ID   SWC3_CANGA              Reviewed;         659 AA.
AC   Q6FRS1;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=SWR1-complex protein 3;
GN   Name=SWC3; OrderedLocusNames=CAGL0H06391g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Involved in chromosome stability (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin remodeling complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWC3 family. {ECO:0000305}.
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DR   EMBL; CR380954; CAG60006.1; -; Genomic_DNA.
DR   RefSeq; XP_447073.1; XM_447073.1.
DR   AlphaFoldDB; Q6FRS1; -.
DR   STRING; 5478.XP_447073.1; -.
DR   EnsemblFungi; CAG60006; CAG60006; CAGL0H06391g.
DR   GeneID; 2888819; -.
DR   KEGG; cgr:CAGL0H06391g; -.
DR   CGD; CAL0131456; CAGL0H06391g.
DR   VEuPathDB; FungiDB:CAGL0H06391g; -.
DR   eggNOG; ENOG502QWM7; Eukaryota.
DR   HOGENOM; CLU_008595_1_0_1; -.
DR   InParanoid; Q6FRS1; -.
DR   OMA; NLWYQLD; -.
DR   Proteomes; UP000002428; Chromosome H.
DR   GO; GO:0000812; C:Swr1 complex; IEA:EnsemblFungi.
DR   GO; GO:0007029; P:endoplasmic reticulum organization; IEA:EnsemblFungi.
DR   GO; GO:0043486; P:histone exchange; IEA:EnsemblFungi.
DR   InterPro; IPR037651; Swc3.
DR   PANTHER; PTHR28108; PTHR28108; 2.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Coiled coil; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..659
FT                   /note="SWR1-complex protein 3"
FT                   /id="PRO_0000076333"
FT   REGION          28..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          191..286
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        41..62
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..298
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        361..380
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..470
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   659 AA;  76311 MW;  08D429E6ED64D9A1 CRC64;
     MAVALRARNA VKVEDGIDTS NIIEEVDDNT KGTRSRASRR RRRRGDEEEK HSEEETYNEF
     NDDGTLKTEG TLQTGNGSGR PFELVAGLPC SLDVPQYNSA LTFPLSVRDS GVLYSSLLSS
     RRTWISGEMF EVYWTRANKV PSLAIKDESI IKELESSKEQ DASGKDRMQR MCDCELMAGP
     HTFSIKLFIV KDDEKEKKWQ EEQEYKKKEK EEQKKLESEQ RKKRAEEKKQ MLQLKKQERE
     KQMQLQKEAR ARAKKEQAEA RQRQKEEERQ RKLMNKERVK EQKASTSKPK KDQNKKNSDQ
     HMIANLNIMA QRDPELKKLM AKVANGQANM QEIEEFKRVI ELAKNLPPPG TPPAKPEVQK
     AQSKPTDSNE TSADSSKSEI LQESKTNESD KKATAEQATE PKTHSEENKP ESENQSRDNS
     EKSASSHNQE ASIKKEADAN SVIKKESSDG DGNKSQQPKR KYNKAPKVAD ELTEKEKEMQ
     LTAFQQKYVT GAELVLEFAE NTNFRFLLPK KAIIQYIPES NRYKMSWLQI HNQSDITRFY
     KRQVKELTRR IHNAEEKQRV TDEYNVFRDK KCPSPLFSSM TVTFSGIHVK FNSIMMNSFD
     PKEEVRGYME DVLAVGTRLS GYNLWYQLDG YDDRELAERL RSELNEYEQS LKPKRQKKQ