ID   SWC4_CANGA              Reviewed;         532 AA.
AC   Q6FTV1;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=SWR1-complex protein 4;
GN   Name=SWC4; OrderedLocusNames=CAGL0F08613g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Component of the NuA4 histone acetyltransferase complex which is
CC       involved in transcriptional activation of selected genes principally by
CC       acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also
CC       involved in DNA repair (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin-remodeling complex and of the
CC       NuA4 histone acetyltransferase complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWC4 family. {ECO:0000305}.
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DR   EMBL; CR380952; CAG59267.1; -; Genomic_DNA.
DR   RefSeq; XP_446343.1; XM_446343.1.
DR   AlphaFoldDB; Q6FTV1; -.
DR   SMR; Q6FTV1; -.
DR   STRING; 5478.XP_446343.1; -.
DR   EnsemblFungi; CAG59267; CAG59267; CAGL0F08613g.
DR   GeneID; 2887793; -.
DR   KEGG; cgr:CAGL0F08613g; -.
DR   CGD; CAL0131238; CAGL0F08613g.
DR   VEuPathDB; FungiDB:CAGL0F08613g; -.
DR   eggNOG; KOG2656; Eukaryota.
DR   HOGENOM; CLU_018539_4_0_1; -.
DR   InParanoid; Q6FTV1; -.
DR   OMA; MYQSSQG; -.
DR   Proteomes; UP000002428; Chromosome F.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:EnsemblFungi.
DR   GO; GO:0000812; C:Swr1 complex; IEA:EnsemblFungi.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0043486; P:histone exchange; IEA:EnsemblFungi.
DR   GO; GO:0043968; P:histone H2A acetylation; IEA:InterPro.
DR   GO; GO:0043967; P:histone H4 acetylation; IEA:InterPro.
DR   InterPro; IPR032563; DAMP1_SANT-like.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR027109; Swc4/Dmap1.
DR   PANTHER; PTHR12855; PTHR12855; 1.
DR   Pfam; PF16282; SANT_DAMP1_like; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; DNA damage; DNA repair; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..532
FT                   /note="SWR1-complex protein 4"
FT                   /id="PRO_0000076338"
FT   DOMAIN          181..235
FT                   /note="SANT"
FT   REGION          13..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          132..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          363..417
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        159..184
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..412
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   532 AA;  60570 MW;  D4D6CC61FD1E3215 CRC64;
     MSSSDIFDVL NIKQKSSSPN AASPSVPASG KSSKPQLTGM QRELYNLLGE NEAPVVVQSM
     NRFKEKLASN AKPTPWSLAN FKANEYLTLQ HWVKGSRELI GEEPQESEFK KYDVHLTIPE
     FTEDEYNSFI PTSNAEENEK QNIGEKVEAN GDSTDVNMTE EDTNDKVKES VPQDENKSTS
     DNKKNNEKWE YNEVKYLFDL CKKYDLRWFV IQDRYDYENS NRTLEDLKSK FYEVSKCYFK
     AKKPDDPMLQ SLNYSKDKET QRKKYLERLL ARSAAEIAEE EALIIESRKF EMAAKKTLAE
     RETLLRLLDS PQSDISVAQY LTSNGMSQLY NSLLADKSRK RKIDSAVPEN PWMKQQHQFA
     QQRQQMQQLQ QKKLEKHDAS ATPGPATTVT ATETSTNVTS AGSIPSGLQS PKKTKRQKLE
     LQTALKRKSE SEYAEQLLKI FNMDERKSLG VIAHGEKLSP GVFLRSAKIT TFKPAIQNKI
     ISTAQELGIP ARPVMPTFEV VTEYEALLKK IATLLDIKKQ IDKIEAGKQI TK