SWC4_ARATH
ID SWC4_ARATH Reviewed; 441 AA.
AC Q8VZL6; O22895;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 149.
DE RecName: Full=SWR1-complex protein 4;
GN Name=SWC4; OrderedLocusNames=At2g47210 {ECO:0000312|Araport:AT2G47210};
GN ORFNames=T8I13.5 {ECO:0000312|EMBL:AAB63821.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAL36380.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION IN THE NUA4 COMPLEX AND IN THE SWR1 COMPLEX, INTERACTION
RP WITH EAF1A; EAF1B; TAF14 AND TAF14B, AND SUBCELLULAR LOCATION.
RX DOI=10.1186/s12870-015-0461-1;
RA Bieluszewski T., Galganski L., Sura W., Bieluszewska A., Abram M.,
RA Ludwikow A., Ziolkowski P., Sadowski J.;
RT "AtEAF1 is a potential platform protein for Arabidopsis NuA4
RT acetyltransferase complex.";
RL BMC Plant Biol. 15:0-0(2015).
CC -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC transcriptional regulation of selected genes by chromatin remodeling.
CC Component of the NuA4 histone acetyltransferase complex which is
CC involved in transcriptional activation of selected genes principally by
CC acetylation of nucleosomal histone H4 and H2A. {ECO:0000305|Ref.5}.
CC -!- SUBUNIT: Component of the SWR1 chromatin-remodeling complex and of the
CC NuA4 histone acetyltransferase complex. Interacts with EAF1A, EAF1B,
CC TAF14 and TAF14B. {ECO:0000269|Ref.5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|Ref.5}.
CC -!- SIMILARITY: Belongs to the SWC4 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB63821.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002337; AAB63821.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC10814.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM61763.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM61764.1; -; Genomic_DNA.
DR EMBL; AY064024; AAL36380.1; -; mRNA.
DR EMBL; AY096610; AAM20260.1; -; mRNA.
DR EMBL; AB493595; BAH30433.1; -; mRNA.
DR PIR; D84912; D84912.
DR RefSeq; NP_001323962.1; NM_001337253.1.
DR RefSeq; NP_001323963.1; NM_001337252.1.
DR RefSeq; NP_850470.1; NM_180139.4.
DR AlphaFoldDB; Q8VZL6; -.
DR SMR; Q8VZL6; -.
DR IntAct; Q8VZL6; 4.
DR STRING; 3702.AT2G47210.1; -.
DR iPTMnet; Q8VZL6; -.
DR PaxDb; Q8VZL6; -.
DR PRIDE; Q8VZL6; -.
DR ProteomicsDB; 226551; -.
DR EnsemblPlants; AT2G47210.1; AT2G47210.1; AT2G47210.
DR EnsemblPlants; AT2G47210.2; AT2G47210.2; AT2G47210.
DR EnsemblPlants; AT2G47210.3; AT2G47210.3; AT2G47210.
DR GeneID; 819334; -.
DR Gramene; AT2G47210.1; AT2G47210.1; AT2G47210.
DR Gramene; AT2G47210.2; AT2G47210.2; AT2G47210.
DR Gramene; AT2G47210.3; AT2G47210.3; AT2G47210.
DR KEGG; ath:AT2G47210; -.
DR Araport; AT2G47210; -.
DR TAIR; locus:2065150; AT2G47210.
DR eggNOG; KOG2656; Eukaryota.
DR HOGENOM; CLU_018539_0_0_1; -.
DR InParanoid; Q8VZL6; -.
DR OMA; EKISWQW; -.
DR OrthoDB; 918816at2759; -.
DR PhylomeDB; Q8VZL6; -.
DR PRO; PR:Q8VZL6; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8VZL6; baseline and differential.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0000812; C:Swr1 complex; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IDA:TAIR.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0043486; P:histone exchange; IBA:GO_Central.
DR GO; GO:0043968; P:histone H2A acetylation; IBA:GO_Central.
DR GO; GO:0043967; P:histone H4 acetylation; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR032563; DAMP1_SANT-like.
DR InterPro; IPR008468; DMAP1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR027109; Swc4/Dmap1.
DR PANTHER; PTHR12855; PTHR12855; 1.
DR Pfam; PF05499; DMAP1; 1.
DR Pfam; PF16282; SANT_DAMP1_like; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
PE 1: Evidence at protein level;
KW Activator; Chromatin regulator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..441
FT /note="SWR1-complex protein 4"
FT /id="PRO_0000432988"
FT DOMAIN 126..175
FT /note="SANT"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 441 AA; 49824 MW; 6D98F3B4DED25A74 CRC64;
MGGTDAKDIL GLPKTPLSLT QEKKSRPQKE SHRKPDGISR EVYALTGGVA PLMPSIDLKR
RPPADEKVAW KWLSFTNSAR KDDLQLYHWV RVVNDVPPTG DYSFAKYNKS VDILKYTDEE
YENHLTDSVW TKEETDQLFE FCQNFDLRFV VIADRFPVSR TVEELKDRYY SVNRALLRAR
AQSPADVANH PLMKEPYDIT RDRERKRALS MVLSQSRHQE KKDAEILAEA KRITEMRLAA
RRAEEPDVSA NENAGLDKAD GVVPGRSVSP TSNSQLPATA VAPSTLTMAD YASTLASLRM
LHVYLRTYGL EQMVQAASSA VGLRTIKRVE QTLQDLGVNL KPKVPTKTVC DEHLELRKEI
LTLLNLQKQL QYKESEGSSH REGSYAAMPD TPKDRVFAPD PFSFGAERPI KKEQKRKGPG
RQADTPSPAH KRPRKLKASD L
