SWC2_ARATH
ID SWC2_ARATH Reviewed; 365 AA.
AC F4IP06; Q0WT50; Q9ZQA0;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=SWR1 complex subunit 2;
GN Name=SWC2; OrderedLocusNames=At2g36740; ORFNames=F13K3.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, AND INTERACTION WITH SWC6 AND H2A.F/Z PROTEINS.
RX PubMed=17470967; DOI=10.1242/dev.001891;
RA Choi K., Park C., Lee J., Oh M., Noh B., Lee I.;
RT "Arabidopsis homologs of components of the SWR1 complex regulate flowering
RT and plant development.";
RL Development 134:1931-1941(2007).
CC -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC dependent exchange of histone H2A for the H2A variant H2A.F/Z leading
CC to transcriptional regulation of selected genes (e.g. FLC) by chromatin
CC remodeling. {ECO:0000269|PubMed:17470967}.
CC -!- SUBUNIT: Component of the SWR1 chromatin-remodeling complex composed of
CC at least ARP6/ESD1/SUF3, PIE1, SWC6, SWC2 and H2AZs (HTA8, HTA9,
CC HTA11). Interacts directly with SWC6 and H2AZs, but not with ARP6.
CC {ECO:0000269|PubMed:17470967}.
CC -!- INTERACTION:
CC F4IP06; Q1PF16: BHLH19; NbExp=3; IntAct=EBI-1537394, EBI-2367867;
CC F4IP06; O23628: H2AV; NbExp=3; IntAct=EBI-1537394, EBI-1537433;
CC F4IP06; Q9FHW2: SWC6; NbExp=3; IntAct=EBI-1537394, EBI-1537353;
CC -!- SIMILARITY: Belongs to the VPS72/YL1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD20150.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC006282; AAD20150.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC09293.1; -; Genomic_DNA.
DR EMBL; AK227712; BAE99698.1; -; mRNA.
DR PIR; B84784; B84784.
DR RefSeq; NP_181212.2; NM_129229.4.
DR AlphaFoldDB; F4IP06; -.
DR BioGRID; 3590; 18.
DR IntAct; F4IP06; 21.
DR STRING; 3702.AT2G36740.1; -.
DR PaxDb; F4IP06; -.
DR PRIDE; F4IP06; -.
DR ProteomicsDB; 226550; -.
DR EnsemblPlants; AT2G36740.1; AT2G36740.1; AT2G36740.
DR GeneID; 818246; -.
DR Gramene; AT2G36740.1; AT2G36740.1; AT2G36740.
DR KEGG; ath:AT2G36740; -.
DR Araport; AT2G36740; -.
DR TAIR; locus:2040580; AT2G36740.
DR eggNOG; KOG2897; Eukaryota.
DR HOGENOM; CLU_040862_1_0_1; -.
DR InParanoid; F4IP06; -.
DR OrthoDB; 1468037at2759; -.
DR PRO; PR:F4IP06; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IP06; baseline and differential.
DR Genevisible; F4IP06; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000812; C:Swr1 complex; IDA:TAIR.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0043486; P:histone exchange; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR008895; Vps72/YL1.
DR InterPro; IPR013272; Vps72/YL1_C.
DR PANTHER; PTHR13275; PTHR13275; 1.
DR Pfam; PF05764; YL1; 1.
DR Pfam; PF08265; YL1_C; 1.
DR SMART; SM00993; YL1_C; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Developmental protein; Differentiation; Flowering;
KW Reference proteome.
FT CHAIN 1..365
FT /note="SWR1 complex subunit 2"
FT /id="PRO_0000423731"
FT REGION 43..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 123..150
FT /evidence="ECO:0000255"
FT COILED 184..225
FT /evidence="ECO:0000255"
FT COMPBIAS 47..74
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 189
FT /note="M -> V (in Ref. 3; BAE99698)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 365 AA; 42148 MW; 15A76C12BBDDBA53 CRC64;
MEIDEEEPMV FLDRTTRATR GKRMTKLLDD EVEEDEQFWN QEALKEEEHD DEYEAEREVA
DEFDSDFNDD EPEPDAVAVN EKELRDLPKK RLIYPGKTAS KKKKKKTKVV SQLEYIPGDE
KPGEELGNKE QEEKEENEAQ EDMEGEKVIR KSTRTSVVVR QAERDALRAA IQATTKPIQR
KKVGEEKRMT QEEMLLEAAQ TEIMNLRNLE RVLAREEEVK KKAIVHKAVY KGPQIRYHSK
DGCNYLEFCN GASFNSELST KSVPYPEKAV CVITGLPAKY RDPKTGLPYA TRDAFKAIRE
RFMDEHDGLR KKMEMGDLFD TLVAKGFATK QKRTKIPKSN KSFSLRSSAR FLSSESEEES
EEDSD
