SWAHD_HUMAN
ID SWAHD_HUMAN Reviewed; 315 AA.
AC A6NJG2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Ankyrin repeat domain-containing protein SOWAHD;
DE AltName: Full=Ankyrin repeat domain-containing protein 58;
DE AltName: Full=Protein sosondowah homolog D;
GN Name=SOWAHD; Synonyms=ANKRD58;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
CC -!- SIMILARITY: Belongs to the SOWAH family. {ECO:0000305}.
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DR EMBL; CR593492; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC005052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS43984.1; -.
DR RefSeq; NP_001099046.1; NM_001105576.2.
DR AlphaFoldDB; A6NJG2; -.
DR SMR; A6NJG2; -.
DR IntAct; A6NJG2; 1.
DR MINT; A6NJG2; -.
DR STRING; 9606.ENSP00000340975; -.
DR iPTMnet; A6NJG2; -.
DR PhosphoSitePlus; A6NJG2; -.
DR BioMuta; SOWAHD; -.
DR EPD; A6NJG2; -.
DR MassIVE; A6NJG2; -.
DR MaxQB; A6NJG2; -.
DR PaxDb; A6NJG2; -.
DR PeptideAtlas; A6NJG2; -.
DR PRIDE; A6NJG2; -.
DR ProteomicsDB; 1333; -.
DR Antibodypedia; 56549; 74 antibodies from 15 providers.
DR DNASU; 347454; -.
DR Ensembl; ENST00000343905.5; ENSP00000340975.3; ENSG00000187808.5.
DR GeneID; 347454; -.
DR KEGG; hsa:347454; -.
DR MANE-Select; ENST00000343905.5; ENSP00000340975.3; NM_001105576.3; NP_001099046.1.
DR UCSC; uc010nql.4; human.
DR CTD; 347454; -.
DR GeneCards; SOWAHD; -.
DR HGNC; HGNC:32960; SOWAHD.
DR HPA; ENSG00000187808; Tissue enhanced (intestine, lymphoid tissue, testis).
DR neXtProt; NX_A6NJG2; -.
DR OpenTargets; ENSG00000187808; -.
DR PharmGKB; PA145149865; -.
DR VEuPathDB; HostDB:ENSG00000187808; -.
DR eggNOG; ENOG502QPPI; Eukaryota.
DR GeneTree; ENSGT00950000183003; -.
DR HOGENOM; CLU_083908_0_0_1; -.
DR InParanoid; A6NJG2; -.
DR OMA; HMFPFFQ; -.
DR OrthoDB; 1531345at2759; -.
DR PhylomeDB; A6NJG2; -.
DR TreeFam; TF331362; -.
DR PathwayCommons; A6NJG2; -.
DR SignaLink; A6NJG2; -.
DR BioGRID-ORCS; 347454; 4 hits in 692 CRISPR screens.
DR GenomeRNAi; 347454; -.
DR Pharos; A6NJG2; Tdark.
DR PRO; PR:A6NJG2; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; A6NJG2; protein.
DR Bgee; ENSG00000187808; Expressed in granulocyte and 81 other tissues.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..315
FT /note="Ankyrin repeat domain-containing protein SOWAHD"
FT /id="PRO_0000315705"
FT REPEAT 112..141
FT /note="ANK 1"
FT REPEAT 147..162
FT /note="ANK 2"
FT REPEAT 186..216
FT /note="ANK 3"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 254
FT /note="T -> A (in dbSNP:rs12841259)"
FT /id="VAR_061019"
SQ SEQUENCE 315 AA; 33803 MW; 8123EC387A0883D8 CRC64;
MAQLGGAANR APTASLAPTS QSLRCAPQPR PSRADTGSLG RYWGKAAAAA SREHPFPGTL
MHSAAGSGRR RGALRELLGL QRAAPAGWLS EERAEELGGP SGPGSSRLCL EPREHAWILA
AAEGRYEVLR ELLEAEPELL LRGDPITGYS VLHWLAKHGR HEELILVHDF ALRRGLRLDV
SAPGSGGLTP LHLAALQGHD MVIKVLVGAL GADATRRDHS GHRACHYLRP DAPWRLRELS
GAEEWEMESG SGCTNLNNNS SGTTAWRAAS AVGATAVETS RRVAASRTKA KDTAGSRVAQ
MHSLFRHLFP SFQDR
