ID   SWC3_ASHGO              Reviewed;         688 AA.
AC   Q758T8;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=SWR1-complex protein 3;
GN   Name=SWC3; OrderedLocusNames=AEL336W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 446-463.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Involved in chromosome stability (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin remodeling complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWC3 family. {ECO:0000305}.
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DR   EMBL; AE016818; AAS52348.2; -; Genomic_DNA.
DR   RefSeq; NP_984524.2; NM_209877.2.
DR   AlphaFoldDB; Q758T8; -.
DR   STRING; 33169.AAS52348; -.
DR   PRIDE; Q758T8; -.
DR   EnsemblFungi; AAS52348; AAS52348; AGOS_AEL336W.
DR   GeneID; 4620694; -.
DR   KEGG; ago:AGOS_AEL336W; -.
DR   eggNOG; ENOG502QWM7; Eukaryota.
DR   HOGENOM; CLU_008595_1_0_1; -.
DR   InParanoid; Q758T8; -.
DR   OMA; NLWYQLD; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0000812; C:Swr1 complex; IBA:GO_Central.
DR   GO; GO:0007029; P:endoplasmic reticulum organization; IEA:EnsemblFungi.
DR   GO; GO:0043486; P:histone exchange; IBA:GO_Central.
DR   InterPro; IPR037651; Swc3.
DR   PANTHER; PTHR28108; PTHR28108; 2.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Coiled coil; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..688
FT                   /note="SWR1-complex protein 3"
FT                   /id="PRO_0000076332"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          174..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          317..469
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          483..504
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          168..225
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..241
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..444
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        451..468
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        484..504
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   688 AA;  78780 MW;  F225B9D19E964B16 CRC64;
     MARLRSRTAT TEKDATESSK VPVPRRRRGQ HEDTEEPDTY GLEDDEKSSG RPFRILEKLP
     CSAEPPRYDV LTHALSVRDS AVLYNSLLAS RRTWIKAEMF ELYWSKQYMN MKERERMLKE
     GIDPDDIDQS AAREKMHKLC DGILTGGPHT LPVRLFILKN DEIEQKWQFM QESRKKEKEV
     RRKREAEEKE RRREERKRLQ QLKKERKLKE VEHTKKEKIE RKRENDTERD QLRKGRKDNK
     GPSVLSRMGT TIKSKGLTTF SKAQQQEIDN QKMIANLNLL AQRDPALNKL MIAVANGQAP
     PADVERFKVF IERARNMEPP PNWKPRLSSR PVIKRTEEPT VEQQESASQT PSTPLPRKAS
     PESSQVDNLS SPPHGSDPNS SFTEASMSDS RGELSETKSG GSLVPDSTGS SGQALDKGPT
     DASGSANDLS RPGATLSSTD GAPPLKQETI PVRDMGDKNA DKPLEAHGAI SEKGTTITIK
     AEEGTAPRQK RKYTKRKKEV EDEDKSMQLT TFQQKYLNGA DILFEYLENS NMRFLFPKDA
     ILEQLENEES YLMSWIVVHN KKEIEQFKLK VLKGLNKNKP NEEETEVQPC LFNVYEHPNC
     PEVLYTPMTV TLSNIPKKFT PIILNSVNPA ESVRAYMSTI LARGRRLNGF NLWYQLDAYD
     DKDLAESLRC ELKEYEQGFK SKRQKKQL