ID   SWC3_KLULA              Reviewed;         758 AA.
AC   Q6CKU6;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=SWR1-complex protein 3;
GN   Name=SWC3; OrderedLocusNames=KLLA0F08019g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Involved in chromosome stability (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin remodeling complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWC3 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98151.1; -; Genomic_DNA.
DR   RefSeq; XP_455443.1; XM_455443.1.
DR   AlphaFoldDB; Q6CKU6; -.
DR   SMR; Q6CKU6; -.
DR   STRING; 28985.XP_455443.1; -.
DR   EnsemblFungi; CAG98151; CAG98151; KLLA0_F08019g.
DR   GeneID; 2894793; -.
DR   KEGG; kla:KLLA0_F08019g; -.
DR   eggNOG; ENOG502QWM7; Eukaryota.
DR   HOGENOM; CLU_008595_1_0_1; -.
DR   InParanoid; Q6CKU6; -.
DR   OMA; NLWYQLD; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0000812; C:Swr1 complex; IEA:InterPro.
DR   GO; GO:0043486; P:histone exchange; IEA:InterPro.
DR   InterPro; IPR037651; Swc3.
DR   PANTHER; PTHR28108; PTHR28108; 3.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Coiled coil; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..758
FT                   /note="SWR1-complex protein 3"
FT                   /id="PRO_0000076334"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          153..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          323..577
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          151..233
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        7..34
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..176
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        183..200
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..231
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..434
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        435..488
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        489..505
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        522..555
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   758 AA;  87016 MW;  3E1A0D250ABB7966 CRC64;
     MSKKRGRRHT AKEDSNSDYE TDTYGLADGD DKSRPYYLVE DLPCSLEPPR YDTFTYPLSV
     KDSAVLYSSL LSSRRTWVKG EMFQLYWAKQ YMNTKEKEEL KKEGIDPDSI DQSAAREKMN
     KLCDCMMQGG PHQFPIRLFI LKNDEVERAW NEAKEAKKRD REVRKKQQEE EKRLKKERKL
     LRKKLKQEAL EKEKEKNKDK VKKPRKPYKK SAKRLEAERL KKEEKAKAAA NTSGVKKKIS
     KTSNVKKKKM KAVVRPKPYE EQVMILNLNK MARNDKQLND LMIKVAGGQA SLAEITQFKK
     YIEKAKAMPP PSGTWKPMLE EVEVTDDGES DEDVKELEVT EKSEDVTPTE VALPKAAVAA
     KEVKDVVVTP NLPPGTENSG NGKPPSLDES NAQESTDVNK NQPIQRLNIS KNVQSVKNDI
     TENTDLASNE HMNEKQVQKT PESTTEHKPD EKPKDAAMSK SNEKKPDEDT AQDTSKDDEN
     KSDKSDSDSD SDSDSDNDSS SSDESDNEDN TSQTKNSIDN TDDGVTSEKA DTNTDVSSDK
     PPDDIKSEGE VAAPRVKRKY RRRSKVKTEE EEEEEKAMQL TTFQQKYSNG ADMVFEYVEN
     ANVRFLLPKY SILEQLEGEE SYLLSFIVVH NRREVALFTT RKLKELNKKK NKEDHIKPED
     YNPFEDARCP DPLFSSITLK LTGIPKKFSN IILNSFHPQE RVQLYMKSII DRGSRLSGYN
     LWYQLDAYDD KELAERLRVG LKEYEQTFKS KRQKKQIL