SWC3_YEAST
ID SWC3_YEAST Reviewed; 625 AA.
AC P31376; D6VPK7;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=SWR1-complex protein 3;
GN Name=SWC3; Synonyms=FUN36, SWC1; OrderedLocusNames=YAL011W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204511 / S288c / AB972;
RX PubMed=8458570; DOI=10.1139/g93-005;
RA Ouellette B.F.F., Clark M.W., Keng T., Storms R.K., Zhong W.-W., Zeng B.,
RA Fortin N., Delaney S., Barton A.B., Kaback D.B., Bussey H.;
RT "Sequencing of chromosome I from Saccharomyces cerevisiae: analysis of a 32
RT kb region between the LTE1 and SPO7 genes.";
RL Genome 36:32-42(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7731988; DOI=10.1073/pnas.92.9.3809;
RA Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N.,
RA Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J.,
RA Storms R.K.;
RT "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP IDENTIFICATION IN THE SWR1 COMPLEX, FUNCTION OF THE SWR1 COMPLEX, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=14690608; DOI=10.1016/s1097-2765(03)00497-0;
RA Krogan N.J., Keogh M.-C., Datta N., Sawa C., Ryan O.W., Ding H., Haw R.A.,
RA Pootoolal J., Tong A., Canadien V., Richards D.P., Wu X., Emili A.,
RA Hughes T.R., Buratowski S., Greenblatt J.F.;
RT "A Snf2 family ATPase complex required for recruitment of the histone H2A
RT variant Htz1.";
RL Mol. Cell 12:1565-1576(2003).
RN [5]
RP IDENTIFICATION OF PROBABLE INITIATION SITE.
RX PubMed=12748633; DOI=10.1038/nature01644;
RA Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.;
RT "Sequencing and comparison of yeast species to identify genes and
RT regulatory elements.";
RL Nature 423:241-254(2003).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [8]
RP IDENTIFICATION IN THE SWR1 COMPLEX, FUNCTION OF THE SWR1 COMPLEX, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=15045029; DOI=10.1371/journal.pbio.0020131;
RA Kobor M.S., Venkatasubrahmanyam S., Meneghini M.D., Gin J.W.,
RA Jennings J.L., Link A.J., Madhani H.D., Rine J.;
RT "A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p
RT deposits histone variant H2A.Z into euchromatin.";
RL PLoS Biol. 2:587-599(2004).
RN [9]
RP IDENTIFICATION IN THE SWR1 COMPLEX, FUNCTION OF THE SWR1 COMPLEX, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=14645854; DOI=10.1126/science.1090701;
RA Mizuguchi G., Shen X., Landry J., Wu W.-H., Sen S., Wu C.;
RT "ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin
RT remodeling complex.";
RL Science 303:343-348(2004).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC transcriptional regulation of selected genes by chromatin remodeling.
CC Involved in chromosome stability. {ECO:0000269|PubMed:14645854,
CC ECO:0000269|PubMed:14690608, ECO:0000269|PubMed:15045029}.
CC -!- SUBUNIT: Component of the SWR1 chromatin remodeling complex composed of
CC at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4,
CC SWC5, SWC7 and SWR1, and perhaps BDF1. {ECO:0000269|PubMed:14645854,
CC ECO:0000269|PubMed:14690608, ECO:0000269|PubMed:15045029}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 1380 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the SWC3 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC04946.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; L05146; AAC04946.1; ALT_INIT; Genomic_DNA.
DR EMBL; BK006935; DAA06977.1; -; Genomic_DNA.
DR PIR; S36723; S36723.
DR RefSeq; NP_009391.2; NM_001178156.1.
DR AlphaFoldDB; P31376; -.
DR BioGRID; 31755; 589.
DR ComplexPortal; CPX-2122; Swr1 chromatin remodelling complex.
DR DIP; DIP-2986N; -.
DR IntAct; P31376; 21.
DR MINT; P31376; -.
DR STRING; 4932.YAL011W; -.
DR iPTMnet; P31376; -.
DR MaxQB; P31376; -.
DR PaxDb; P31376; -.
DR PRIDE; P31376; -.
DR EnsemblFungi; YAL011W_mRNA; YAL011W; YAL011W.
DR GeneID; 851222; -.
DR KEGG; sce:YAL011W; -.
DR SGD; S000000009; SWC3.
DR VEuPathDB; FungiDB:YAL011W; -.
DR eggNOG; ENOG502QWM7; Eukaryota.
DR HOGENOM; CLU_008595_1_0_1; -.
DR InParanoid; P31376; -.
DR OMA; NLWYQLD; -.
DR BioCyc; YEAST:G3O-28824-MON; -.
DR PRO; PR:P31376; -.
DR Proteomes; UP000002311; Chromosome I.
DR RNAct; P31376; protein.
DR GO; GO:0000785; C:chromatin; IDA:ComplexPortal.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0000812; C:Swr1 complex; IDA:SGD.
DR GO; GO:0006338; P:chromatin remodeling; IDA:SGD.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IMP:SGD.
DR GO; GO:0043486; P:histone exchange; IPI:SGD.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IC:ComplexPortal.
DR InterPro; IPR037651; Swc3.
DR PANTHER; PTHR28108; PTHR28108; 1.
PE 1: Evidence at protein level;
KW Activator; Chromatin regulator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..625
FT /note="SWR1-complex protein 3"
FT /id="PRO_0000072344"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..53
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 625 AA; 72514 MW; A4F13DB85B657D59 CRC64;
MPAVLRTRSK ESSIEQKPAS RTRTRSRRGK RGRDDDDDDD DEESDDAYDE VGNDYDEYAS
RAKLATNRPF EIVAGLPASV ELPNYNSSLT HPQSIKNSGV LYDSLVSSRR TWVQGEMFEL
YWRRPKKIVS ESTPAATESP TSGTIPLIRD KMQKMCDCVM SGGPHTFKVR LFILKNDKIE
QKWQDEQELK KKEKELKRKN DAEAKRLRME ERKRQQMQKK IAKEQKLQLQ KENKAKQKLE
QEALKLKRKE EMKKLKEQNK NKQGSPSSSM HDPRMIMNLN LMAQEDPKLN TLMETVAKGL
ANNSQLEEFK KFIEIAKKRS LEENPVNKRP SVTTTRPAPP SKAKDVAEDH RLNSITLVKS
SKTAATEPEP KKADDENAEK QQSKEAKTTA ESTQVDVKKE EEDVKEKGVK SEDTQKKEDN
QVVPKRKRRK NAIKEDKDMQ LTAFQQKYVQ GAEIILEYLE FTHSRYYLPK KSVVEFLEDT
DEIIISWIVI HNSKEIEKFK TKKIKAKLKA DQKLNKEDAK PGSDVEKEVS FNPLFEADCP
TPLYTPMTMK LSGIHKRFNQ IIRNSVSPME EVVKEMEKIL QIGTRLSGYN LWYQLDGYDD
EALSESLRFE LNEWEHAMRS RRHKR
