaxDb; Q8BZW2; -.
DR PRIDE; Q8BZW2; -.
DR ProteomicsDB; 254699; -.
DR Antibodypedia; 50696; 78 antibodies from 16 providers.
DR DNASU; 78088; -.
DR Ensembl; ENSMUST00000061328; ENSMUSP00000055267; ENSMUSG00000045314.
DR GeneID; 78088; -.
DR KEGG; mmu:78088; -.
DR UCSC; uc008ydw.1; mouse.
DR CTD; 345079; -.
DR MGI; MGI:1925338; Sowahb.
DR VEuPathDB; HostDB:ENSMUSG00000045314; -.
DR eggNOG; ENOG502QRSJ; Eukaryota.
DR GeneTree; ENSGT00950000183003; -.
DR HOGENOM; CLU_020213_0_0_1; -.
DR InParanoid; Q8BZW2; -.
DR OMA; WECLQNG; -.
DR OrthoDB; 1531345at2759; -.
DR PhylomeDB; Q8BZW2; -.
DR TreeFam; TF331362; -.
DR BioGRID-ORCS; 78088; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q8BZW2; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8BZW2; protein.
DR Bgee; ENSMUSG00000045314; Expressed in epithelium of small intestine and 139 other tissues.
DR Genevisible; Q8BZW2; MM.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..760
FT /note="Ankyrin repeat domain-containing protein SOWAHB"
FT /id="PRO_0000317241"
FT REPEAT 597..626
FT /note="ANK 1"
FT REPEAT 636..666
FT /note="ANK 2"
FT REGION 82..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 132
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 239
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A6NEL2"
FT MOD_RES 728
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 760 AA; 83542 MW; 9E4386D1FD33679E CRC64;
MAGELSQEAL LDFLCQAGGR VRNAELLSHF KSFLRDPHVS PGQLQERRER FKGFVNSVAA
VRQDPDGTKY VVLKRRYRDL LGEEGLQRPG PVDGKPRGHR RRDPEPQKPP AGAGTQVDVG
GSAQKVAGPD PSPEDSPNQR TPEPEAAQAR GRCAAVGTRG RCCWECQQNG WGQSTGQPLP
EDLGDPAVAC EKPERAAPAR DDLGAPGWLR EGEAAEHAPG SVPPVWPPTA VEAAGSPTSP
PALPPHPAPS REPLELFTAG SPNHSTQQLQ QQHQRTQEWV ARYLQVPEPE IQAPTRAWSV
LPDNFLQLPS ETAFGVSETS SALPEPALSF HSLLPVVLDE SSESWPGNAP STVFRSIRCQ
LSLQDLNDFV EQESHGSEES SSGPKESPGT PEEGLQPVLR TSSWGELRDP VEDLFLPPND
SPCLIRRDLG YRGNAPSFRK VPTVAKSLGD HPQEPFPALK FRRSVRRSSR TGRTKSPSSS
DEEHPDEDLW KRSRRPPRSR KPSKAGALPS PRVDAVLVQK LADANAVASQ PHSSWIPSRD
GSAALIPHRP SEHRSPLVPL DTREHEWIVR LASGSWLHVL TLFWEDPQLA LHRDFLTGYT
ALHWIAKHGD LCALQDLVSG AQKAGIALDV NVRSSCGYTP LHLAAIHGHQ GVIKLLVQRL
ASRVNIRDCS GKKPWQYLNS NVSGETWQLL GAPRGKPIFP VYSLVQSSSP ARKVKSREVS
RNVTRKTSLA ALLKTQHNKW KLASQYEKIH TSKEREEYSD
