ID   SWC4_CRYNJ              Reviewed;         463 AA.
AC   P0CO96; Q55RL7; Q5KG22;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=SWR1-complex protein 4;
GN   Name=SWC4; OrderedLocusNames=CNE05140;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Component of the NuA4 histone acetyltransferase complex which is
CC       involved in transcriptional activation of selected genes principally by
CC       acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also
CC       involved in DNA repair (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin-remodeling complex and of the
CC       NuA4 histone acetyltransferase complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWC4 family. {ECO:0000305}.
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DR   EMBL; AE017345; AAW43735.1; -; Genomic_DNA.
DR   RefSeq; XP_571042.1; XM_571042.1.
DR   AlphaFoldDB; P0CO96; -.
DR   SMR; P0CO96; -.
DR   STRING; 5207.AAW43735; -.
DR   PaxDb; P0CO96; -.
DR   EnsemblFungi; AAW43735; AAW43735; CNE05140.
DR   GeneID; 3257530; -.
DR   KEGG; cne:CNE05140; -.
DR   VEuPathDB; FungiDB:CNE05140; -.
DR   eggNOG; KOG2656; Eukaryota.
DR   HOGENOM; CLU_018539_4_1_1; -.
DR   InParanoid; P0CO96; -.
DR   OMA; MYQSSQG; -.
DR   OrthoDB; 918816at2759; -.
DR   Proteomes; UP000002149; Chromosome 5.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0000812; C:Swr1 complex; IBA:GO_Central.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0043486; P:histone exchange; IBA:GO_Central.
DR   GO; GO:0043968; P:histone H2A acetylation; IBA:GO_Central.
DR   GO; GO:0043967; P:histone H4 acetylation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR032563; DAMP1_SANT-like.
DR   InterPro; IPR027109; Swc4/Dmap1.
DR   PANTHER; PTHR12855; PTHR12855; 1.
DR   Pfam; PF16282; SANT_DAMP1_like; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; DNA damage; DNA repair; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..463
FT                   /note="SWR1-complex protein 4"
FT                   /id="PRO_0000076339"
FT   DOMAIN          130..189
FT                   /note="SANT"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          285..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        287..301
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        326..346
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   463 AA;  52154 MW;  E8E7B6B8A17D09D0 CRC64;
     MSAQDVRSIL SLPPSTPLPT LSSSKKVPVP RKPDGITREL YALIGDNAPS LADAQASLAA
     VKYREKPALK GKKVHWEWTK FTPAARRDNP VRLGHWARIT DSDPNDSVEY FGKFNLHGPS
     VMEYSQFEYD QHLVDPNWTL QETEYLFELL KEYDLRFIVA ADRYAYVSPE GEKRKRSVED
     MKDRYYTICR RLIRTRTASD PVHQQHLIQA YAFDKAREIK RKQYASDLFH LTPAEIAEEE
     ALYVEITRMQ QNERRFRADR DELMRSVMGL DSGLVEVDQS AMENAIGVDK NKKKRKAEDE
     SAAPSPAPTP KKPAPNAGFD NSRCIYHLPT PSNANSLTSH LSQKHPPHQQ AFLRGSRLPL
     PKPTAAGRIT DLLAELGLSA NRLVMPTRQN MEVFEGLLNA AAALVEMRRQ VNRVEQELRV
     VRMQKEGLMP VTTNPSARVK GEAGVVTGGS EATVKAVTPV KEC