ID   SWA_DROPS               Reviewed;         537 AA.
AC   Q9U9I5; Q29JJ4;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 3.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Protein swallow;
GN   Name=swa; ORFNames=GA17446;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11180817; DOI=10.1007/s004270050023;
RA   Huang Z., Pokrywka N.J., Yoder J.H., Stephenson E.C.;
RT   "Analysis of a swallow homologue from Drosophila pseudoobscura.";
RL   Dev. Genes Evol. 210:157-161(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Has a role in localizing bicoid mRNA at the anterior margin
CC       of the oocyte during oogenesis, and a poorly characterized role in
CC       nuclear divisions in early embryogenesis. {ECO:0000250}.
CC   -!- SUBUNIT: May be constituted of a homo- or heterodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Uniformly distributed in eggs,
CC       becomes localized to the nuclei during early mitotic divisions in early
CC       embryogenesis. Swallow enters each nucleus at the beginning of mitosis,
CC       occupies a position complementary to that of condensed chromatin, and
CC       leaves each nucleus at the end of mitosis (By similarity).
CC       {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD49350.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AF169634; AAD49350.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CH379063; EAL32307.2; -; Genomic_DNA.
DR   RefSeq; XP_001355250.2; XM_001355214.3.
DR   AlphaFoldDB; Q9U9I5; -.
DR   SMR; Q9U9I5; -.
DR   ELM; Q9U9I5; -.
DR   STRING; 7237.FBpp0273185; -.
DR   EnsemblMetazoa; FBtr0274747; FBpp0273185; FBgn0027807.
DR   GeneID; 4815687; -.
DR   KEGG; dpo:Dpse_GA17446; -.
DR   eggNOG; ENOG502TB8W; Eukaryota.
DR   HOGENOM; CLU_042201_0_0_1; -.
DR   InParanoid; Q9U9I5; -.
DR   OMA; ELSDCQQ; -.
DR   Proteomes; UP000001819; Chromosome X.
DR   Bgee; FBgn0027807; Expressed in female reproductive system and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Developmental protein; Mitosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..537
FT                   /note="Protein swallow"
FT                   /id="PRO_0000072343"
FT   REGION          344..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        356..406
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        350
FT                   /note="P -> L (in Ref. 1; AAD49350)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        390..391
FT                   /note="RG -> A (in Ref. 1; AAD49350)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   537 AA;  59641 MW;  BC0715A31691CCE7 CRC64;
     MSLEDESFPA DELFEQLNSA SIGASRQFKS QFGEHDQPEA FERNPAPFLT SDCSDESSFI
     DAANKSAKTC VSDPVGLDQC EEEEEVDKDF EDSALANGNS ELQIKSARSS KSVSYQDIHS
     AHTKRRYKHV TSKVAKYIAD IHAQDQQRRN ATKKFQRHSS MPEYLTPTAR ERGAHFSVDE
     LHNLDESLDN SSAGNITDAK TPNDSYERLL SENERLQNDK EDLKSYSDYL QTKLDEKAME
     NMQLRRNFDV LRTDLTDCKE KLKRNQSYSL RSLNFCPPAS VPKATQTDHE LLSHAPNISR
     LSNMVAIADS GTPLPGSNTN NLTYDSSAGS IEVALLSVAP AARQPNAGKP KKNIQPHSLD
     FSNDSTEAEP NGNGTTSTGH SSSRAITSRR GAAPNNSESS HPSSNDSAIE VEALDLRSPY
     HRQPQGSIYP PMQDWGHSDG IYFFDKRNSR VIEVRSINVS QSSNPEQNSG TSETNLLNQS
     HVQFRHKRTS MGTRMLRLLG PCVRCTDTNQ SVNASSATYT IGLPLLREEY GGRHTDR