ID   SWC4_KLULA              Reviewed;         497 AA.
AC   Q6CSS3;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=SWR1-complex protein 4;
GN   Name=SWC4; OrderedLocusNames=KLLA0C18315g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Component of the NuA4 histone acetyltransferase complex which is
CC       involved in transcriptional activation of selected genes principally by
CC       acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also
CC       involved in DNA repair (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin-remodeling complex and of the
CC       NuA4 histone acetyltransferase complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWC4 family. {ECO:0000305}.
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DR   EMBL; CR382123; CAH01867.1; -; Genomic_DNA.
DR   RefSeq; XP_453016.1; XM_453016.1.
DR   AlphaFoldDB; Q6CSS3; -.
DR   SMR; Q6CSS3; -.
DR   STRING; 28985.XP_453016.1; -.
DR   EnsemblFungi; CAH01867; CAH01867; KLLA0_C18315g.
DR   GeneID; 2892076; -.
DR   KEGG; kla:KLLA0_C18315g; -.
DR   eggNOG; KOG2656; Eukaryota.
DR   HOGENOM; CLU_018539_4_0_1; -.
DR   InParanoid; Q6CSS3; -.
DR   OMA; MYQSSQG; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:EnsemblFungi.
DR   GO; GO:0000812; C:Swr1 complex; IEA:EnsemblFungi.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0043486; P:histone exchange; IEA:EnsemblFungi.
DR   GO; GO:0043968; P:histone H2A acetylation; IEA:InterPro.
DR   GO; GO:0043967; P:histone H4 acetylation; IEA:InterPro.
DR   InterPro; IPR032563; DAMP1_SANT-like.
DR   InterPro; IPR027109; Swc4/Dmap1.
DR   PANTHER; PTHR12855; PTHR12855; 1.
DR   Pfam; PF16282; SANT_DAMP1_like; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; DNA damage; DNA repair; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..497
FT                   /note="SWR1-complex protein 4"
FT                   /id="PRO_0000076342"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          286..317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          344..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        299..317
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..372
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   497 AA;  57908 MW;  90D48675A1F4C16B CRC64;
     MSSSDIFDVL NIRPKSSSPD AEAQTPTPSS GTVKHNKPQV TGIQRELYSL LGDNTPTVPI
     KQGNKFKDSL NSNIKPSPWS FVEFEANSHL KLRHWVKGSK ELVGATVEPS SFAKFNQHLT
     IPSFDEQEFQ QFMNGNNSEW KYGEVQYLFD LCRNYDMKWF VIADRFNYNG TERKLDDLKE
     MFYTVCQWYF LYKDPDNPLI SQLNFPKEKE LERKKYLERL LKRTAAEIAE EEALIIESRK
     FEMAAKKTLQ EREALLQLLD HPHSDKPISQ FLTSQGMSQL YANLLNDKNR KRKPDSNTPE
     NPWMKQQQQF AQQRQQIQHQ QQFKQGQIIQ QQQQQQQQQQ QQQQQKQQKQ QKPQSDQITS
     KDQQPSENIE VKTEGQRLNK KQKIELQNAL RRKQDSEYAE HLLEKFTLEE RKALGVIAHG
     EKLAPGVYLR SSKISTYKPA VQNKIVATLQ ELGLPVRPAM PSLEVVQEHE KLLKKIATLL
     ELKKQVDKLT AEKQIVK