SWAP_CAEEL
ID SWAP_CAEEL Reviewed; 749 AA.
AC Q10580; Q17484; Q8WQH0;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein SWAP;
DE AltName: Full=Suppressor of white apricot protein homolog;
GN Name=swp-1; Synonyms=swap; ORFNames=B0336.9;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM A).
RX PubMed=7971282; DOI=10.1093/nar/22.21.4510;
RA Spikes D.A., Kramer J., Bingham P.M., van Doren K.;
RT "SWAP pre-mRNA splicing regulators are a novel, ancient protein family
RT sharing a highly conserved sequence motif with the prp21 family of
RT constitutive splicing proteins.";
RL Nucleic Acids Res. 22:4510-4519(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: It is a regulator of pre-mRNA splicing (and, possibly, of
CC other RNA processing events). It may regulate its own expression at the
CC level of RNA processing.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q10580-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q10580-2; Sequence=VSP_004438, VSP_004439;
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DR EMBL; U06932; AAA64937.1; -; mRNA.
DR EMBL; U06933; AAA64938.1; -; Genomic_DNA.
DR EMBL; FO080138; CCD61525.1; -; Genomic_DNA.
DR EMBL; FO080138; CCD61526.1; -; Genomic_DNA.
DR PIR; S53765; S50095.
DR RefSeq; NP_001021120.1; NM_001025949.4.
DR RefSeq; NP_741149.1; NM_171132.3. [Q10580-1]
DR AlphaFoldDB; Q10580; -.
DR SMR; Q10580; -.
DR BioGRID; 41022; 3.
DR DIP; DIP-26070N; -.
DR IntAct; Q10580; 1.
DR MINT; Q10580; -.
DR STRING; 6239.B0336.9d; -.
DR EPD; Q10580; -.
DR PaxDb; Q10580; -.
DR PeptideAtlas; Q10580; -.
DR EnsemblMetazoa; B0336.9a.1; B0336.9a.1; WBGene00006359. [Q10580-1]
DR EnsemblMetazoa; B0336.9b.1; B0336.9b.1; WBGene00006359. [Q10580-2]
DR EnsemblMetazoa; B0336.9b.2; B0336.9b.2; WBGene00006359. [Q10580-2]
DR EnsemblMetazoa; B0336.9b.3; B0336.9b.3; WBGene00006359. [Q10580-2]
DR EnsemblMetazoa; B0336.9b.4; B0336.9b.4; WBGene00006359. [Q10580-2]
DR EnsemblMetazoa; B0336.9b.5; B0336.9b.5; WBGene00006359. [Q10580-2]
DR EnsemblMetazoa; B0336.9b.6; B0336.9b.6; WBGene00006359. [Q10580-2]
DR GeneID; 175795; -.
DR UCSC; B0336.9b.1; c. elegans. [Q10580-1]
DR CTD; 175795; -.
DR WormBase; B0336.9a; CE31143; WBGene00006359; swp-1. [Q10580-1]
DR WormBase; B0336.9b; CE30068; WBGene00006359; swp-1. [Q10580-2]
DR eggNOG; KOG1847; Eukaryota.
DR InParanoid; Q10580; -.
DR PRO; PR:Q10580; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00006359; Expressed in germ line (C elegans) and 4 other tissues.
DR ExpressionAtlas; Q10580; baseline and differential.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000395; P:mRNA 5'-splice site recognition; IBA:GO_Central.
DR Gene3D; 1.10.10.790; -; 2.
DR InterPro; IPR000061; Surp.
DR InterPro; IPR040397; SWAP.
DR InterPro; IPR035967; SWAP/Surp_sf.
DR InterPro; IPR019147; SWAP_N_domain.
DR PANTHER; PTHR13161; PTHR13161; 1.
DR Pfam; PF09750; DRY_EERY; 1.
DR Pfam; PF01805; Surp; 2.
DR SMART; SM01141; DRY_EERY; 1.
DR SMART; SM00648; SWAP; 2.
DR SUPFAM; SSF109905; SSF109905; 2.
DR PROSITE; PS50128; SURP; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; mRNA processing; mRNA splicing; Reference proteome;
KW Repeat; RNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..749
FT /note="Protein SWAP"
FT /id="PRO_0000072341"
FT REPEAT 166..209
FT /note="SURP motif 1"
FT REPEAT 391..431
FT /note="SURP motif 2"
FT REGION 8..124
FT /note="Dry CEEERYL"
FT REGION 105..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..656
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..692
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..749
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..84
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_004438"
FT VAR_SEQ 514..515
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_004439"
SQ SEQUENCE 749 AA; 86310 MW; 7F2627E37CD1C590 CRC64;
MPCNCFKSNV HVQEYKDLLV FGYASTIFPN DYQSEHIAEE RHTVPCLGDP ENRVDRYDCR
LLLPSIDVAI KRNGSPSEQC PTEAMEEDMC EEERYLDMYK DIQREQEKEE EEKRRNDQRN
AIGFDYGTGK VKARESDSED EPFEPPEGIK FPVGLELPSN MKLHHIIEKT ASFIVANGTQ
MEIVIKAKQR NNAEQFGFLE FDHRLNPFYK YLQKLIREKK YIPDLNKRPK KLTKTSRAST
SKPAISSSLA AIAAAHGSDS EDSDSDYELH PSLLSGGAKR PVTPEKPGAI GPRKKPVEPE
KPPDFTLKPV GDISQRNDVY AALFKNLAHV TRQAAGVEEV KMNVEEAKKE KENDHLDDPE
YREWYENFYG RPCPWIGPRP MIPATPDLEP ILNSYAEHVA QRGLEAEASL AAREDLQLHF
MEPKSPYYSY YHHKVRMHQW RMYQPIEQNL SPLVLNSPAP PSAVSSPGPS SLMSLNLSTP
EPPLNRRQRR RLLDSSRLDE SITEPGVIDP ITMLQIPKSV STPANLDILK TPISFSLRND
EPRDESSFRF DPDLDETAGP SDTTANFSDI SGLFPPPTPP VIPPSTQMQV DRKEKARIFM
EKLLQEKKAK KLQEEEERSK LEEETRKKAE KISESLSERK NTGRSDRREE APKGARSLDE
IINNRINSLL SESGFEPVEE MKRTDEDRER KRHRKRSRSR RRSRSCSPRD RSREHKKSRK
SGRHHRSRSR SSSRDRHRRN RSRSRDRRR
