ID   SWC4_NEUCR              Reviewed;         733 AA.
AC   Q870Q1; Q1K621;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=SWR1-complex protein 4;
DE   AltName: Full=Chromatin-remodeling complex protein 1;
GN   Name=crc-1; Synonyms=swc4; ORFNames=49D12.020, NCU04002;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant H2A.Z leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Component of the NuA4 histone acetyltransferase complex which is
CC       involved in transcriptional activation of selected genes principally by
CC       acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also
CC       involved in DNA repair (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin-remodeling complex and of the
CC       NuA4 histone acetyltransferase complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWC4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAD79677.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; BX295540; CAD79677.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CM002241; EAA28381.2; -; Genomic_DNA.
DR   RefSeq; XP_957617.2; XM_952524.3.
DR   AlphaFoldDB; Q870Q1; -.
DR   SMR; Q870Q1; -.
DR   STRING; 5141.EFNCRP00000003699; -.
DR   EnsemblFungi; EAA28381; EAA28381; NCU04002.
DR   GeneID; 3873788; -.
DR   KEGG; ncr:NCU04002; -.
DR   VEuPathDB; FungiDB:NCU04002; -.
DR   HOGENOM; CLU_018539_3_1_1; -.
DR   InParanoid; Q870Q1; -.
DR   OMA; MYQSSQG; -.
DR   Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0000812; C:Swr1 complex; IBA:GO_Central.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0043486; P:histone exchange; IBA:GO_Central.
DR   GO; GO:0043968; P:histone H2A acetylation; IBA:GO_Central.
DR   GO; GO:0043967; P:histone H4 acetylation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR032563; DAMP1_SANT-like.
DR   InterPro; IPR027109; Swc4/Dmap1.
DR   PANTHER; PTHR12855; PTHR12855; 1.
DR   Pfam; PF16282; SANT_DAMP1_like; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Coiled coil; DNA damage; DNA repair;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..733
FT                   /note="SWR1-complex protein 4"
FT                   /id="PRO_0000076343"
FT   DOMAIN          146..217
FT                   /note="SANT"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          98..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          371..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          564..733
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          247..299
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        105..122
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        389..432
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        459..479
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        564..656
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        700..725
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   733 AA;  80394 MW;  25C92227F8B220A6 CRC64;
     MTSHDVRDVL NLPSDHAGPR PSKKARTATP RPNLKGLARE VQNLGGDNPI AIVPEVSIFK
     KRRTVSRKPA AKWELKAFTN SARGDDGALV LRHWKRKPDG TVQDGSAEGQ DSAATADNSA
     DKPEDSSFAK FNVRVSVPQY SEDQYNTNLK HPDWTKEETD YLLELAKDFD LRWPIIWDRY
     EYAPQQPEGE TPDGMAVVPA SKPRTMEDLK ARYYEVAAKM MAVQKPAQYM TRPEFELYEM
     MLHFDPKQEQ NRKRFAENTL KRSSDEAREE EALLLEIKRI MARTERFNEE RRELYNRLDY
     PASESDINSF KTSAGLQSLL QTLLNVDKSK KRKSIMAPEN GVPPAAAAAA ATAALPPAAA
     AVAAAPEVPP AASRRESLAA SSTAGANDHH EPPVREPPVR HERQESRSHH RNESRSERAD
     RHGAHGHHHR DSVSQTPATP AEAPTPVPAP APAANKKKGP QQPERRKLSE HEEQVYGVSH
     HDRLGSGPTF RYEKINKLYS HKSGQQQMRI TNLLLELDIP ARLIMPTAAV TAQFEVLWGA
     VTTLVDLRKM SDKVDAEIKL EEAKKAERER AAREAAEARG ETVEKKGGEE EGEGGGADDK
     QKDGGGAGGD DAKDKSGESA QADEQKNDQK AEDAKAQKEQ QGEGQDQQKK GEEGLVVPIK
     EGGGEKGQGD AAAAATAAEK EAESSSNQPK IKEEADENGS SSGAGASSGA RQHKRSASVL
     SNASDKSTKK QKK