SWAHC_MOUSE
ID SWAHC_MOUSE Reviewed; 512 AA.
AC Q8C0J6; Q8BWN1;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Ankyrin repeat domain-containing protein SOWAHC;
DE AltName: Full=Ankyrin repeat domain-containing protein 57;
DE AltName: Full=Protein sosondowah homolog C;
GN Name=Sowahc; Synonyms=Ankrd57;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Lung, Pancreas, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-395, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- SIMILARITY: Belongs to the SOWAH family. {ECO:0000305}.
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DR EMBL; AK030944; BAC27191.1; -; mRNA.
DR EMBL; AK050497; BAC34291.1; -; mRNA.
DR CCDS; CCDS59544.1; -.
DR RefSeq; NP_766527.3; NM_172939.3.
DR AlphaFoldDB; Q8C0J6; -.
DR SMR; Q8C0J6; -.
DR BioGRID; 234481; 1.
DR IntAct; Q8C0J6; 1.
DR STRING; 10090.ENSMUSP00000138351; -.
DR iPTMnet; Q8C0J6; -.
DR PhosphoSitePlus; Q8C0J6; -.
DR EPD; Q8C0J6; -.
DR jPOST; Q8C0J6; -.
DR MaxQB; Q8C0J6; -.
DR PeptideAtlas; Q8C0J6; -.
DR PRIDE; Q8C0J6; -.
DR ProteomicsDB; 254700; -.
DR Antibodypedia; 33168; 105 antibodies from 19 providers.
DR DNASU; 268301; -.
DR Ensembl; ENSMUST00000182161; ENSMUSP00000138351; ENSMUSG00000098188.
DR GeneID; 268301; -.
DR KEGG; mmu:268301; -.
DR UCSC; uc011xed.1; mouse.
DR CTD; 65124; -.
DR MGI; MGI:3606051; Sowahc.
DR VEuPathDB; HostDB:ENSMUSG00000098188; -.
DR eggNOG; ENOG502QVDE; Eukaryota.
DR GeneTree; ENSGT00950000183003; -.
DR HOGENOM; CLU_041239_2_0_1; -.
DR InParanoid; Q8C0J6; -.
DR OMA; HHSAEGW; -.
DR OrthoDB; 1531345at2759; -.
DR PhylomeDB; Q8C0J6; -.
DR Reactome; R-MMU-8980692; RHOA GTPase cycle.
DR Reactome; R-MMU-9013026; RHOB GTPase cycle.
DR Reactome; R-MMU-9035034; RHOF GTPase cycle.
DR BioGRID-ORCS; 268301; 1 hit in 68 CRISPR screens.
DR ChiTaRS; Sowahc; mouse.
DR PRO; PR:Q8C0J6; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8C0J6; protein.
DR Bgee; ENSMUSG00000098188; Expressed in urinary bladder urothelium and 221 other tissues.
DR Genevisible; Q8C0J6; MM.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Methylation; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..512
FT /note="Ankyrin repeat domain-containing protein SOWAHC"
FT /id="PRO_0000274341"
FT REPEAT 288..317
FT /note="ANK 1"
FT REPEAT 327..357
FT /note="ANK 2"
FT REGION 126..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 82
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 125
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q53LP3"
FT MOD_RES 205
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q53LP3"
FT MOD_RES 395
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT CONFLICT 55..60
FT /note="NAVATV -> MPWPPL (in Ref. 1; BAC34291)"
FT /evidence="ECO:0000305"
FT CONFLICT 119
FT /note="E -> Q (in Ref. 1; BAC34291)"
FT /evidence="ECO:0000305"
FT CONFLICT 123
FT /note="Q -> K (in Ref. 1; BAC34291)"
FT /evidence="ECO:0000305"
FT CONFLICT 167
FT /note="S -> T (in Ref. 1; BAC34291)"
FT /evidence="ECO:0000305"
FT CONFLICT 330
FT /note="T -> S (in Ref. 1; BAC27191)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 512 AA; 54938 MW; AA4B1D706B1607F8 CRC64;
MEGSLELSSE AILRFLAERG GRAGHSELVQ HFRDVLGGQR EQRTRARERF KELVNAVATV
RTDPADGTKY VHLKKRFCTG DSPPLEAKLP REPPRIEVTE EPQVPDLAAE PCEGSQLQEA
NPQLSLGLGG EVSDQEPPAP AQGGAQGKDS PPQEVEAVSW ASGPGSSENL KLPPQGEAEG
GSSPSGPNTP RSARQNFRDL VLGSSPQLKR SVGPGDGNAG GRSRGGGDSD TASLASSSAE
EESSVGASVT LDPLDHAWML SASEGKWDSL EGLLTCEPGL LSKRDFITGF TCLHWAAKHG
RQELLAMLVN FATKHQLPVN INAKSSGGYT ALHLAAMHGH VEVVKLLVGA YDADVDIRDY
SGRKASQYLS ESIAEEIKNL VGALDEDDGD SPAARGGGRW RLSKVLPSHI THKLSPVVED
GAELHHHVPE GWTGGSKAKD SGRKASGSSS GRMKPRLNKI RFRTQIIHTT PSFRDAKPTL
EEGEEEEEEE EERSLRGYSS SFKLRPKSNV FG
