SWA_DROME
ID SWA_DROME Reviewed; 548 AA.
AC P40688; Q9W400;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Protein swallow;
GN Name=swa; ORFNames=CG3429;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=Canton-S;
RX PubMed=1806330; DOI=10.1002/dvg.1020120502;
RA Chao Y.-C., Donahue K.M., Pokrywka N.J., Stephenson E.C.;
RT "Sequence of swallow, a gene required for the localization of bicoid
RT message in Drosophila eggs.";
RL Dev. Genet. 12:333-341(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=7507030; DOI=10.1242/dev.119.2.457;
RA Hegde J., Stephenson E.C.;
RT "Distribution of swallow protein in egg chambers and embryos of Drosophila
RT melanogaster.";
RL Development 119:457-470(1993).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362; SER-368; SER-463;
RP SER-471; SER-475; SER-483; SER-485 AND SER-487, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Has a role in localizing bicoid mRNA at the anterior margin
CC of the oocyte during oogenesis, and a poorly characterized role in
CC nuclear divisions in early embryogenesis. {ECO:0000269|PubMed:1806330}.
CC -!- SUBUNIT: May be a homo- or heterodimer. {ECO:0000269|PubMed:1806330}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1806330,
CC ECO:0000269|PubMed:7507030}. Note=Uniformly distributed in eggs,
CC becomes localized to the nuclei during early mitotic divisions in early
CC embryogenesis. Enters each nucleus at the beginning of mitosis,
CC occupies a position complementary to that of condensed chromatin, and
CC leaves each nucleus at the end of mitosis.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC {ECO:0000269|PubMed:1806330}.
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DR EMBL; X56023; CAA39500.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF46160.3; -; Genomic_DNA.
DR EMBL; AY069487; AAL39632.1; -; mRNA.
DR PIR; S20806; S20806.
DR RefSeq; NP_511060.2; NM_078505.4.
DR PDB; 3BRL; X-ray; 1.90 A; C=287-296.
DR PDB; 3E2B; X-ray; 2.00 A; C=281-296.
DR PDB; 6XOR; NMR; -; A/B=205-275.
DR PDBsum; 3BRL; -.
DR PDBsum; 3E2B; -.
DR PDBsum; 6XOR; -.
DR AlphaFoldDB; P40688; -.
DR BMRB; P40688; -.
DR SMR; P40688; -.
DR BioGRID; 58067; 6.
DR DIP; DIP-17669N; -.
DR ELM; P40688; -.
DR IntAct; P40688; 6.
DR STRING; 7227.FBpp0070884; -.
DR iPTMnet; P40688; -.
DR PaxDb; P40688; -.
DR ABCD; P40688; 13 sequenced antibodies.
DR DNASU; 31580; -.
DR EnsemblMetazoa; FBtr0070922; FBpp0070884; FBgn0003655.
DR GeneID; 31580; -.
DR KEGG; dme:Dmel_CG3429; -.
DR UCSC; CG3429-RA; d. melanogaster.
DR CTD; 31580; -.
DR FlyBase; FBgn0003655; swa.
DR VEuPathDB; VectorBase:FBgn0003655; -.
DR eggNOG; ENOG502TB8W; Eukaryota.
DR HOGENOM; CLU_042201_0_0_1; -.
DR InParanoid; P40688; -.
DR OMA; ELSDCQQ; -.
DR OrthoDB; 945992at2759; -.
DR PhylomeDB; P40688; -.
DR SignaLink; P40688; -.
DR BioGRID-ORCS; 31580; 0 hits in 1 CRISPR screen.
DR EvolutionaryTrace; P40688; -.
DR GenomeRNAi; 31580; -.
DR PRO; PR:P40688; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0003655; Expressed in ovary and 8 other tissues.
DR ExpressionAtlas; P40688; baseline and differential.
DR Genevisible; P40688; DM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0070840; F:dynein complex binding; TAS:FlyBase.
DR GO; GO:0003729; F:mRNA binding; ISS:FlyBase.
DR GO; GO:0007015; P:actin filament organization; IMP:FlyBase.
DR GO; GO:0008595; P:anterior/posterior axis specification, embryo; IGI:FlyBase.
DR GO; GO:0045450; P:bicoid mRNA localization; TAS:FlyBase.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0019094; P:pole plasm mRNA localization; IMP:FlyBase.
DR GO; GO:0007317; P:regulation of pole plasm oskar mRNA localization; IGI:FlyBase.
PE 1: Evidence at protein level;
KW 3D-structure; Cell cycle; Cell division; Developmental protein; Mitosis;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..548
FT /note="Protein swallow"
FT /id="PRO_0000072342"
FT REGION 67..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 362
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 368
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 463
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 471
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 475
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 483
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 485
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 487
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT HELIX 207..269
FT /evidence="ECO:0007829|PDB:6XOR"
FT STRAND 288..294
FT /evidence="ECO:0007829|PDB:3BRL"
SQ SEQUENCE 548 AA; 62070 MW; B8E0351C7B005159 CRC64;
MSLQDESFPT DELFDQLNNL SSSGARNTWF AEHHKPAVFE RDTAPFLEIC YADPDFDADG
DVANKSAKTC VSDPVGRDQE DEDDYDEDVD GDDHKLGCEK APLGSGRSSK AVSYQDIHSA
YTKRRFQHVT SKVGQYIAEI QAQDQKRRNV KFAGFQRVNS MPESLTPTLQ QVYVHDGDFK
VDKNCQTHSN SDSNYNSNSN NSSSSFDRLL AENESLQQKI NSLRVEAKRL QGFNEYVQER
LDRKTDDFVK MKCNFETLRT ELSECQQKLR RQQDNSQHHF MYHIRSATSA KATQTDFLVD
TIPASGNVLV TPHPLGDLTY NSSKGSIELA LLSVAPSARV AQNPVQVQRA IHPQSLDFSS
VSTEADGSGS GEHRVETSSR ALVRRTPAPN NSETSQPSSN DSAIEVEAHE EERPSSRRQW
EQQGELISPR QWGQHEGMYY FDKRNNRVIE VMGFNISQGR NQSHDTIHNQ SINDSQTRLL
VHSMSMSHLE AHDHFRSKRT TLGSRMLRFL GPCVRCRNGD PLNRSNVTYK DGLPAMPEEE
FVDQRNQR
