ID   SWC4_ASHGO              Reviewed;         488 AA.
AC   Q752S6;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=SWR1-complex protein 4;
GN   Name=SWC4; OrderedLocusNames=AFR497C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Component of the NuA4 histone acetyltransferase complex which is
CC       involved in transcriptional activation of selected genes principally by
CC       acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also
CC       involved in DNA repair (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin-remodeling complex and of the
CC       NuA4 histone acetyltransferase complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWC4 family. {ECO:0000305}.
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DR   EMBL; AE016819; AAS53868.1; -; Genomic_DNA.
DR   RefSeq; NP_986044.1; NM_212180.1.
DR   AlphaFoldDB; Q752S6; -.
DR   SMR; Q752S6; -.
DR   STRING; 33169.AAS53868; -.
DR   EnsemblFungi; AAS53868; AAS53868; AGOS_AFR497C.
DR   GeneID; 4622323; -.
DR   KEGG; ago:AGOS_AFR497C; -.
DR   eggNOG; KOG2656; Eukaryota.
DR   HOGENOM; CLU_018539_4_0_1; -.
DR   InParanoid; Q752S6; -.
DR   OMA; MYQSSQG; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0000812; C:Swr1 complex; IBA:GO_Central.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0043486; P:histone exchange; IBA:GO_Central.
DR   GO; GO:0043968; P:histone H2A acetylation; IBA:GO_Central.
DR   GO; GO:0043967; P:histone H4 acetylation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR032563; DAMP1_SANT-like.
DR   InterPro; IPR027109; Swc4/Dmap1.
DR   PANTHER; PTHR12855; PTHR12855; 1.
DR   Pfam; PF16282; SANT_DAMP1_like; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; DNA damage; DNA repair; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..488
FT                   /note="SWR1-complex protein 4"
FT                   /id="PRO_0000076335"
FT   DOMAIN          137..190
FT                   /note="SANT"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          290..387
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..327
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..360
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  56132 MW;  0A1EACE37A904EA1 CRC64;
     MSSSDIFDVL NIQPKSSSPH PQTSQSNAGA SKTPKPQVTG MQRELYNLLG DNTPPIVIQP
     TSKFKDRLAS LTKPSPWTHT EFEATPYVKL SHWVKGSKEL LEGQSPKSSF AKYDQKLTLP
     EFTEGEYQEF MAQAAKGANS DAPTWSYEEV QYLFDLCRRY DLRWHIVYDR YMYDESRTME
     DIREMFYTVC QKYFQAKDPG NPLLPSLAYS KDQEIQRKKY LTRLLSRSAA EIAEEEALIM
     ESRKFEMAAK KTLQEREAML RLLDHPQGDA NVSQFLTSQG MNQLYNNLLN DKQRRRKPDS
     APPENPWMKQ QQQFAQQKQQ LQLQHQQHHQ LRDQKRIEVK TDPVTPGSPK QDSPSPGRKA
     SDQSAAPRMN KKQKLEMQTA MRRKQDSEYA QHLLKNFSSE ERKSLGVTLH GEKLAPGVFL
     RSSKISTFKP SIQNKVVSVL QELGLPVRPA MPSAAVVQHH DELLRRIVTL LDLKRQQDKL
     EAEKAIVK